Proteintech

MMAB Polyclonal Antibody

MMAB Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

MMAB Antibody (11137-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HeLa cells using 11137-1-AP (MMAB antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

MMAB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MMAB Antibody in Immunoprecipitation (IP)

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Product Details

11137-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MMAB Fusion Protein Ag1602 (1-250 aa encoded by BC011831)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAVCGLGSR LGLGSRLGLR GCFGAARLLY PRFQSRGPQG VEDGDRPQPS SKTPRIPKIY TKTGDKGFSS TFTGERRPKD DQVFEAVGTT DELSSAIGFA LELVTEKGHT FAEELQKIQC TLQDVGSALA TPCSSAREAH LKYTTFKAGP ILELEQWIDK YTSQLPPLTA FILPSGGKIS SALHFCRAVC RRAERRVVPL VQMGETDANV AKFLNRLSDY LFTLARYAAM KEGNQEKIYM KNDPSAESEG L (1-250 aa encoded by BC011831)

Target Information

This gene encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complementation group.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hepatocyte-like cells differentiated from methylmalonic aciduria cblB type induced pluripotent stem cells: A platform for the evaluation of pharmacochaperoning.

Biochimica et biophysica acta. Molecular basis of disease

Briso-Montiano Á,Vilas A,Richard E,Ruiz-Sala P,Morato E,Desviat LR,Ugarte M,Rodríguez-Pombo P,Pérez B

Thu Sep 01 00:00:00 UTC 2022

Hepatocyte-like cells differentiated from methylmalonic aciduria cblB type induced pluripotent stem cells: A platform for the evaluation of pharmacochaperoning.

Biochimica et biophysica acta. Molecular basis of disease

Briso-Montiano Á,Vilas A,Richard E,Ruiz-Sala P,Morato E,Desviat LR,Ugarte M,Rodríguez-Pombo P,Pérez B

Thu Sep 01 00:00:00 UTC 2022

New perspectives for pharmacological chaperoning treatment in methylmalonic aciduria cblB type.

Biochimica et biophysica acta. Molecular basis of disease

Brasil S,Briso-Montiano A,Gámez A,Underhaug J,Flydal MI,Desviat L,Merinero B,Ugarte M,Martinez A,Pérez B

Thu Feb 01 00:00:00 UTC 2018

Pharmacological chaperones as a potential therapeutic option in methylmalonic aciduria cblB type.

Human molecular genetics

Jorge-Finnigan A,Brasil S,Underhaug J,Ruíz-Sala P,Merinero B,Banerjee R,Desviat LR,Ugarte M,Martinez A,Pérez B

Sun Sep 15 00:00:00 UTC 2013

Pharmacological chaperones as a potential therapeutic option in methylmalonic aciduria cblB type.

Human molecular genetics

Jorge-Finnigan A,Brasil S,Underhaug J,Ruíz-Sala P,Merinero B,Banerjee R,Desviat LR,Ugarte M,Martinez A,Pérez B

Sun Sep 15 00:00:00 UTC 2013

Functional and structural analysis of five mutations identified in methylmalonic aciduria cblB type.

Human mutation

Jorge-Finnigan A,Aguado C,Sánchez-Alcudia R,Abia D,Richard E,Merinero B,Gámez A,Banerjee R,Desviat LR,Ugarte M,Pérez B

Wed Sep 01 00:00:00 UTC 2010

Functional and structural analysis of five mutations identified in methylmalonic aciduria cblB type.

Human mutation

Jorge-Finnigan A,Aguado C,Sánchez-Alcudia R,Abia D,Richard E,Merinero B,Gámez A,Banerjee R,Desviat LR,Ugarte M,Pérez B

Wed Sep 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: aquocob(I)alamin vitamin B12s adenosyltransferase; ATP:co(I)rrinoid adenosyltransferase MMAB; ATP:Cob(I)alamin Adenosyltransferase; ATP:corrinoid adenosyltransferase; cilia and flagella associated protein 23; cob(I)alamin adenosyltransferase; cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial; Corrinoid adenosyltransferase MMAB; Methylmalonic aciduria type B homolog; Methylmalonic aciduria type B protein

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Gene Aliases: 9130222L19Rik; ATR; cblB; CFAP23; cob; MMAB

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UniProt ID: (Human) Q96EY8, (Mouse) Q9D273

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Entrez Gene ID: (Human) 326625, (Mouse) 77697

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Function(s)

ATP binding cob(I)yrinic acid a,c-diamide adenosyltransferase activity nucleotide binding transferase activity

Process(es)

cobalamin metabolic process cobalamin biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MMAB Polyclonal Antibody

MMAB Antibody (11137-1-AP) in ICC/IF

Product Details

11137-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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