Proteintech

MMP13 Polyclonal Antibody

MMP13 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 11

MMP13 Antibody (18165-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Methanol) fixed MCF-7 cells using MMP13 antibody (Product # 18165-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

MMP13 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MMP13 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

18165-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 223 publications 223 publications

Immunohistochemistry (IHC)

View 107 publications 107 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 69 publications 69 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 4 publications 4 publications

Not applicable (N/A)

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Bovine, Human, Mouse, Rabbit, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MMP13 Fusion Protein Ag12653 (100-471 aa encoded by BC074808)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DVGEYNVFP RTLKWSKMNL TYRIVNYTPD MTHSEVEKAF KKAFKVWSDV TPLNFTRLHD GIADIMISFG IKEHGDFYPF DGPSGLLAHA FPPGPNYGGD AHFDDDETWT SSSKGYNLFL VAAHEFGHSL GLDHSKDPGA LMFPIYTYTG KSHFMLPDDD VQGIQSLYGP GDEDPNPKHP KTPDKCDPSL SLDAITSLRG ETMIFKDRFF WRLHPQQVDA ELFLTKSFWP ELPNRIDAAY EHPSHDLIFI FRGRKFWALN GYDILEGYPK KISELGLPKE VKKISAAVHF EDTGKTLLFS GNQVWRYDDT NHIMDKDYPR LIEEDFPGIG DKVDAVYEKN GYIYFFNGPI QFEYSIWSNR IVRVMPANSI LWC (100-471 aa encoded by BC074808)

Target Information

MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Li Y,Sun H,Liu X,Hu Z,Jiang H,Guo H,Long X

Sun Jan 01 00:00:00 UTC 2023

Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway.

International journal of molecular medicine

Sun W,Xie W,Huang D,Cui Y,Yue J,He Q,Jiang L,Xiong J,Sun W,Yi Q

Tue Nov 01 00:00:00 UTC 2022

Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway.

International journal of molecular medicine

Sun W,Xie W,Huang D,Cui Y,Yue J,He Q,Jiang L,Xiong J,Sun W,Yi Q

Tue Nov 01 00:00:00 UTC 2022

Fermentation supernatant of Staphylococcus aureus drives catabolism in chondrocytes via NF-κB signaling mediated increase of cholesterol metabolism.

Experimental cell research

Wang Q,Huang J,Li S,Zhang Y,Sun R,Ren J,Shi S,Cui L

Sat Jan 01 00:00:00 UTC 2022

The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1.

Science signaling

Tang S,Cao Y,Cai Z,Nie X,Ruan J,Zhou Z,Ruan G,Zhu Z,Han W,Ding C

Tue May 24 00:00:00 UTC 2022

The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1.

Science signaling

Tang S,Cao Y,Cai Z,Nie X,Ruan J,Zhou Z,Ruan G,Zhu Z,Han W,Ding C

Tue May 24 00:00:00 UTC 2022

The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1.

Science signaling

Tang S,Cao Y,Cai Z,Nie X,Ruan J,Zhou Z,Ruan G,Zhu Z,Han W,Ding C

Tue May 24 00:00:00 UTC 2022

The lncRNA PILA promotes NF-κB signaling in osteoarthritis by stimulating the activity of the protein arginine methyltransferase PRMT1.

Science signaling

Tang S,Cao Y,Cai Z,Nie X,Ruan J,Zhou Z,Ruan G,Zhu Z,Han W,Ding C

Tue May 24 00:00:00 UTC 2022

Silencing of Angiopoietin-Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF-κB Pathway.

Oxidative medicine and cellular longevity

Jia C,Li X,Pan J,Ma H,Wu D,Lu H,Wang W,Zhang X,Yi X

Fri Sep 09 00:00:00 UTC 2022

Silencing of Angiopoietin-Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF-κB Pathway.

Oxidative medicine and cellular longevity

Jia C,Li X,Pan J,Ma H,Wu D,Lu H,Wang W,Zhang X,Yi X

Fri Sep 09 00:00:00 UTC 2022

Silencing of Angiopoietin-Like Protein 4 (Angptl4) Decreases Inflammation, Extracellular Matrix Degradation, and Apoptosis in Osteoarthritis via the Sirtuin 1/NF-κB Pathway.

Oxidative medicine and cellular longevity

Jia C,Li X,Pan J,Ma H,Wu D,Lu H,Wang W,Zhang X,Yi X

Fri Sep 09 00:00:00 UTC 2022

Selenium-sensitive histone deacetylase 2 is required for forkhead box O3A and regulates extracellular matrix metabolism in cartilage.

Journal of bone and mineral metabolism

Zhao Y,Guo Y,Sun M,Hussion S,Zheng Y,Huang H,Huo X,Zhao Y,Zhang F,Han Y,Ning Q,Xu P,Sun J,Lu S

Tue Nov 01 00:00:00 UTC 2022

CD40/TRAF1 decreases synovial cell apoptosis in patients with rheumatoid arthritis through JNK/NF-κB pathway.

Journal of bone and mineral metabolism

Cheng T,Wu J,Xu Y,Liu C,Zhang H,Wang M

Thu Sep 01 00:00:00 UTC 2022

Gaseous signal molecule SO₂ regulates autophagy through PI3K/AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Zhao J,Wu Q,Yang T,Nie L,Liu S,Zhou J,Chen J,Jiang Z,Xiao T,Yang J,Chu C

Tue Nov 01 00:00:00 UTC 2022

T-2 toxin induces articular cartilage damage by increasing the expression of MMP-13 via the TGF-β receptor pathway.

Human & experimental toxicology

Zhang Y,Li Z,He Y,Liu Y,Mi G,Chen J

Mon Mar 14 00:00:00 UTC 2022

T-2 toxin induces articular cartilage damage by increasing the expression of MMP-13 via the TGF-β receptor pathway.

Human & experimental toxicology

Zhang Y,Li Z,He Y,Liu Y,Mi G,Chen J

Mon Mar 14 00:00:00 UTC 2022

T-2 toxin induces articular cartilage damage by increasing the expression of MMP-13 via the TGF-β receptor pathway.

Human & experimental toxicology

Zhang Y,Li Z,He Y,Liu Y,Mi G,Chen J

Mon Mar 14 00:00:00 UTC 2022

T-2 toxin induces articular cartilage damage by increasing the expression of MMP-13 via the TGF-β receptor pathway.

Human & experimental toxicology

Zhang Y,Li Z,He Y,Liu Y,Mi G,Chen J

Mon Mar 14 00:00:00 UTC 2022

Circular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-κB signaling.

Cell death & disease

Tang S,Nie X,Ruan J,Cao Y,Kang J,Ding C

Tue Aug 09 00:00:00 UTC 2022

Circular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-κB signaling.

Cell death & disease

Tang S,Nie X,Ruan J,Cao Y,Kang J,Ding C

Tue Aug 09 00:00:00 UTC 2022

Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.

Free radical biology & medicine

Wang W,Jing X,Du T,Ren J,Liu X,Chen F,Shao Y,Sun S,Yang G,Cui X

Thu Sep 01 00:00:00 UTC 2022

Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes.

Free radical biology & medicine

Wang W,Jing X,Du T,Ren J,Liu X,Chen F,Shao Y,Sun S,Yang G,Cui X

Thu Sep 01 00:00:00 UTC 2022

FABP4 secreted by M1-polarized macrophages promotes synovitis and angiogenesis to exacerbate rheumatoid arthritis.

Bone research

Guo D,Lin C,Lu Y,Guan H,Qi W,Zhang H,Shao Y,Zeng C,Zhang R,Zhang H,Bai X,Cai D

Wed Jun 22 00:00:00 UTC 2022

Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study.

Frontiers in bioengineering and biotechnology

Jing S,Wan J,Wang T,He Z,Ding Q,Sheng G,Wang S,Zhao H,Zhu Z,Wu H,Li W

Fri Dec 23 00:00:00 UTC 2022

Flavokawain A alleviates the progression of mouse osteoarthritis: An in vitro and in vivo study.

Frontiers in bioengineering and biotechnology

Jing S,Wan J,Wang T,He Z,Ding Q,Sheng G,Wang S,Zhao H,Zhu Z,Wu H,Li W

Fri Dec 23 00:00:00 UTC 2022

Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration.

Bone research

Wang D,Peng P,Dudek M,Hu X,Xu X,Shang Q,Wang D,Jia H,Wang H,Gao B,Zheng C,Mao J,Gao C,He X,Cheng P,Wang H,Zheng J,Hoyland JA,Meng QJ,Luo Z,Yang L

Fri Feb 25 00:00:00 UTC 2022

Self-amplifying loop of NF-κB and periostin initiated by PIEZO1 accelerates mechano-induced senescence of nucleus pulposus cells and intervertebral disc degeneration.

Molecular therapy : the journal of the American Society of Gene Therapy

Wu J,Chen Y,Liao Z,Liu H,Zhang S,Zhong D,Qiu X,Chen T,Su D,Ke X,Wan Y,Zhou T,Su P

Wed Oct 05 00:00:00 UTC 2022

Intra-articular injection of a novel Wnt pathway inhibitor, SM04690, upregulates Wnt16 expression and reduces disease progression in temporomandibular joint osteoarthritis.

Bone

Hua B,Qiu J,Ye X,Liu X

Sun May 01 00:00:00 UTC 2022

S100A10 regulates tumor necrosis factor alpha-induced apoptosis in chondrocytes via the reactive oxygen species/nuclear factor-kappa B pathway.

Biotechnology and applied biochemistry

Guo Y,Li R,Dang X

Thu Dec 01 00:00:00 UTC 2022

Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2.

Oxidative medicine and cellular longevity

Wang P,Zhang S,Liu W,Chen S,Lv X,Hu B,Shao Z

Mon Apr 25 00:00:00 UTC 2022

Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis.

Drug design, development and therapy

Han H,Chen M,Li Z,Zhou S,Wu Y,Wei J

Tue Aug 16 00:00:00 UTC 2022

Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis.

Drug design, development and therapy

Han H,Chen M,Li Z,Zhou S,Wu Y,Wei J

Tue Aug 16 00:00:00 UTC 2022

Corosolic Acid Protects Rat Chondrocytes Against IL-1β-Induced ECM Degradation by Activating Autophagy via PI3K/AKT/mTOR Pathway and Ameliorates Rat Osteoarthritis.

Drug design, development and therapy

Han H,Chen M,Li Z,Zhou S,Wu Y,Wei J

Tue Aug 16 00:00:00 UTC 2022

Piceatannol suppresses inflammation and promotes apoptosis in rheumatoid arthritis‑fibroblast‑like synoviocytes by inhibiting the NF‑κB and MAPK signaling pathways.

Molecular medicine reports

Gao X,Kang X,Lu H,Xue E,Chen R,Pan J,Ma J

Sun May 01 00:00:00 UTC 2022

Piceatannol suppresses inflammation and promotes apoptosis in rheumatoid arthritis‑fibroblast‑like synoviocytes by inhibiting the NF‑κB and MAPK signaling pathways.

Molecular medicine reports

Gao X,Kang X,Lu H,Xue E,Chen R,Pan J,Ma J

Sun May 01 00:00:00 UTC 2022

Piceatannol suppresses inflammation and promotes apoptosis in rheumatoid arthritis‑fibroblast‑like synoviocytes by inhibiting the NF‑κB and MAPK signaling pathways.

Molecular medicine reports

Gao X,Kang X,Lu H,Xue E,Chen R,Pan J,Ma J

Sun May 01 00:00:00 UTC 2022

Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.

Cellular signalling

Dai WY,Luo ZP

Tue Mar 01 00:00:00 UTC 2022

Paeoniflorin inhibits pyroptosis of nucleus pulposus cells in an acidic environment and alleviates the degeneration of the intervertebral disc in rats.

Cellular signalling

Dai WY,Luo ZP

Tue Mar 01 00:00:00 UTC 2022

Arctiin-reinforced antioxidant microcarrier antagonizes osteoarthritis progression.

Journal of nanobiotechnology

Liu Y,Hou M,Pan Z,Tian X,Zhao Z,Liu T,Yang H,Shi Q,Chen X,Zhang Y,He F,Zhu X

Mon Jun 27 00:00:00 UTC 2022

Arctiin-reinforced antioxidant microcarrier antagonizes osteoarthritis progression.

Journal of nanobiotechnology

Liu Y,Hou M,Pan Z,Tian X,Zhao Z,Liu T,Yang H,Shi Q,Chen X,Zhang Y,He F,Zhu X

Mon Jun 27 00:00:00 UTC 2022

Corynoline Alleviates Osteoarthritis Development via the Nrf2/NF-κB Pathway.

Oxidative medicine and cellular longevity

Li S,Shi Y,Zhang S,Li H,Ye Z,Kong J,Hong W,Tu Y,Ren J,Meftah Z,Xie C,Wang X,Zhang X

Wed Aug 10 00:00:00 UTC 2022

NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma.

Frontiers in immunology

Xiong G,Feng Y,Yi X,Zhang X,Li X,Yang L,Yi Z,Sai B,Yang Z,Zhang Q,Kuang Y,Zhu Y

Mon Oct 10 00:00:00 UTC 2022

Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy.

Journal of nanobiotechnology

Yang L,Yu C,Fan X,Zeng T,Yang W,Xia J,Wang J,Yao L,Hu C,Jin Y,Zhu Y,Chen J,Hu Z

Sat Oct 01 00:00:00 UTC 2022

Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy.

Journal of nanobiotechnology

Yang L,Yu C,Fan X,Zeng T,Yang W,Xia J,Wang J,Yao L,Hu C,Jin Y,Zhu Y,Chen J,Hu Z

Sat Oct 01 00:00:00 UTC 2022

Enhancing autophagy and energy metabolism in the meniscus can delay the occurrence of PTOA in ACLT rat.

Frontiers in cell and developmental biology

Zhu H,Liu H,Chen X,Xu X,Zhang S,Xie D

Tue Sep 20 00:00:00 UTC 2022

Enhancing autophagy and energy metabolism in the meniscus can delay the occurrence of PTOA in ACLT rat.

Frontiers in cell and developmental biology

Zhu H,Liu H,Chen X,Xu X,Zhang S,Xie D

Tue Sep 20 00:00:00 UTC 2022

ALPK1 Accelerates the Pathogenesis of Osteoarthritis by Activating NLRP3 Signaling.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Liu X,Zhao J,Jiang H,Guo H,Li Y,Li H,Feng Y,Ke J,Long X

Sat Oct 01 00:00:00 UTC 2022

Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.

Frontiers in endocrinology

Lu R,He Z,Zhang W,Wang Y,Cheng P,Lv Z,Yuan X,Guo F,You H,Chen AM,Hu W

Tue Dec 20 00:00:00 UTC 2022

Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.

Frontiers in endocrinology

Lu R,He Z,Zhang W,Wang Y,Cheng P,Lv Z,Yuan X,Guo F,You H,Chen AM,Hu W

Tue Dec 20 00:00:00 UTC 2022

Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.

Frontiers in endocrinology

Lu R,He Z,Zhang W,Wang Y,Cheng P,Lv Z,Yuan X,Guo F,You H,Chen AM,Hu W

Tue Dec 20 00:00:00 UTC 2022

Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis.

Journal of nanobiotechnology

Zhang Y,Wang X,Chen J,Qian D,Gao P,Qin T,Jiang T,Yi J,Xu T,Huang Y,Wang Q,Zhou Z,Bao T,Zhao X,Liu H,Zheng Z,Fan J,Zhao S,Li Q,Yin G

Sat Jan 29 00:00:00 UTC 2022

Shoc2 controls ERK1/2-driven neural crest development by balancing components of the extracellular matrix.

Developmental biology

Norcross RG,Abdelmoti L,Rouchka EC,Andreeva K,Tussey O,Landestoy D,Galperin E

Thu Dec 01 00:00:00 UTC 2022

Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway.

Frontiers in pharmacology

Yao M,Zhang C,Ni L,Ji X,Hong J,Chen Y,Wang J,Li C,Lin J,Lu T,Sheng Y,Sun M,Shi M,Zhou C,Cai X

Sat Jul 16 00:00:00 UTC 2022

Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway.

Frontiers in pharmacology

Yao M,Zhang C,Ni L,Ji X,Hong J,Chen Y,Wang J,Li C,Lin J,Lu T,Sheng Y,Sun M,Shi M,Zhou C,Cai X

Sat Jul 16 00:00:00 UTC 2022

Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages.

Journal of nanobiotechnology

Jin Y,Zhang Q,Qin X,Liu Z,Li Z,Zhong X,Xia L,He J,Fang B

Thu Nov 03 00:00:00 UTC 2022

Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages.

Journal of nanobiotechnology

Jin Y,Zhang Q,Qin X,Liu Z,Li Z,Zhong X,Xia L,He J,Fang B

Thu Nov 03 00:00:00 UTC 2022

Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages.

Journal of nanobiotechnology

Jin Y,Zhang Q,Qin X,Liu Z,Li Z,Zhong X,Xia L,He J,Fang B

Thu Nov 03 00:00:00 UTC 2022

Vasorin-containing small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system.

Journal of nanobiotechnology

Liao Z,Ke W,Liu H,Tong B,Wang K,Feng X,Hua W,Wang B,Song Y,Luo R,Liang H,Zhang W,Zhao K,Li S,Yang C

Mon Sep 19 00:00:00 UTC 2022

An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration.

International journal of molecular sciences

Cheng H,Guo Q,Zhao H,Liu K,Kang H,Gao F,Guo J,Yuan X,Hu S,Li F,Yang Q,Fang Z

Mon Dec 26 00:00:00 UTC 2022

An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration.

International journal of molecular sciences

Cheng H,Guo Q,Zhao H,Liu K,Kang H,Gao F,Guo J,Yuan X,Hu S,Li F,Yang Q,Fang Z

Mon Dec 26 00:00:00 UTC 2022

An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration.

International journal of molecular sciences

Cheng H,Guo Q,Zhao H,Liu K,Kang H,Gao F,Guo J,Yuan X,Hu S,Li F,Yang Q,Fang Z

Mon Dec 26 00:00:00 UTC 2022

An Injectable Hydrogel Scaffold Loaded with Dual-Drug/Sustained-Release PLGA Microspheres for the Regulation of Macrophage Polarization in the Treatment of Intervertebral Disc Degeneration.

International journal of molecular sciences

Cheng H,Guo Q,Zhao H,Liu K,Kang H,Gao F,Guo J,Yuan X,Hu S,Li F,Yang Q,Fang Z

Mon Dec 26 00:00:00 UTC 2022

Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1.

International journal of oral science

Jin Y,Liu Z,Li Z,Li H,Zhu C,Li R,Zhou T,Fang B

Thu Jul 14 00:00:00 UTC 2022

Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1.

International journal of oral science

Jin Y,Liu Z,Li Z,Li H,Zhu C,Li R,Zhou T,Fang B

Thu Jul 14 00:00:00 UTC 2022

Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1.

International journal of oral science

Jin Y,Liu Z,Li Z,Li H,Zhu C,Li R,Zhou T,Fang B

Thu Jul 14 00:00:00 UTC 2022

Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway.

International immunopharmacology

Luo P,Huang Q,Chen S,Wang Y,Dou H

Fri Jul 01 00:00:00 UTC 2022

Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway.

International immunopharmacology

Luo P,Huang Q,Chen S,Wang Y,Dou H

Fri Jul 01 00:00:00 UTC 2022

Asiaticoside ameliorates osteoarthritis progression through activation of Nrf2/HO-1 and inhibition of the NF-κB pathway.

International immunopharmacology

Luo P,Huang Q,Chen S,Wang Y,Dou H

Fri Jul 01 00:00:00 UTC 2022

Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo.

Frontiers in pharmacology

Jiang Z,Qi G,Lu W,Wang H,Li D,Chen W,Ding L,Yang X,Yuan H,Zeng Q

Sat Oct 15 00:00:00 UTC 2022

Omaveloxolone inhibits IL-1β-induced chondrocyte apoptosis through the Nrf2/ARE and NF-κB signalling pathways in vitro and attenuates osteoarthritis in vivo.

Frontiers in pharmacology

Jiang Z,Qi G,Lu W,Wang H,Li D,Chen W,Ding L,Yang X,Yuan H,Zeng Q

Sat Oct 15 00:00:00 UTC 2022

Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway.

Molecular biology reports

Wu G,Xue P,Jin H,Zhang M,Gui C,Bao G,Xu G,Jiang J,Zhang J,Cui S,Cui Z,Sun Y

Fri Jul 01 00:00:00 UTC 2022

Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway.

Molecular biology reports

Wu G,Xue P,Jin H,Zhang M,Gui C,Bao G,Xu G,Jiang J,Zhang J,Cui S,Cui Z,Sun Y

Fri Jul 01 00:00:00 UTC 2022

Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway.

Molecular biology reports

Wu G,Xue P,Jin H,Zhang M,Gui C,Bao G,Xu G,Jiang J,Zhang J,Cui S,Cui Z,Sun Y

Fri Jul 01 00:00:00 UTC 2022

Upregulation of P2Y12 inhibits chondrocyte apoptosis in lumbar osteoarthritis through the PI3K/AKT signaling pathway.

Molecular biology reports

Wu G,Xue P,Jin H,Zhang M,Gui C,Bao G,Xu G,Jiang J,Zhang J,Cui S,Cui Z,Sun Y

Fri Jul 01 00:00:00 UTC 2022

Theaflavin-3,3'-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways.

Oxidative medicine and cellular longevity

Teng Y,Jin Z,Ren W,Lu M,Hou M,Zhou Q,Wang W,Yang H,Zou J

Tue Jul 19 00:00:00 UTC 2022

Theaflavin-3,3'-Digallate Protects Cartilage from Degradation by Modulating Inflammation and Antioxidant Pathways.

Oxidative medicine and cellular longevity

Teng Y,Jin Z,Ren W,Lu M,Hou M,Zhou Q,Wang W,Yang H,Zou J

Tue Jul 19 00:00:00 UTC 2022

Nanosilicate-Reinforced Silk Fibroin Hydrogel for Endogenous Regeneration of Both Cartilage and Subchondral Bone.

Advanced healthcare materials

Sheng R,Chen J,Wang H,Luo Y,Liu J,Chen Z,Mo Q,Chi J,Ling C,Tan X,Yao Q,Zhang W

Thu Sep 01 00:00:00 UTC 2022

Oxymatrine Protects Chondrocytes against IL-1β-triggered Apoptosis in Vitro and Inhibits Osteoarthritis in Mice Model.

Evidence-based complementary and alternative medicine : eCAM

Mohetaer D,Cao L,Wang Y

Sun Oct 09 00:00:00 UTC 2022

Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages.

Journal of nanobiotechnology

Li K,Yan G,Huang H,Zheng M,Ma K,Cui X,Lu D,Zheng L,Zhu B,Cheng J,Zhao J

Thu Jan 20 00:00:00 UTC 2022

Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages.

Journal of nanobiotechnology

Li K,Yan G,Huang H,Zheng M,Ma K,Cui X,Lu D,Zheng L,Zhu B,Cheng J,Zhao J

Thu Jan 20 00:00:00 UTC 2022

Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages.

Journal of nanobiotechnology

Li K,Yan G,Huang H,Zheng M,Ma K,Cui X,Lu D,Zheng L,Zhu B,Cheng J,Zhao J

Thu Jan 20 00:00:00 UTC 2022

Anti-inflammatory and immunomodulatory effects of the extracellular vesicles derived from human umbilical cord mesenchymal stem cells on osteoarthritis via M2 macrophages.

Journal of nanobiotechnology

Li K,Yan G,Huang H,Zheng M,Ma K,Cui X,Lu D,Zheng L,Zhu B,Cheng J,Zhao J

Thu Jan 20 00:00:00 UTC 2022

Calycosin mitigates chondrocyte inflammation and apoptosis by inhibiting the PI3K/AKT and NF-κB pathways.

Journal of ethnopharmacology

Shi X,Jie L,Wu P,Zhang N,Mao J,Wang P,Yin S

Fri Oct 28 00:00:00 UTC 2022

Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Shen Y,Fan X,Qu Y,Tang M,Huang Y,Peng Y,Fu Q

Thu Sep 01 00:00:00 UTC 2022

Metformin mitigates cholesterol accumulation via the AMPK/SIRT1 pathway to protect osteoarthritis chondrocytes.

Biochemical and biophysical research communications

Xing H,Liang C,Wang C,Xu X,Hu Y,Qiu B

Sat Dec 03 00:00:00 UTC 2022

Transcriptomic analysis supports collective endometrial cell migration in the pathogenesis of adenomyosis.

Reproductive biomedicine online

Zhai J,Li S,Sen S,Vallvé-Juanico J,Irwin JC,Vo KC,Wan J,Du Y,Chen ZJ,Giudice LC

Thu Sep 01 00:00:00 UTC 2022

PCB153 suppressed autophagy via PI3K/Akt/mTOR and RICTOR/Akt/mTOR signaling by the upregulation of microRNA-155 in rat primary chondrocytes.

Toxicology and applied pharmacology

Liu Z,Huang Y,Jin X,Liu L,Gu H

Mon Aug 15 00:00:00 UTC 2022

PCB153 suppressed autophagy via PI3K/Akt/mTOR and RICTOR/Akt/mTOR signaling by the upregulation of microRNA-155 in rat primary chondrocytes.

Toxicology and applied pharmacology

Liu Z,Huang Y,Jin X,Liu L,Gu H

Mon Aug 15 00:00:00 UTC 2022

PCB153 suppressed autophagy via PI3K/Akt/mTOR and RICTOR/Akt/mTOR signaling by the upregulation of microRNA-155 in rat primary chondrocytes.

Toxicology and applied pharmacology

Liu Z,Huang Y,Jin X,Liu L,Gu H

Mon Aug 15 00:00:00 UTC 2022

Cartilage Repair Using Clematis Triterpenoid Saponin Delivery Microcarrier, Cultured in a Microgravity Bioreactor Prior to Application in Rabbit Model.

ACS biomaterials science & engineering

Tu P,Pan Y,Wu C,Yang G,Zhou X,Sun J,Wang L,Liu M,Wang Z,Liang Z,Guo Y,Ma Y

Mon Feb 14 00:00:00 UTC 2022

Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.

Biochemical pharmacology

Ni L,Lin Z,Hu S,Shi Y,Jiang Z,Zhao J,Zhou Y,Wu Y,Tian N,Sun L,Wu A,Pan Z,Zhang X,Wang X

Fri Apr 01 00:00:00 UTC 2022

Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.

Biochemical pharmacology

Ni L,Lin Z,Hu S,Shi Y,Jiang Z,Zhao J,Zhou Y,Wu Y,Tian N,Sun L,Wu A,Pan Z,Zhang X,Wang X

Fri Apr 01 00:00:00 UTC 2022

Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.

Biochemical pharmacology

Ni L,Lin Z,Hu S,Shi Y,Jiang Z,Zhao J,Zhou Y,Wu Y,Tian N,Sun L,Wu A,Pan Z,Zhang X,Wang X

Fri Apr 01 00:00:00 UTC 2022

Ellagic acid attenuates interleukin-1β-induced oxidative stress and exerts protective effects on chondrocytes through the Kelch-like ECH-associated protein 1 (Keap1)/ Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.

Bioengineered

Zhu W,Tang H,Li J,Guedes RM,Cao L,Guo C

Fri Apr 01 00:00:00 UTC 2022

Saikosaponin D Inhibited IL-1β Induced ATDC 5 Chondrocytes Apoptosis In Vitro and Delayed Articular Cartilage Degeneration in OA Model Mice In Vivo.

Frontiers in pharmacology

Wu X,Zhao K,Fang X,Lu F,Cheng P,Song X,Zhang W,Yao C,Zhu J,Chen H

Tue Apr 05 00:00:00 UTC 2022

Transforming growth factor-β receptors mediates matrix degradation and abnormal hypertrophy in T-2 toxin-induced hypertrophic chondrocytes.

Toxicon : official journal of the International Society on Toxinology

Zhang Y,Li Z,He Y,Zhang M,Feng Y,Fang Q,Ma T,Deng X,Chen J

Tue Feb 01 00:00:00 UTC 2022

TGF-β1 regulates chondrocyte proliferation and extracellular matrix synthesis via circPhf21a-Vegfa axis in osteoarthritis.

Cell communication and signaling : CCS

Lin S,Li H,Wu B,Shang J,Jiang N,Peng R,Xing B,Xu X,Lu H

Mon May 30 00:00:00 UTC 2022

TGF-β1 regulates chondrocyte proliferation and extracellular matrix synthesis via circPhf21a-Vegfa axis in osteoarthritis.

Cell communication and signaling : CCS

Lin S,Li H,Wu B,Shang J,Jiang N,Peng R,Xing B,Xu X,Lu H

Mon May 30 00:00:00 UTC 2022

Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.

Oxidative medicine and cellular longevity

Chen J,Cui Z,Wang Y,Lyu L,Feng C,Feng D,Cheng Y,Li Z,Sun S

Thu Mar 24 00:00:00 UTC 2022

Protective role of Achyranthes bidentata polysaccharides against chondrocyte extracellular matrix degeneration through lncRNA GAS5 in osteoarthritis.

Experimental and therapeutic medicine

Fu C,Qiu Z,Huang Y,Mei Y,Lin Q,Zeng J,Zhong W,Ma D

Mon Aug 01 00:00:00 UTC 2022

Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation.

Frontiers in bioengineering and biotechnology

Zhang F,Wang S,Gao M,Li B,He Z,Tang T,Zhu Z,Liu S,Zhou Z

Tue Jan 03 00:00:00 UTC 2023

Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation.

Frontiers in bioengineering and biotechnology

Zhang F,Wang S,Gao M,Li B,He Z,Tang T,Zhu Z,Liu S,Zhou Z

Tue Jan 03 00:00:00 UTC 2023

Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation.

Frontiers in bioengineering and biotechnology

Zhang F,Wang S,Gao M,Li B,He Z,Tang T,Zhu Z,Liu S,Zhou Z

Tue Jan 03 00:00:00 UTC 2023

Hyaluronic acid ameliorates intervertebral disc degeneration via promoting mitophagy activation.

Frontiers in bioengineering and biotechnology

Zhang F,Wang S,Gao M,Li B,He Z,Tang T,Zhu Z,Liu S,Zhou Z

Tue Jan 03 00:00:00 UTC 2023

Use of mesoporous polydopamine nanoparticles as a stable drug-release system alleviates inflammation in knee osteoarthritis.

APL bioengineering

Wang Y,Ge W,Ma Z,Ji G,Wang M,Zhou G,Wang X

Wed Jun 01 00:00:00 UTC 2022

Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway.

Frontiers in pharmacology

Guo Z,Lin J,Sun K,Guo J,Yao X,Wang G,Hou L,Xu J,Guo J,Guo F

Tue May 30 00:00:00 UTC 2023

Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway.

Frontiers in pharmacology

Guo Z,Lin J,Sun K,Guo J,Yao X,Wang G,Hou L,Xu J,Guo J,Guo F

Tue May 30 00:00:00 UTC 2023

Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Shi Y,Chen J,Li S,Wu Y,Yu C,Ni L,Xiao J,Shao Z,Zhu H,Wang J,Wang X,Zhang X

Fri Apr 01 00:00:00 UTC 2022

Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Shi Y,Chen J,Li S,Wu Y,Yu C,Ni L,Xiao J,Shao Z,Zhu H,Wang J,Wang X,Zhang X

Fri Apr 01 00:00:00 UTC 2022

Tangeretin suppresses osteoarthritis progression via the Nrf2/NF-κB and MAPK/NF-κB signaling pathways.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Shi Y,Chen J,Li S,Wu Y,Yu C,Ni L,Xiao J,Shao Z,Zhu H,Wang J,Wang X,Zhang X

Fri Apr 01 00:00:00 UTC 2022

Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.

International immunopharmacology

Qu Y,Shen Y,Teng L,Huang Y,Yang Y,Jian X,Fan S,Wu P,Fu Q

Sat Oct 01 00:00:00 UTC 2022

International immunopharmacology

Qu Y,Shen Y,Teng L,Huang Y,Yang Y,Jian X,Fan S,Wu P,Fu Q

Sat Oct 01 00:00:00 UTC 2022

Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells.

Archives of gerontology and geriatrics

Cabral VLF,Wang F,Peng X,Gao J,Zhou Z,Sun R,Bao J,Wu X

Tue Jul 12 00:00:00 UTC 2022

Omentin-1 promoted proliferation and ameliorated inflammation, apoptosis, and degeneration in human nucleus pulposus cells.

Archives of gerontology and geriatrics

Cabral VLF,Wang F,Peng X,Gao J,Zhou Z,Sun R,Bao J,Wu X

Tue Jul 12 00:00:00 UTC 2022

LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.

Orthopaedic surgery

Yi Y,Yang N,Yang Z,Tao X,Li Y

Tue Nov 01 00:00:00 UTC 2022

LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.

Orthopaedic surgery

Yi Y,Yang N,Yang Z,Tao X,Li Y

Tue Nov 01 00:00:00 UTC 2022

LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.

Orthopaedic surgery

Yi Y,Yang N,Yang Z,Tao X,Li Y

Tue Nov 01 00:00:00 UTC 2022

LncRNA TM1-3P Regulates Proliferation, Apoptosis and Inflammation of Fibroblasts in Osteoarthritis through miR-144-3p/ONECUT2 Axis.

Orthopaedic surgery

Yi Y,Yang N,Yang Z,Tao X,Li Y

Tue Nov 01 00:00:00 UTC 2022

3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy.

Frontiers in pharmacology

Tang H,Qin K,Wang A,Li S,Fang S,Gao W,Lu M,Huang W,Zhang H,Yin Z

Sat Sep 07 00:00:00 UTC 2024

3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy.

Frontiers in pharmacology

Tang H,Qin K,Wang A,Li S,Fang S,Gao W,Lu M,Huang W,Zhang H,Yin Z

Sat Sep 07 00:00:00 UTC 2024

3,3'-diindolylmethane inhibits LPS-induced human chondrocytes apoptosis and extracellular matrix degradation by activating PI3K-Akt-mTOR-mediated autophagy.

Frontiers in pharmacology

Tang H,Qin K,Wang A,Li S,Fang S,Gao W,Lu M,Huang W,Zhang H,Yin Z

Sat Sep 07 00:00:00 UTC 2024

dsRNA Induced IFNβ-MMP13 Axis Drives Corneal Wound Healing.

Investigative ophthalmology & visual science

Lan X,Zhang W,Zhu J,Huang H,Mo K,Guo H,Zhu L,Liu J,Li M,Wang L,Liu C,Ji J,Ouyang H

Tue Feb 01 00:00:00 UTC 2022

dsRNA Induced IFNβ-MMP13 Axis Drives Corneal Wound Healing.

Investigative ophthalmology & visual science

Lan X,Zhang W,Zhu J,Huang H,Mo K,Guo H,Zhu L,Liu J,Li M,Wang L,Liu C,Ji J,Ouyang H

Tue Feb 01 00:00:00 UTC 2022

Epigallocatechin-3-O-gallate ameliorates oxidative stress-induced chondrocyte dysfunction and exerts chondroprotective effects via the Keap1/Nrf2/ARE signaling pathway.

Chemical biology & drug design

Zhu W,Tang H,Cao L,Zhang J,Li J,Ma D,Guo C

Fri Jul 01 00:00:00 UTC 2022

Traumatic temporomandibular joint bony ankylosis in growing rats.

BMC oral health

Ma Z,Wang Y,Xue Y,Zhang W,Li D,Li Y,Li G,Zhou H,Hu X,Deng T,Hu K

Fri Dec 09 00:00:00 UTC 2022

Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development.

Nature communications

Nagata K,Hojo H,Chang SH,Okada H,Yano F,Chijimatsu R,Omata Y,Mori D,Makii Y,Kawata M,Kaneko T,Iwanaga Y,Nakamoto H,Maenohara Y,Tachibana N,Ishikura H,Higuchi J,Taniguchi Y,Ohba S,Chung UI,Tanaka S,Saito T

Wed Oct 19 00:00:00 UTC 2022

Tri-n-butyl phosphate delays tissue repair by dysregulating neutrophil function in zebrafish.

Toxicology and applied pharmacology

Wang Y,Cheng Z,Zhang H,Li S,Pan Y,Zhang W,Huang S,He X,Zou F,Yuan Z,Yan W,Huang H

Mon Aug 15 00:00:00 UTC 2022

Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway.

Molecules (Basel, Switzerland)

Ma T,Wang X,Qu W,Yang L,Jing C,Zhu B,Zhang Y,Xie W

Tue Dec 06 00:00:00 UTC 2022

Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway.

Molecules (Basel, Switzerland)

Ma T,Wang X,Qu W,Yang L,Jing C,Zhu B,Zhang Y,Xie W

Tue Dec 06 00:00:00 UTC 2022

Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway.

Frontiers in pharmacology

Shao Y,Sun L,Yang G,Wang W,Liu X,Du T,Chen F,Jing X,Cui X

Sat Oct 01 00:00:00 UTC 2022

Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis.

Nature communications

Zhang Y,Li S,Jin P,Shang T,Sun R,Lu L,Guo K,Liu J,Tong Y,Wang J,Liu S,Wang C,Kang Y,Zhu W,Wang Q,Zhang X,Yin F,Sun YE,Cui L

Wed May 04 00:00:00 UTC 2022

Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis.

Nature communications

Zhang Y,Li S,Jin P,Shang T,Sun R,Lu L,Guo K,Liu J,Tong Y,Wang J,Liu S,Wang C,Kang Y,Zhu W,Wang Q,Zhang X,Yin F,Sun YE,Cui L

Wed May 04 00:00:00 UTC 2022

Nodakenin attenuates cartilage degradation and inflammatory responses in a mice model of knee osteoarthritis by regulating mitochondrial Drp1/ROS/NLRP3 axis.

International immunopharmacology

Yi N,Mi Y,Xu X,Li N,Chen B,Yan K,Tan K,Zhang B,Wang L,Kuang G,Lu M

Thu Dec 01 00:00:00 UTC 2022

Nodakenin attenuates cartilage degradation and inflammatory responses in a mice model of knee osteoarthritis by regulating mitochondrial Drp1/ROS/NLRP3 axis.

International immunopharmacology

Yi N,Mi Y,Xu X,Li N,Chen B,Yan K,Tan K,Zhang B,Wang L,Kuang G,Lu M

Thu Dec 01 00:00:00 UTC 2022

Mettl3 inhibits the apoptosis and autophagy of chondrocytes in inflammation through mediating Bcl2 stability via Ythdf1-mediated m⁶A modification.

Bone

He Y,Wang W,Xu X,Yang B,Yu X,Wu Y,Wang J

Sat Jan 01 00:00:00 UTC 2022

Elevation of α-1,3 fucosylation promotes the binding ability of TNFR1 to TNF-α and contributes to osteoarthritic cartilage destruction and apoptosis.

Arthritis research & therapy

Yu H,Li M,Wen X,Yang J,Liang X,Li X,Bao X,Shu J,Ren X,Chen W,Li Z,Li Y

Fri Apr 29 00:00:00 UTC 2022

Natural product, bilobalide, improves joint health in rabbits with osteoarthritis by anti-matrix degradation and antioxidant activities.

Frontiers in veterinary science

Ma T,Chen H,Ruan H,Lv L,Yu Y,Jia L,Zhao J,Li X,Zang Y,Xu X,Zhang J,Gao L

Tue Nov 08 00:00:00 UTC 2022

Natural product, bilobalide, improves joint health in rabbits with osteoarthritis by anti-matrix degradation and antioxidant activities.

Frontiers in veterinary science

Ma T,Chen H,Ruan H,Lv L,Yu Y,Jia L,Zhao J,Li X,Zang Y,Xu X,Zhang J,Gao L

Tue Nov 08 00:00:00 UTC 2022

Stabilization of hypoxia-inducible factor-1α alleviates osteoarthritis via interacting with Per2 and resetting the circadian clock.

Tissue & cell

Wang C,Zhang Y,Wang Z,Yu W,Tong M,Yan Z

Thu Dec 01 00:00:00 UTC 2022

Stabilization of hypoxia-inducible factor-1α alleviates osteoarthritis via interacting with Per2 and resetting the circadian clock.

Tissue & cell

Wang C,Zhang Y,Wang Z,Yu W,Tong M,Yan Z

Thu Dec 01 00:00:00 UTC 2022

Periostin promotes nucleus pulposus cells apoptosis by activating the Wnt/β-catenin signaling pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Zhu D,Wang Z,Zhang G,Ma C,Qiu X,Wang Y,Liu M,Guo X,Chen H,Deng Q,Kang X

Fri Jul 01 00:00:00 UTC 2022

Exosomes derived from hypoxia preconditioned mesenchymal stem cells laden in a silk hydrogel promote cartilage regeneration via the miR-205-5p/PTEN/AKT pathway.

Acta biomaterialia

Shen K,Duan A,Cheng J,Yuan T,Zhou J,Song H,Chen Z,Wan B,Liu J,Zhang X,Zhang Y,Xie R,Liu F,Fan W,Zuo Q

Fri Apr 15 00:00:00 UTC 2022

Gastrocnemius Muscle Injury Is the Condition to Induce Cartilage Degeneration of the Rabbit Tibiofemoral Joint: A New Perspective.

BioMed research international

Li Y,Sun J,Hou Y,Wei J,Chai Y,Zhu X,Wang R

Tue Sep 13 00:00:00 UTC 2022

Inhibition of HMGB1 suppresses inflammation and catabolism in temporomandibular joint osteoarthritis via NF-κB signaling pathway.

European journal of histochemistry : EJH

Li YY,Feng YP,Liu L,Ke J,Long X

Tue Jun 21 00:00:00 UTC 2022

Inhibition of HMGB1 suppresses inflammation and catabolism in temporomandibular joint osteoarthritis via NF-κB signaling pathway.

European journal of histochemistry : EJH

Li YY,Feng YP,Liu L,Ke J,Long X

Tue Jun 21 00:00:00 UTC 2022

Spheroid Formation Enhances the Regenerative Capacity of Nucleus Pulposus Cells via Regulating N-CDH and ITGβ1 Interaction.

International journal of biological sciences

Wang Y,Wang H,Zhuo Y,Hu Y,Li X,Xu Y,Sun B,Liu M,Zou L,Liu L,Luo L,Zhao C,Li P,Zhou Q

Tue Jul 12 00:00:00 UTC 2022

TET enzymes regulate skeletal development through increasing chromatin accessibility of RUNX2 target genes.

Nature communications

Wang L,You X,Ruan D,Shao R,Dai HQ,Shen W,Xu GL,Liu W,Zou W

Thu Aug 11 00:00:00 UTC 2022

Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.

Experimental & molecular medicine

Wang J,Xia D,Lin Y,Xu W,Wu Y,Chen J,Chu J,Shen P,Weng S,Wang X,Shen L,Fan S,Shen S

Tue Mar 01 00:00:00 UTC 2022

Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.

Experimental & molecular medicine

Wang J,Xia D,Lin Y,Xu W,Wu Y,Chen J,Chu J,Shen P,Weng S,Wang X,Shen L,Fan S,Shen S

Tue Mar 01 00:00:00 UTC 2022

Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.

Experimental & molecular medicine

Wang J,Xia D,Lin Y,Xu W,Wu Y,Chen J,Chu J,Shen P,Weng S,Wang X,Shen L,Fan S,Shen S

Tue Mar 01 00:00:00 UTC 2022

Oxidative stress-induced circKIF18A downregulation impairs MCM7-mediated anti-senescence in intervertebral disc degeneration.

Experimental & molecular medicine

Wang J,Xia D,Lin Y,Xu W,Wu Y,Chen J,Chu J,Shen P,Weng S,Wang X,Shen L,Fan S,Shen S

Tue Mar 01 00:00:00 UTC 2022

The Protective Effect of Evodiamine in Osteoarthritis: An In Vitro and In Vivo Study in Mice Model.

Frontiers in pharmacology

Xian S,Lin Z,Zhou C,Wu X

Sat Jul 16 00:00:00 UTC 2022

SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.

Apoptosis : an international journal on programmed cell death

Wu ZL,Chen YJ,Zhang GZ,Xie QQ,Wang KP,Yang X,Liu TC,Wang ZQ,Zhao GH,Zhang HH

Tue Feb 01 00:00:00 UTC 2022

Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing.

Nature communications

Sivaraj KK,Majev PG,Jeong HW,Dharmalingam B,Zeuschner D,Schröder S,Bixel MG,Timmen M,Stange R,Adams RH

Fri Jan 28 00:00:00 UTC 2022

Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage.

Stem cell research & therapy

Zhou H,Shen X,Yan C,Xiong W,Ma Z,Tan Z,Wang J,Li Y,Liu J,Duan A,Liu F

Sat Jul 16 00:00:00 UTC 2022

Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate osteoarthritis of the knee in mice model by interacting with METTL3 to reduce m6A of NLRP3 in macrophage.

Stem cell research & therapy

Zhou H,Shen X,Yan C,Xiong W,Ma Z,Tan Z,Wang J,Li Y,Liu J,Duan A,Liu F

Sat Jul 16 00:00:00 UTC 2022

Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes.

Chemico-biological interactions

Wang X,Liu Z,Peng P,Gong Z,Huang J,Peng H

Sat Oct 01 00:00:00 UTC 2022

A plant-derived natural photosynthetic system for improving cell anabolism.

Nature

Chen P,Liu X,Gu C,Zhong P,Song N,Li M,Dai Z,Fang X,Liu Z,Zhang J,Tang R,Fan S,Lin X

Thu Dec 01 00:00:00 UTC 2022

ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling.

Journal of dental research

Liu X,Zhao J,Jiang H,Li H,Feng Y,Ke J,Long X

Tue Nov 01 00:00:00 UTC 2022

ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling.

Journal of dental research

Liu X,Zhao J,Jiang H,Li H,Feng Y,Ke J,Long X

Tue Nov 01 00:00:00 UTC 2022

Asporin regulated by miR-26b-5p mediates chondrocyte senescence and exacerbates osteoarthritis progression via TGF-β1/Smad2 pathway.

Rheumatology (Oxford, England)

Liu L,Zhao C,Zhang H,Lu Y,Luo B,Yao Z,Shao Y,Zeng H,Zeng C,Zhang R,Fang H,Pan J,Bai X,Cai D

Mon May 30 00:00:00 UTC 2022

Exosomes-derived miR-125-5p from cartilage endplate stem cells regulates autophagy and ECM metabolism in nucleus pulposus by targeting SUV38H1.

Experimental cell research

Chen D,Jiang X

Sun May 01 00:00:00 UTC 2022

Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage.

Journal of bone and mineral metabolism

Kaneko T,Horiuchi K,Chijimatsu R,Mori D,Nagata K,Omata Y,Yano F,Inui H,Moro T,Tanaka S,Saito T

Tue Mar 01 00:00:00 UTC 2022

HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3.

Experimental & molecular medicine

Hu B,Wang P,Zhang S,Liu W,Lv X,Shi D,Zhao L,Liu H,Wang B,Chen S,Shao Z

Tue Mar 01 00:00:00 UTC 2022

HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3.

Experimental & molecular medicine

Hu B,Wang P,Zhang S,Liu W,Lv X,Shi D,Zhao L,Liu H,Wang B,Chen S,Shao Z

Tue Mar 01 00:00:00 UTC 2022

XMU-MP-1 attenuates osteoarthritis via inhibiting cartilage degradation and chondrocyte apoptosis.

Frontiers in bioengineering and biotechnology

Hao X,Zhao J,Jia L,He T,Wang H,Fan J,Yang Y,Su F,Lu Q,Zheng C,Yang L,Jie Q

Fri Oct 07 00:00:00 UTC 2022

MicroRNA-497 Reduction and Increase of Its Family Member MicroRNA-424 Lead to Dysregulation of Multiple Inflammation Related Genes in Synovial Fibroblasts With Rheumatoid Arthritis.

Frontiers in immunology

Wang S,Xu J,Guo Y,Cai Y,Ren X,Zhu W,Geng M,Meng L,Jiang C,Lu S

Mon Jun 28 00:00:00 UTC 2021

BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.

Aging

Shao Y,Zhao C,Pan J,Zeng C,Zhang H,Liu L,Fan K,Liu X,Luo B,Fang H,Bai X,Zhang H,Cai D

Fri Mar 19 00:00:00 UTC 2021

1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages.

Journal of inflammation research

Duan A,Ma Z,Liu W,Shen K,Zhou H,Wang S,Kong R,Shao Y,Chen Y,Guo W,Liu F

Thu Jun 30 00:00:00 UTC 2022

1,25-Dihydroxyvitamin D Inhibits Osteoarthritis by Modulating Interaction Between Vitamin D Receptor and NLRP3 in Macrophages.

Journal of inflammation research

Duan A,Ma Z,Liu W,Shen K,Zhou H,Wang S,Kong R,Shao Y,Chen Y,Guo W,Liu F

Thu Jun 30 00:00:00 UTC 2022

Therapeutic Effects of Naringin in Rheumatoid Arthritis: Network Pharmacology and Experimental Validation.

Frontiers in pharmacology

Aihaiti Y,Song Cai Y,Tuerhong X,Ni Yang Y,Ma Y,Shi Zheng H,Xu K,Xu P

Tue Jun 01 00:00:00 UTC 2021

TGF-β1-stimulation of NFATC2 and ATF3 proteins and their interaction for matrix metalloproteinase 13 expression in human breast cancer cells.

International journal of biological macromolecules

Rohini M,Vairamani M,Selvamurugan N

Wed Dec 01 00:00:00 UTC 2021

Bardoxolone-Methyl Prevents Oxidative Stress-Mediated Apoptosis and Extracellular Matrix Degradation in vitro and Alleviates Osteoarthritis in vivo.

Drug design, development and therapy

Pang Z,Jiang Z,Zhu R,Song C,Tang H,Cao L,Guo C

Thu Jan 20 00:00:00 UTC 2022

Single-Cell Profiles of Age-Related Osteoarthritis Uncover Underlying Heterogeneity Associated With Disease Progression.

Frontiers in molecular biosciences

Liu W,Chen Y,Zeng G,Yang S,Yang T,Ma M,Song W

Fri Jan 28 00:00:00 UTC 2022

Effects of mechanical stress and deficiency of dihydrotestosterone or 17β-estradiol on Temporomandibular Joint Osteoarthritis in mice.

Osteoarthritis and cartilage

Ootake T,Ishii T,Sueishi K,Watanabe A,Ishizuka Y,Amano K,Nagao M,Nishimura K,Nishii Y

Mon Nov 01 00:00:00 UTC 2021

ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.

Biochemical and biophysical research communications

Ding W,Ge Y,Sun H,Xu J,Gu H,Bian C,Chen H,Jiang L,Yin X

Fri Apr 23 00:00:00 UTC 2021

Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.

Molecular medicine reports

Huang H,Liu K,Ou H,Qian X,Wan J

Tue Jun 01 00:00:00 UTC 2021

Senolytic agent Quercetin ameliorates intervertebral disc degeneration via the Nrf2/NF-κB axis.

Osteoarthritis and cartilage

Shao Z,Wang B,Shi Y,Xie C,Huang C,Chen B,Zhang H,Zeng G,Liang H,Wu Y,Zhou Y,Tian N,Wu A,Gao W,Wang X,Zhang X

Mon Mar 01 00:00:00 UTC 2021

Scleraxis expressing scleral cells respond to inflammatory stimulation.

Histochemistry and cell biology

Atta G,Schroedl F,Kaser-Eichberger A,Spitzer G,Traweger A,Heindl LM,Tempfer H

Sun Aug 01 00:00:00 UTC 2021

Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.

Ecotoxicology and environmental safety

Yu FF,Zuo J,Fu X,Gao MH,Sun L,Yu SY,Li Z,Zhou GY,Ba Y

Wed Dec 01 00:00:00 UTC 2021

Suramin attenuates intervertebral disc degeneration by inhibiting NF-κB signalling pathway.

Bone & joint research

Liu ZM,Lu CC,Shen PC,Chou SH,Shih CL,Chen JC,Tien YC

Sun Aug 01 00:00:00 UTC 2021

The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration.

International journal of molecular sciences

Serjeant M,Moon PM,Quinonez D,Penuela S,Beier F,Séguin CA

Fri Jan 22 00:00:00 UTC 2021

METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response.

Life sciences

Sang W,Xue S,Jiang Y,Lu H,Zhu L,Wang C,Ma J

Sun Aug 01 00:00:00 UTC 2021

Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.

Frontiers in pharmacology

Lu R,Yu X,Liang S,Cheng P,Wang Z,He ZY,Lv ZT,Wan J,Mo H,Zhu WT,Chen AM

Tue Dec 21 00:00:00 UTC 2021

Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.

Frontiers in pharmacology

Lu R,Yu X,Liang S,Cheng P,Wang Z,He ZY,Lv ZT,Wan J,Mo H,Zhu WT,Chen AM

Tue Dec 21 00:00:00 UTC 2021

Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect.

Frontiers in pharmacology

Lu R,Yu X,Liang S,Cheng P,Wang Z,He ZY,Lv ZT,Wan J,Mo H,Zhu WT,Chen AM

Tue Dec 21 00:00:00 UTC 2021

Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.

Food & function

Xie C,Ma H,Shi Y,Li J,Wu H,Wang B,Shao Z,Huang C,Chen J,Sun L,Zhou Y,Tian N,Wu Y,Gao W,Wu A,Wang X,Zhang X

Sun Mar 21 00:00:00 UTC 2021

Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.

Food & function

Xie C,Ma H,Shi Y,Li J,Wu H,Wang B,Shao Z,Huang C,Chen J,Sun L,Zhou Y,Tian N,Wu Y,Gao W,Wu A,Wang X,Zhang X

Sun Mar 21 00:00:00 UTC 2021

Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.

Food & function

Xie C,Ma H,Shi Y,Li J,Wu H,Wang B,Shao Z,Huang C,Chen J,Sun L,Zhou Y,Tian N,Wu Y,Gao W,Wu A,Wang X,Zhang X

Sun Mar 21 00:00:00 UTC 2021

Decreased miR-214-3p activates NF-κB pathway and aggravates osteoarthritis progression.

EBioMedicine

Cao Y,Tang S,Nie X,Zhou Z,Ruan G,Han W,Zhu Z,Ding C

Mon Mar 01 00:00:00 UTC 2021

Isovitexin Depresses Osteoarthritis Progression via the Nrf2/NF-κB Pathway: An in vitro Study.

Journal of inflammation research

Hu X,Li R,Sun M,Kong Y,Zhu H,Wang F,Wan Q

Fri Apr 22 00:00:00 UTC 2022

Exosome-Encapsulated microRNA-127-3p Released from Bone Marrow-Derived Mesenchymal Stem Cells Alleviates Osteoarthritis Through Regulating CDH11-Mediated Wnt/β-Catenin Pathway.

Journal of pain research

Dong J,Li L,Fang X,Zang M

Wed Apr 20 00:00:00 UTC 2022

d-Mannose suppresses osteoarthritis development in vivo and delays IL-1β-induced degeneration in vitro by enhancing autophagy activated via the AMPK pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Lin Z,Miao J,Zhang T,He M,Zhou X,Zhang H,Gao Y,Bai L

Mon Mar 01 00:00:00 UTC 2021

Endoplasmic reticulum stress pathway mediates T-2 toxin-induced chondrocyte apoptosis.

Toxicology

Liu YN,Mu YD,Wang H,Zhang M,Shi YW,Mi G,Peng LX,Chen JH

Wed Dec 01 00:00:00 UTC 2021

Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells.

Frontiers in cell and developmental biology

Xie C,Shi Y,Chen Z,Zhou X,Luo P,Hong C,Tian N,Wu Y,Zhou Y,Lin Y,Dou H,Wu A,Huang Q,Zhang X,Wang X

Tue Feb 01 00:00:00 UTC 2022

Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells.

Frontiers in cell and developmental biology

Xie C,Shi Y,Chen Z,Zhou X,Luo P,Hong C,Tian N,Wu Y,Zhou Y,Lin Y,Dou H,Wu A,Huang Q,Zhang X,Wang X

Tue Feb 01 00:00:00 UTC 2022

Physiological Reloading Recovers Histologically Disuse Atrophy of the Articular Cartilage and Bone by Hindlimb Suspension in Rat Knee Joint.

Cartilage

Takahashi I,Matsuzaki T,Kuroki H,Hoso M

Wed Dec 01 00:00:00 UTC 2021

Leptin Induced TLR4 Expression via the JAK2-STAT3 Pathway in Obesity-Related Osteoarthritis.

Oxidative medicine and cellular longevity

Jiang M,He J,Sun Y,Dong X,Yao J,Gu H,Liu L

Mon Sep 13 00:00:00 UTC 2021

MicroRNA-4423-3p inhibits proliferation of fibroblast-like synoviocytes by targeting matrix metalloproteinase 13 in rheumatoid arthritis.

Bioengineered

Xu W,Ye L,Wu H

Wed Dec 01 00:00:00 UTC 2021

Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration.

Journal of nanobiotechnology

Xing H,Zhang Z,Mao Q,Wang C,Zhou Y,Zhou X,Ying L,Xu H,Hu S,Zhang N

Mon Sep 06 00:00:00 UTC 2021

Acetabular development and fate of inverted limbus in rabbits: Experimental observation from an animal model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Liu J,Zhou W,Chen Y,Li L

Wed Dec 01 00:00:00 UTC 2021

Acetabular development and fate of inverted limbus in rabbits: Experimental observation from an animal model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Liu J,Zhou W,Chen Y,Li L

Wed Dec 01 00:00:00 UTC 2021

Oroxylin A attenuates IL-1β-induced inflammatory reaction via inhibiting the activation of the ERK and PI3K/AKT signaling pathways in osteoarthritis chondrocytes.

Experimental and therapeutic medicine

Zhang Y,Weng Q,Chen J,Li M,Han J

Thu Apr 01 00:00:00 UTC 2021

Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway.

Scientific reports

Hattori K,Takahashi N,Terabe K,Ohashi Y,Kishimoto K,Yokota Y,Suzuki M,Kojima T,Imagama S

Fri Jul 30 00:00:00 UTC 2021

Osteocyte Apoptosis Contributes to Cold Exposure-induced Bone Loss.

Frontiers in bioengineering and biotechnology

Du J,He Z,Cui J,Li H,Xu M,Zhang S,Zhang S,Yan M,Qu X,Yu Z

Wed Jan 05 00:00:00 UTC 2022

Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3.

Journal of inflammation research

Jin Y,Li Z,Wu Y,Li H,Liu Z,Liu L,Ouyang N,Zhou T,Fang B,Xia L

Thu Apr 28 00:00:00 UTC 2022

Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3.

Journal of inflammation research

Jin Y,Li Z,Wu Y,Li H,Liu Z,Liu L,Ouyang N,Zhou T,Fang B,Xia L

Thu Apr 28 00:00:00 UTC 2022

Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3.

Journal of inflammation research

Jin Y,Li Z,Wu Y,Li H,Liu Z,Liu L,Ouyang N,Zhou T,Fang B,Xia L

Thu Apr 28 00:00:00 UTC 2022

MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.

Cell death & disease

Lu Y,Liu L,Pan J,Luo B,Zeng H,Shao Y,Zhang H,Guan H,Guo D,Zeng C,Zhang R,Bai X,Zhang H,Cai D

Tue May 25 00:00:00 UTC 2021

MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.

Cell death & disease

Lu Y,Liu L,Pan J,Luo B,Zeng H,Shao Y,Zhang H,Guan H,Guo D,Zeng C,Zhang R,Bai X,Zhang H,Cai D

Tue May 25 00:00:00 UTC 2021

Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin.

Frontiers in cell and developmental biology

Xu H,Wei K,Tu J,Chen Y,He Y,Ding Y,Xu H,Bao X,Xie H,Fang H,Wang H

Tue Dec 07 00:00:00 UTC 2021

Glucagon-like peptide-1 receptor activation maintains extracellular matrix integrity by inhibiting the activity of mitogen-activated protein kinases and activator protein-1.

Free radical biology & medicine

Peng Y,Lin H,Tian S,Liu S,Li J,Lv X,Chen S,Zhao L,Pu F,Chen X,Shu H,Qing X,Shao Z

Wed Dec 01 00:00:00 UTC 2021

Glucagon-like peptide-1 receptor activation maintains extracellular matrix integrity by inhibiting the activity of mitogen-activated protein kinases and activator protein-1.

Free radical biology & medicine

Peng Y,Lin H,Tian S,Liu S,Li J,Lv X,Chen S,Zhao L,Pu F,Chen X,Shu H,Qing X,Shao Z

Wed Dec 01 00:00:00 UTC 2021

Therapeutic effect of neohesperidin on TNF-α-stimulated human rheumatoid arthritis fibroblast-like synoviocytes.

Chinese journal of natural medicines

Wang XH,Dai C,Wang J,Liu R,Li L,Yin ZS

Fri Oct 01 00:00:00 UTC 2021

α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice.

Aging

Zhang H,Li S,Lu J,Jin J,Zhu G,Wang L,Yan Y,He L,Wang B,Wang X,Yu H

Thu Jul 08 00:00:00 UTC 2021

Compressive force regulates cementoblast migration via downregulation of autophagy.

Journal of periodontology

Yang Y,Huang Y,Liu H,Zheng Y,Jia L,Li W

Mon Nov 01 00:00:00 UTC 2021

Staphylococcus aureus on the effect of expression of MMPs/TIMPs and uPA system in bovine mammary fibroblasts.

Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

Miao Z,Ding Y,Bi Y,Chen M,Cao X,Wang F

Tue Jun 01 00:00:00 UTC 2021

Integrative analysis of genome-wide DNA methylation and single-nucleotide polymorphism identified ACSM5 as a suppressor of lumbar ligamentum flavum hypertrophy.

Arthritis research & therapy

Cao Y,Zhan Y,Qiu S,Chen Z,Gong K,Ni S,Duan Y

Thu Sep 30 00:00:00 UTC 2021

Effects of HDAC4 on IL-1β-induced matrix metalloproteinase expression regulated partially through the WNT3A/β-catenin pathway.

Chinese medical journal

Ning Q,Gan YH,Shi RR,Meng JH

Thu Apr 08 00:00:00 UTC 2021

SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.

Stem cells and development

Ding N,Zeng MY,Song WJ,Xiao CX,Li EM,Wei B

Fri Oct 15 00:00:00 UTC 2021

SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.

Stem cells and development

Ding N,Zeng MY,Song WJ,Xiao CX,Li EM,Wei B

Fri Oct 15 00:00:00 UTC 2021

Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1β-Induced Osteoarthritis Progression Through Regulating DNMT3A.

Frontiers in genetics

Zhu H,Zhu S,Shang X,Meng X,Jing S,Yu L,Deng Y

Tue Jun 08 00:00:00 UTC 2021

TGF-β/Alk5 signaling prevents osteoarthritis initiation via regulating the senescence of articular cartilage stem cells.

Journal of cellular physiology

Tan Q,Wang Q,Kuang L,Zhang J,Peng X,Liang S,Liu M,Chen H,Chen S,Luo X,Qi H,Li C,Luo F,Huang S,Ni Z,Jin M,Su N,Yang J,Yang P,Chen B,Chen L,Du X,Xie Y,Chen L

Thu Jul 01 00:00:00 UTC 2021

Silencing BLNK protects against interleukin-1β-induced chondrocyte injury through the NF-κB signaling pathway.

Cytokine

Cheng Y,Li F,Zhang WS,Zou GY,Shen YX

Wed Dec 01 00:00:00 UTC 2021

Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p.

Frontiers in cell and developmental biology

Wang X,Li Z,Cui Y,Cui X,Chen C,Wang Z

Sat Apr 23 00:00:00 UTC 2022

18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2.

Food & function

Chen B,Zhu D,Xie C,Shi Y,Ni L,Zhang H,Li S,Lu J,Xiao J,Xia W,Huang C,Wang X

Mon Sep 20 00:00:00 UTC 2021

18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2.

Food & function

Chen B,Zhu D,Xie C,Shi Y,Ni L,Zhang H,Li S,Lu J,Xiao J,Xia W,Huang C,Wang X

Mon Sep 20 00:00:00 UTC 2021

LncRNA Malat-1 From MSCs-Derived Extracellular Vesicles Suppresses Inflammation and Cartilage Degradation in Osteoarthritis.

Frontiers in bioengineering and biotechnology

Pan C,Huang W,Chen Q,Xu J,Yao G,Li B,Wu T,Yin C,Cheng X

Tue Jan 04 00:00:00 UTC 2022

Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis.

Scientific reports

Ohashi Y,Takahashi N,Terabe K,Tsuchiya S,Kojima T,Knudson CB,Knudson W,Imagama S

Fri Jul 23 00:00:00 UTC 2021

Inhibition of HDAC6 by Tubastatin A reduces chondrocyte oxidative stress in chondrocytes and ameliorates mouse osteoarthritis by activating autophagy.

Aging

Shen Z,Ji K,Cai Z,Huang C,He X,Xu H,Chen G

Fri Mar 19 00:00:00 UTC 2021

AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhang Z,Wu H,Huang S,Chen L,Chen X,Zhang W,Liao L,Zhang X

Tue Jun 01 00:00:00 UTC 2021

LncRNA H19-Derived miR-675-5p Accelerates the Invasion of Extravillous Trophoblast Cells by Inhibiting GATA2 and Subsequently Activating Matrix Metalloproteinases.

International journal of molecular sciences

Ogoyama M,Ohkuchi A,Takahashi H,Zhao D,Matsubara S,Takizawa T

Wed Jan 27 00:00:00 UTC 2021

Involvement of Transient Receptor Potential Vanilloid Channel 2 in the Induction of Lubricin and Suppression of Ectopic Endochondral Ossification in Mouse Articular Cartilage.

Arthritis & rheumatology (Hoboken, N.J.)

Nakamoto H,Katanosaka Y,Chijimatsu R,Mori D,Xuan F,Yano F,Omata Y,Maenohara Y,Murahashi Y,Kawaguchi K,Yamagami R,Inui H,Taketomi S,Taniguchi Y,Kanagawa M,Naruse K,Tanaka S,Saito T

Sun Aug 01 00:00:00 UTC 2021

MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.

Oxidative medicine and cellular longevity

Ni B,Pei W,Qu Y,Zhang R,Chu X,Wang Y,Huang X,You H

Mon Feb 14 00:00:00 UTC 2022

MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.

Oxidative medicine and cellular longevity

Ni B,Pei W,Qu Y,Zhang R,Chu X,Wang Y,Huang X,You H

Mon Feb 14 00:00:00 UTC 2022

Zonal-Layered Chondrocyte Sheets for Repairment of Full-Thickness Articular Cartilage Defect: A Mini-Pig Model.

Biomedicines

Shen PC,Lu CC,Chou SH,Liu ZM,Su SJ,Tien YC

Tue Nov 30 00:00:00 UTC 2021

Frugoside delays osteoarthritis progression via inhibiting miR-155-modulated synovial macrophage M1 polarization.

Rheumatology (Oxford, England)

Wang H,Zhang H,Fan K,Zhang D,Hu A,Zeng X,Liu YL,Tan G,Wang H

Sat Oct 02 00:00:00 UTC 2021

A chondroprotective effect of moracin on IL-1β-induced primary rat chondrocytes and an osteoarthritis rat model through Nrf2/HO-1 and NF-κB axes.

Food & function

Zhou S,Shi J,Wen H,Xie W,Han X,Li H

Wed Sep 23 00:00:00 UTC 2020

A chondroprotective effect of moracin on IL-1β-induced primary rat chondrocytes and an osteoarthritis rat model through Nrf2/HO-1 and NF-κB axes.

Food & function

Zhou S,Shi J,Wen H,Xie W,Han X,Li H

Wed Sep 23 00:00:00 UTC 2020

miR-873-3p targets HDAC4 to stimulate matrix metalloproteinase-13 expression upon parathyroid hormone exposure in rat osteoblasts.

Journal of cellular physiology

Malavika D,Shreya S,Raj Priya V,Rohini M,He Z,Partridge NC,Selvamurugan N

Sun Nov 01 00:00:00 UTC 2020

Protective effect of resveratrol on obesity-related osteoarthritis via alleviating JAK2/STAT3 signaling pathway is independent of SOCS3.

Toxicology and applied pharmacology

Jiang M,He J,Gu H,Yang Y,Huang Y,Xu X,Liu L

Sat Feb 01 00:00:00 UTC 2020

Targeting exosome-associated human antigen R attenuates fibrosis and inflammation in diabetic heart.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Govindappa PK,Patil M,Garikipati VNS,Verma SK,Saheera S,Narasimhan G,Zhu W,Kishore R,Zhang J,Krishnamurthy P

Sat Feb 01 00:00:00 UTC 2020

Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis.

Drug design, development and therapy

Kong J,Wang J,Gong X,Zheng X,Chen T

Tue Sep 21 00:00:00 UTC 2021

Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.

International immunopharmacology

Zhang X,Huang CR,Pan S,Pang Y,Chen YS,Zha GC,Guo KJ,Zheng X

Mon Jun 01 00:00:00 UTC 2020

S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.

Aging

Shao Z,Pan Z,Lin J,Zhao Q,Wang Y,Ni L,Feng S,Tian N,Wu Y,Sun L,Gao W,Zhou Y,Zhang X,Wang X

Wed Oct 07 00:00:00 UTC 2020

Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.

Inflammation

Wang W,Yang R,Zhang M,Li J,Peng J,Xu M,Zhao Y,Li H,Pan X

Sat Aug 01 00:00:00 UTC 2020

Paclitaxel-induced peripheral neuropathy is caused by epidermal ROS and mitochondrial damage through conserved MMP-13 activation.

Scientific reports

Cirrincione AM,Pellegrini AD,Dominy JR,Benjamin ME,Utkina-Sosunova I,Lotti F,Jergova S,Sagen J,Rieger S

Wed Mar 04 00:00:00 UTC 2020

Casticin Attenuates Osteoarthritis-Related Cartilage Degeneration by Inhibiting the ROS-Mediated NF-κB Signaling Pathway in vitro and in vivo.

Inflammation

Chu J,Yan B,Zhang J,Peng L,Ao X,Zheng Z,Jiang T,Zhang Z

Mon Jun 01 00:00:00 UTC 2020

MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5.

Biochemical and biophysical research communications

Shen XF,Cheng Y,Dong QR,Zheng MQ

Thu Jun 25 00:00:00 UTC 2020

Reducing macrophage numbers alleviates temporomandibular joint ankylosis.

Cell and tissue research

Zhao L,Xiao E,He L,Duan D,He Y,Chen S,Zhang Y,Gan Y

Sun Mar 01 00:00:00 UTC 2020

The protective effect of myricitrin in osteoarthritis: An in vitro and in vivo study.

International immunopharmacology

Yan Z,Lin Z,Wu Y,Zhan J,Qi W,Lin J,Shen J,Xue X,Pan X

Wed Jul 01 00:00:00 UTC 2020

Inhibition of PI3K/Akt/NF-κB signaling by Aloin for ameliorating the progression of osteoarthritis: In vitro and in vivo studies.

International immunopharmacology

Zhang C,Shao Z,Hu X,Chen Z,Li B,Jiang R,Bsoul N,Chen J,Xu C,Gao W

Tue Dec 01 00:00:00 UTC 2020

Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo.

Biomaterials

Schoenenberger AD,Tempfer H,Lehner C,Egloff J,Mauracher M,Bird A,Widmer J,Maniura-Weber K,Fucentese SF,Traweger A,Silvan U,Snedeker JG

Sat Aug 01 00:00:00 UTC 2020

Oxymatrine suppresses IL-1β-induced degradation of the nucleus pulposus cell and extracellular matrix through the TLR4/NF-κB signaling pathway.

Experimental biology and medicine (Maywood, N.J.)

Wei K,Dai J,Wang Z,Pei Y,Chen Y,Ding Y,Ding Q,Ahati P,Zhou X,Wang H,Fang H

Sun Mar 01 00:00:00 UTC 2020

Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies.

Food & function

Shao Z,Lu J,Zhang C,Zeng G,Chen B,Liang H,Wu A,Zhang X,Wang X

Tue Dec 01 00:00:00 UTC 2020

Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies.

Food & function

Shao Z,Lu J,Zhang C,Zeng G,Chen B,Liang H,Wu A,Zhang X,Wang X

Tue Dec 01 00:00:00 UTC 2020

Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies.

Food & function

Shao Z,Lu J,Zhang C,Zeng G,Chen B,Liang H,Wu A,Zhang X,Wang X

Tue Dec 01 00:00:00 UTC 2020

Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies.

Food & function

Shao Z,Lu J,Zhang C,Zeng G,Chen B,Liang H,Wu A,Zhang X,Wang X

Tue Dec 01 00:00:00 UTC 2020

FTO promotes cell proliferation and migration in esophageal squamous cell carcinoma through up-regulation of MMP13.

Experimental cell research

Liu S,Huang M,Chen Z,Chen J,Chao Q,Yin X,Quan M

Wed Apr 01 00:00:00 UTC 2020

Curcumol may reverse early and advanced liver fibrogenesis through downregulating the uPA/uPAR pathway.

Phytotherapy research : PTR

Li G,Lin J,Peng Y,Qin K,Wen L,Zhao T,Feng Q

Mon Jun 01 00:00:00 UTC 2020

MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.

Life sciences

Wen X,Li H,Sun H,Zeng A,Lin R,Zhao J,Zhang Z

Wed Jul 15 00:00:00 UTC 2020

MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.

Life sciences

Wen X,Li H,Sun H,Zeng A,Lin R,Zhao J,Zhang Z

Wed Jul 15 00:00:00 UTC 2020

MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.

Life sciences

Wen X,Li H,Sun H,Zeng A,Lin R,Zhao J,Zhang Z

Wed Jul 15 00:00:00 UTC 2020

MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.

Life sciences

Wen X,Li H,Sun H,Zeng A,Lin R,Zhao J,Zhang Z

Wed Jul 15 00:00:00 UTC 2020

TLR4 contributes to the damage of cartilage and subchondral bone in discectomy-induced TMJOA mice.

Journal of cellular and molecular medicine

Liu X,Cai HX,Cao PY,Feng Y,Jiang HH,Liu L,Ke J,Long X

Thu Oct 01 00:00:00 UTC 2020

Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts.

International journal of molecular medicine

Wang X,Lin L,Chai X,Wu Y,Li Y,Liu X

Wed Jan 01 00:00:00 UTC 2020

Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts.

International journal of molecular medicine

Wang X,Lin L,Chai X,Wu Y,Li Y,Liu X

Wed Jan 01 00:00:00 UTC 2020

Keratocytes promote corneal neovascularization through VEGFr3 induced by PPARα-inhibition.

Experimental eye research

Wang X,Tang L,Zhang Z,Li W,Chen Y

Wed Apr 01 00:00:00 UTC 2020

Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice.

Arthritis research & therapy

Bellini M,Pest MA,Miranda-Rodrigues M,Qin L,Jeong JW,Beier F

Tue May 19 00:00:00 UTC 2020

Heparan sulfate deficiency leads to hypertrophic chondrocytes by increasing bone morphogenetic protein signaling.

Osteoarthritis and cartilage

Kawashima K,Ogawa H,Komura S,Ishihara T,Yamaguchi Y,Akiyama H,Matsumoto K

Sun Nov 01 00:00:00 UTC 2020

LncRNA TRPC7-AS1 regulates nucleus pulposus cellular senescence and ECM synthesis via competing with HPN for miR-4769-5p binding.

Mechanisms of ageing and development

Wang X,Li D,Wu H,Liu F,Liu F,Zhang Q,Li J

Tue Sep 01 00:00:00 UTC 2020

OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.

Pain research & management

Tian J,Cheng C,Kuang SD,Su C,Zhao X,Xiong YL,Li YS,Gao SG

Wed Mar 10 00:00:00 UTC 2021

IκB kinase α: an independent prognostic factor that promotes the migration and invasion of oral squamous cell carcinoma.

The British journal of oral & maxillofacial surgery

Lv S,Wang F,Wang K,Fan Y,Xu J,Zheng J,Zeng Y

Wed Apr 01 00:00:00 UTC 2020

Vitamin D3 protects articular cartilage by inhibiting the Wnt/β-catenin signaling pathway.

Experimental and therapeutic medicine

Yang T,Sun W,Duan YH,Sun YB,Ren YM,Hou WY,Tian MQ

Sat Aug 01 00:00:00 UTC 2020

Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis.

Cell death and differentiation

Mancarella S,Serino G,Dituri F,Cigliano A,Ribback S,Wang J,Chen X,Calvisi DF,Giannelli G

Sat Aug 01 00:00:00 UTC 2020

Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.

Acta biochimica et biophysica Sinica

Li Y,Liu M,Yi J,Song X,Zheng X,Liu D,Wang S,Chu C,Yang J

Tue Dec 29 00:00:00 UTC 2020

IL-37 inhibits M1-like macrophage activation to ameliorate temporomandibular joint inflammation through the NLRP3 pathway.

Rheumatology (Oxford, England)

Luo P,Peng S,Yan Y,Ji P,Xu J

Thu Oct 01 00:00:00 UTC 2020

IL-37 inhibits M1-like macrophage activation to ameliorate temporomandibular joint inflammation through the NLRP3 pathway.

Rheumatology (Oxford, England)

Luo P,Peng S,Yan Y,Ji P,Xu J

Thu Oct 01 00:00:00 UTC 2020

MicroRNA-377-3p alleviates IL-1β-caused chondrocyte apoptosis and cartilage degradation in osteoarthritis in part by downregulating ITGA6.

Biochemical and biophysical research communications

Tu Y,Ma T,Wen T,Yang T,Xue L,Cai M,Wang F,Guan M,Xue H

Wed Feb 26 00:00:00 UTC 2020

Effects of IL-1β on MMP-9 Expression in Cementoblast-Derived Cell Line and MMP-Mediated Degradation of Type I Collagen.

Inflammation

Du M,Wang Y,Liu Z,Wang L,Cao Z,Zhang C,Hao Y,He H

Mon Apr 01 00:00:00 UTC 2019

Effects of IL-1β on MMP-9 Expression in Cementoblast-Derived Cell Line and MMP-Mediated Degradation of Type I Collagen.

Inflammation

Du M,Wang Y,Liu Z,Wang L,Cao Z,Zhang C,Hao Y,He H

Mon Apr 01 00:00:00 UTC 2019

Reduced PDGF-AA in subchondral bone leads to articular cartilage degeneration after strenuous running.

Journal of cellular physiology

Yao Z,Chen P,Wang S,Deng G,Hu Y,Lin Q,Zhang X,Yu B

Thu Aug 01 00:00:00 UTC 2019

Inhibition of Ihh Reverses Temporomandibular Joint Osteoarthritis via a PTH1R Signaling Dependent Mechanism.

International journal of molecular sciences

Yang H,Zhang M,Liu Q,Zhang H,Zhang J,Lu L,Xie M,Chen D,Wang M

Sat Aug 03 00:00:00 UTC 2019

25-HC decreases the sensitivity of human gastric cancer cells to 5-fluorouracil and promotes cells invasion via the TLR2/NF-κB signaling pathway.

International journal of oncology

Wang S,Yao Y,Rao C,Zheng G,Chen W

Fri Mar 01 00:00:00 UTC 2019

Nobiletin Inhibits IL-1β-Induced Inflammation in Chondrocytes via Suppression of NF-κB Signaling and Attenuates Osteoarthritis in Mice.

Frontiers in pharmacology

Lin Z,Wu D,Huang L,Jiang C,Pan T,Kang X,Pan J

Tue Sep 29 00:00:00 UTC 2020

ZnO nanoparticles inhibit the activity of Porphyromonas gingivalis and Actinomyces naeslundii and promote the mineralization of the cementum.

BMC oral health

Wang J,Du L,Fu Y,Jiang P,Wang X

Tue May 14 00:00:00 UTC 2019

Effects of simvastatin on matrix metalloproteinase regulation in IL-1β-induced SW1353 cells.

Chemico-biological interactions

Cecen B,Keles D,Oktay G,Kozaci LD

Sun Sep 01 00:00:00 UTC 2019

KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.

Oxidative medicine and cellular longevity

Gao X,Jiang S,Du Z,Ke A,Liang Q,Li X

Mon May 04 00:00:00 UTC 2020

KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo.

Oxidative medicine and cellular longevity

Gao X,Jiang S,Du Z,Ke A,Liang Q,Li X

Mon May 04 00:00:00 UTC 2020

Development of a Mouse Model of Knee Osteoarthritis Based on Obesity and Bipedal Walking.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Son KM,Jung HA,Hong JI,Park IY,Kim HA

Fri Nov 01 00:00:00 UTC 2019

Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-5.

Scientific reports

Miyauchi A,Kim-Kaneyama JR,Lei XF,Chang SH,Saito T,Haraguchi S,Miyazaki T,Miyazaki A

Thu Oct 31 00:00:00 UTC 2019

25-HC promotes hepatocellular carcinoma metastasis through up-regulation of TLR4 dependent FABP4.

American journal of cancer research

Wang S,Yao Y,Wang X,Zheng G,Ouyang W,Chen W

Tue Sep 29 00:00:00 UTC 2020

Adamts17 is involved in skeletogenesis through modulation of BMP-Smad1/5/8 pathway.

Cellular and molecular life sciences : CMLS

Oichi T,Taniguchi Y,Soma K,Oshima Y,Yano F,Mori Y,Chijimatsu R,Kim-Kaneyama JR,Tanaka S,Saito T

Sun Dec 01 00:00:00 UTC 2019

miR-93-5p attenuates IL-1β-induced chondrocyte apoptosis and cartilage degradation in osteoarthritis partially by targeting TCF4.

Bone

Xue H,Tu Y,Ma T,Wen T,Yang T,Xue L,Cai M,Wang F,Guan M

Sat Jun 01 00:00:00 UTC 2019

Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.

Free radical biology & medicine

Hu Y,Gui Z,Zhou Y,Xia L,Lin K,Xu Y

Sun Dec 01 00:00:00 UTC 2019

Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages.

Free radical biology & medicine

Hu Y,Gui Z,Zhou Y,Xia L,Lin K,Xu Y

Sun Dec 01 00:00:00 UTC 2019

Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.

Experimental & molecular medicine

Wu X,Liao Z,Wang K,Hua W,Liu X,Song Y,Zhang Y,Yang S,Yang C

Wed Sep 25 00:00:00 UTC 2019

Cortistatin binds to TNF-α receptors and protects against osteoarthritis.

EBioMedicine

Zhao Y,Li Y,Qu R,Chen X,Wang W,Qiu C,Liu B,Pan X,Liu L,Vasilev K,Hayball J,Dong S,Li W

Fri Mar 01 00:00:00 UTC 2019

miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis.

Biomaterials

Wu J,Kuang L,Chen C,Yang J,Zeng WN,Li T,Chen H,Huang S,Fu Z,Li J,Liu R,Ni Z,Chen L,Yang L

Sat Jun 01 00:00:00 UTC 2019

A Compound of Chinese Herbs Protects against Alcoholic Liver Fibrosis in Rats via the TGF-β1/Smad Signaling Pathway.

Evidence-based complementary and alternative medicine : eCAM

Li X,Liu Y,Yue W,Tan Y,Wang H,Zhang L,Chen J

Tue Jul 16 00:00:00 UTC 2024

Toxoplasma gondii GRA15_II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica.

Cellular & molecular immunology

Xie Y,Wen H,Yan K,Wang S,Wang X,Chen J,Li Y,Xu Y,Zhong Z,Shen J,Chu D

Thu Feb 01 00:00:00 UTC 2018

Toxoplasma gondii GRA15_II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica.

Cellular & molecular immunology

Xie Y,Wen H,Yan K,Wang S,Wang X,Chen J,Li Y,Xu Y,Zhong Z,Shen J,Chu D

Thu Feb 01 00:00:00 UTC 2018

ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.

Breast cancer research : BCR

Dumortier M,Ladam F,Damour I,Vacher S,Bièche I,Marchand N,de Launoit Y,Tulasne D,Chotteau-Lelièvre A

Wed Jul 11 00:00:00 UTC 2018

ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.

Breast cancer research : BCR

Dumortier M,Ladam F,Damour I,Vacher S,Bièche I,Marchand N,de Launoit Y,Tulasne D,Chotteau-Lelièvre A

Wed Jul 11 00:00:00 UTC 2018

ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.

Breast cancer research : BCR

Dumortier M,Ladam F,Damour I,Vacher S,Bièche I,Marchand N,de Launoit Y,Tulasne D,Chotteau-Lelièvre A

Wed Jul 11 00:00:00 UTC 2018

ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis.

Breast cancer research : BCR

Dumortier M,Ladam F,Damour I,Vacher S,Bièche I,Marchand N,de Launoit Y,Tulasne D,Chotteau-Lelièvre A

Wed Jul 11 00:00:00 UTC 2018

Postnatal deletion of Alk5 gene in meniscal cartilage accelerates age-dependent meniscal degeneration in mice.

Journal of cellular physiology

Wang Q,Tan Q,Xu W,Kuang L,Zhang B,Wang Z,Ni Z,Su N,Jin M,Li C,Jiang W,Huang J,Li F,Zhu Y,Chen H,Du X,Chen D,Deng C,Qi H,Xie Y,Chen L

Mon Jan 01 00:00:00 UTC 2018

Postnatal deletion of Alk5 gene in meniscal cartilage accelerates age-dependent meniscal degeneration in mice.

Journal of cellular physiology

Wang Q,Tan Q,Xu W,Kuang L,Zhang B,Wang Z,Ni Z,Su N,Jin M,Li C,Jiang W,Huang J,Li F,Zhu Y,Chen H,Du X,Chen D,Deng C,Qi H,Xie Y,Chen L

Mon Jan 01 00:00:00 UTC 2018

Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.

International immunopharmacology

Ding QH,Ye CY,Chen EM,Zhang W,Wang XH

Wed Aug 01 00:00:00 UTC 2018

Emodin ameliorates cartilage degradation in osteoarthritis by inhibiting NF-κB and Wnt/β-catenin signaling in-vitro and in-vivo.

International immunopharmacology

Ding QH,Ye CY,Chen EM,Zhang W,Wang XH

Wed Aug 01 00:00:00 UTC 2018

mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Katsara O,Kolupaeva V

Mon Oct 01 00:00:00 UTC 2018

mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Katsara O,Kolupaeva V

Mon Oct 01 00:00:00 UTC 2018

mTOR-mediated inactivation of 4E-BP1, an inhibitor of translation, precedes cartilage degeneration in rat osteoarthritic knees.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Katsara O,Kolupaeva V

Mon Oct 01 00:00:00 UTC 2018

SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.

International journal of biological sciences

Wang J,Wang K,Huang C,Lin D,Zhou Y,Wu Y,Tian N,Fan P,Pan X,Xu D,Hu J,Zhou Y,Wang X,Zhang X

Mon Sep 09 00:00:00 UTC 2019

SIRT3 Activation by Dihydromyricetin Suppresses Chondrocytes Degeneration via Maintaining Mitochondrial Homeostasis.

International journal of biological sciences

Wang J,Wang K,Huang C,Lin D,Zhou Y,Wu Y,Tian N,Fan P,Pan X,Xu D,Hu J,Zhou Y,Wang X,Zhang X

Mon Sep 09 00:00:00 UTC 2019

Loss of Fgfr1 in chondrocytes inhibits osteoarthritis by promoting autophagic activity in temporomandibular joint.

The Journal of biological chemistry

Wang Z,Huang J,Zhou S,Luo F,Tan Q,Sun X,Ni Z,Chen H,Du X,Xie Y,Chen L

Fri Jun 08 00:00:00 UTC 2018

Differential effects of high-physiological oestrogen on the degeneration of mandibular condylar cartilage and subchondral bone.

Bone

Ye T,Sun D,Mu T,Chu Y,Miao H,Zhang M,Yang H,Liu Q,Lu L,Xing X,Yu S

Fri Jun 01 00:00:00 UTC 2018

Differential effects of high-physiological oestrogen on the degeneration of mandibular condylar cartilage and subchondral bone.

Bone

Ye T,Sun D,Mu T,Chu Y,Miao H,Zhang M,Yang H,Liu Q,Lu L,Xing X,Yu S

Fri Jun 01 00:00:00 UTC 2018

Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice.

Osteoarthritis and cartilage

Wang Q,Tan QY,Xu W,Qi HB,Chen D,Zhou S,Ni ZH,Kuang L,Guo JY,Huang JL,Wang XX,Wang ZQ,Su N,Chen L,Chen B,Jiang WL,Gao Y,Chen HG,Du XL,Xie YL,Chen L

Wed Nov 01 00:00:00 UTC 2017

Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice.

Osteoarthritis and cartilage

Wang Q,Tan QY,Xu W,Qi HB,Chen D,Zhou S,Ni ZH,Kuang L,Guo JY,Huang JL,Wang XX,Wang ZQ,Su N,Chen L,Chen B,Jiang WL,Gao Y,Chen HG,Du XL,Xie YL,Chen L

Wed Nov 01 00:00:00 UTC 2017

Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice.

Osteoarthritis and cartilage

Wang Q,Tan QY,Xu W,Qi HB,Chen D,Zhou S,Ni ZH,Kuang L,Guo JY,Huang JL,Wang XX,Wang ZQ,Su N,Chen L,Chen B,Jiang WL,Gao Y,Chen HG,Du XL,Xie YL,Chen L

Wed Nov 01 00:00:00 UTC 2017

Cartilage-specific deletion of Alk5 gene results in a progressive osteoarthritis-like phenotype in mice.

Osteoarthritis and cartilage

Wang Q,Tan QY,Xu W,Qi HB,Chen D,Zhou S,Ni ZH,Kuang L,Guo JY,Huang JL,Wang XX,Wang ZQ,Su N,Chen L,Chen B,Jiang WL,Gao Y,Chen HG,Du XL,Xie YL,Chen L

Wed Nov 01 00:00:00 UTC 2017

Upregulation of FBXW7 Suppresses Renal Cancer Metastasis and Epithelial Mesenchymal Transition.

Disease markers

Cai Y,Zhang M,Qiu X,Wang B,Fu Y,Zeng J,Bai J,Yang G

Fri Jun 22 00:00:00 UTC 2018

Upregulation of FBXW7 Suppresses Renal Cancer Metastasis and Epithelial Mesenchymal Transition.

Disease markers

Cai Y,Zhang M,Qiu X,Wang B,Fu Y,Zeng J,Bai J,Yang G

Fri Jun 22 00:00:00 UTC 2018

Chlorogenic acid prevents inflammatory responses in IL‑1β‑stimulated human SW‑1353 chondrocytes, a model for osteoarthritis.

Molecular medicine reports

Liu CC,Zhang Y,Dai BL,Ma YJ,Zhang Q,Wang Y,Yang H

Tue Aug 01 00:00:00 UTC 2017

Chlorogenic acid prevents inflammatory responses in IL‑1β‑stimulated human SW‑1353 chondrocytes, a model for osteoarthritis.

Molecular medicine reports

Liu CC,Zhang Y,Dai BL,Ma YJ,Zhang Q,Wang Y,Yang H

Tue Aug 01 00:00:00 UTC 2017

Icariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells.

Molecular medicine reports

Zeng L,Rong XF,Li RH,Wu XY

Mon May 01 00:00:00 UTC 2017

Icariin inhibits MMP‑1, MMP‑3 and MMP‑13 expression through MAPK pathways in IL‑1β‑stimulated SW1353 chondrosarcoma cells.

Molecular medicine reports

Zeng L,Rong XF,Li RH,Wu XY

Mon May 01 00:00:00 UTC 2017

Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration.

Spine

Suzuki S,Fujita N,Fujii T,Watanabe K,Yagi M,Tsuji T,Ishii K,Miyamoto T,Horiuchi K,Nakamura M,Matsumoto M

Sat Jul 15 00:00:00 UTC 2017

Potential Involvement of the IL-6/JAK/STAT3 Pathway in the Pathogenesis of Intervertebral Disc Degeneration.

Spine

Suzuki S,Fujita N,Fujii T,Watanabe K,Yagi M,Tsuji T,Ishii K,Miyamoto T,Horiuchi K,Nakamura M,Matsumoto M

Sat Jul 15 00:00:00 UTC 2017

Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model.

Evidence-based complementary and alternative medicine : eCAM

Zeng L,Xiao CZ,Deng ZT,Li RH

Thu Oct 01 00:00:00 UTC 2020

Chondroprotective Effects and Multitarget Mechanisms of Fu Yuan Capsule in a Rat Osteoarthritis Model.

Evidence-based complementary and alternative medicine : eCAM

Zeng L,Xiao CZ,Deng ZT,Li RH

Thu Oct 01 00:00:00 UTC 2020

Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.

Inflammation

Tu J,Li W,Zhang Y,Wu X,Song Y,Kang L,Liu W,Wang K,Li S,Hua W,Yang C

Thu Jun 01 00:00:00 UTC 2017

Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model.

Scientific reports

Higuchi Y,Nishida Y,Kozawa E,Zhuo L,Arai E,Hamada S,Morita D,Ikuta K,Kimata K,Ushida T,Ishiguro N

Tue Aug 01 00:00:00 UTC 2017

Conditional knockdown of hyaluronidase 2 in articular cartilage stimulates osteoarthritic progression in a mice model.

Scientific reports

Higuchi Y,Nishida Y,Kozawa E,Zhuo L,Arai E,Hamada S,Morita D,Ikuta K,Kimata K,Ushida T,Ishiguro N

Tue Aug 01 00:00:00 UTC 2017

Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway.

Oncoimmunology

Shen Y,Guo D,Weng L,Wang S,Ma Z,Yang Y,Wang P,Wang J,Cai Z

Tue Jan 12 00:00:00 UTC 2021

Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway.

Oncoimmunology

Shen Y,Guo D,Weng L,Wang S,Ma Z,Yang Y,Wang P,Wang J,Cai Z

Tue Jan 12 00:00:00 UTC 2021

AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.

Scientific reports

Zhou S,Lu W,Chen L,Ge Q,Chen D,Xu Z,Shi D,Dai J,Li J,Ju H,Cao Y,Qin J,Chen S,Teng H,Jiang Q

Wed Feb 22 00:00:00 UTC 2017

AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.

Scientific reports

Zhou S,Lu W,Chen L,Ge Q,Chen D,Xu Z,Shi D,Dai J,Li J,Ju H,Cao Y,Qin J,Chen S,Teng H,Jiang Q

Wed Feb 22 00:00:00 UTC 2017

Conditional knockout of tissue factor pathway inhibitor 2 in vascular endothelial cells accelerates atherosclerotic plaque development in mice.

Thrombosis research

Hong J,Liu R,Chen L,Wu B,Yu J,Gao W,Pan J,Luo X,Shi H

Fri Jan 01 00:00:00 UTC 2016

Conditional knockout of tissue factor pathway inhibitor 2 in vascular endothelial cells accelerates atherosclerotic plaque development in mice.

Thrombosis research

Hong J,Liu R,Chen L,Wu B,Yu J,Gao W,Pan J,Luo X,Shi H

Fri Jan 01 00:00:00 UTC 2016

Exogenous fibroblast growth factor 9 attenuates cartilage degradation and aggravates osteophyte formation in post-traumatic osteoarthritis.

Osteoarthritis and cartilage

Zhou S,Wang Z,Tang J,Li W,Huang J,Xu W,Luo F,Xu M,Wang J,Wen X,Chen L,Chen H,Su N,Shen Y,Du X,Xie Y,Chen L

Thu Dec 01 00:00:00 UTC 2016

Exogenous fibroblast growth factor 9 attenuates cartilage degradation and aggravates osteophyte formation in post-traumatic osteoarthritis.

Osteoarthritis and cartilage

Zhou S,Wang Z,Tang J,Li W,Huang J,Xu W,Luo F,Xu M,Wang J,Wen X,Chen L,Chen H,Su N,Shen Y,Du X,Xie Y,Chen L

Thu Dec 01 00:00:00 UTC 2016

Fibroblast Growth Factor Receptor 3 Inhibits Osteoarthritis Progression in the Knee Joints of Adult Mice.

Arthritis & rheumatology (Hoboken, N.J.)

Tang J,Su N,Zhou S,Xie Y,Huang J,Wen X,Wang Z,Wang Q,Xu W,Du X,Chen H,Chen L

Sat Oct 01 00:00:00 UTC 2016

Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress.

Osteoarthritis and cartilage

Camacho A,Simão M,Ea HK,Cohen-Solal M,Richette P,Branco J,Cancela ML

Tue Mar 01 00:00:00 UTC 2016

Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice.

Scientific reports

Zhou S,Xie Y,Li W,Huang J,Wang Z,Tang J,Xu W,Sun X,Tan Q,Huang S,Luo F,Xu M,Wang J,Wu T,Chen L,Chen H,Su N,Du X,Shen Y,Chen L

Mon Apr 04 00:00:00 UTC 2016

Conditional Deletion of Fgfr3 in Chondrocytes leads to Osteoarthritis-like Defects in Temporomandibular Joint of Adult Mice.

Scientific reports

Zhou S,Xie Y,Li W,Huang J,Wang Z,Tang J,Xu W,Sun X,Tan Q,Huang S,Luo F,Xu M,Wang J,Wu T,Chen L,Chen H,Su N,Du X,Shen Y,Chen L

Mon Apr 04 00:00:00 UTC 2016

Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis.

Journal of molecular medicine (Berlin, Germany)

Moon PM,Penuela S,Barr K,Khan S,Pin CL,Welch I,Attur M,Abramson SB,Laird DW,Beier F

Sat Aug 01 00:00:00 UTC 2015

Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis.

Journal of molecular medicine (Berlin, Germany)

Moon PM,Penuela S,Barr K,Khan S,Pin CL,Welch I,Attur M,Abramson SB,Laird DW,Beier F

Sat Aug 01 00:00:00 UTC 2015

17β-estradiol protects against apoptosis induced by interleukin-1β in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13.

Apoptosis : an international journal on programmed cell death

Yang SD,Yang DL,Sun YP,Wang BL,Ma L,Feng SQ,Ding WY

Sun Mar 01 00:00:00 UTC 2015

17β-estradiol protects against apoptosis induced by interleukin-1β in rat nucleus pulposus cells by down-regulating MMP-3 and MMP-13.

Apoptosis : an international journal on programmed cell death

Yang SD,Yang DL,Sun YP,Wang BL,Ma L,Feng SQ,Ding WY

Sun Mar 01 00:00:00 UTC 2015

Deletion of Dual Specificity Phosphatase 1 Does Not Predispose Mice to Increased Spontaneous Osteoarthritis.

PloS one

Pest MA,Pest CA,Bellini MR,Feng Q,Beier F

Wed Jul 06 00:00:00 UTC 2016

Deletion of Dual Specificity Phosphatase 1 Does Not Predispose Mice to Increased Spontaneous Osteoarthritis.

PloS one

Pest MA,Pest CA,Bellini MR,Feng Q,Beier F

Wed Jul 06 00:00:00 UTC 2016

Levofloxacin increases apoptosis of rat annulus fibrosus cells via the mechanism of upregulating MMP-2 and MMP-13.

International journal of clinical and experimental medicine

Wei HK,Yang SD,Bai ZL,Zhang X,Yang DL,Ding WY

Wed Feb 17 00:00:00 UTC 2016

Levofloxacin increases apoptosis of rat annulus fibrosus cells via the mechanism of upregulating MMP-2 and MMP-13.

International journal of clinical and experimental medicine

Wei HK,Yang SD,Bai ZL,Zhang X,Yang DL,Ding WY

Wed Feb 17 00:00:00 UTC 2016

Potent effects of dioscin against liver fibrosis.

Scientific reports

Zhang X,Han X,Yin L,Xu L,Qi Y,Xu Y,Sun H,Lin Y,Liu K,Peng J

Wed Apr 08 00:00:00 UTC 2015

Potent effects of dioscin against liver fibrosis.

Scientific reports

Zhang X,Han X,Yin L,Xu L,Qi Y,Xu Y,Sun H,Lin Y,Liu K,Peng J

Wed Apr 08 00:00:00 UTC 2015

Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis.

Osteoarthritis and cartilage

Weng T,Xie Y,Yi L,Huang J,Luo F,Du X,Chen L,Liu C,Chen D,Chen L

Fri Aug 01 00:00:00 UTC 2014

Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis.

Osteoarthritis and cartilage

Weng T,Xie Y,Yi L,Huang J,Luo F,Du X,Chen L,Liu C,Chen D,Chen L

Fri Aug 01 00:00:00 UTC 2014

Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model.

International immunopharmacology

Zeng L,Wang W,Rong XF,Zhong Y,Jia P,Zhou GQ,Li RH

Wed Jan 01 00:00:00 UTC 2014

Chondroprotective effects and multi-target mechanisms of Icariin in IL-1 beta-induced human SW 1353 chondrosarcoma cells and a rat osteoarthritis model.

International immunopharmacology

Zeng L,Wang W,Rong XF,Zhong Y,Jia P,Zhou GQ,Li RH

Wed Jan 01 00:00:00 UTC 2014

Keratocytes create stromal spaces to promote corneal neovascularization via MMP13 expression.

Investigative ophthalmology & visual science

Ma J,Zhou D,Fan M,Wang H,Huang C,Zhang Z,Wu Y,Li W,Chen Y,Liu Z

Thu Sep 04 00:00:00 UTC 2014

Keratocytes create stromal spaces to promote corneal neovascularization via MMP13 expression.

Investigative ophthalmology & visual science

Ma J,Zhou D,Fan M,Wang H,Huang C,Zhang Z,Wu Y,Li W,Chen Y,Liu Z

Thu Sep 04 00:00:00 UTC 2014

Keratocytes create stromal spaces to promote corneal neovascularization via MMP13 expression.

Investigative ophthalmology & visual science

Ma J,Zhou D,Fan M,Wang H,Huang C,Zhang Z,Wu Y,Li W,Chen Y,Liu Z

Thu Sep 04 00:00:00 UTC 2014

Keratocytes create stromal spaces to promote corneal neovascularization via MMP13 expression.

Investigative ophthalmology & visual science

Ma J,Zhou D,Fan M,Wang H,Huang C,Zhang Z,Wu Y,Li W,Chen Y,Liu Z

Thu Sep 04 00:00:00 UTC 2014

Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies.

BMC complementary and alternative medicine

Wu DQ,Zhong HM,Ding QH,Ba L

Sat Nov 15 00:00:00 UTC 2014

Protective effects of biochanin A on articular cartilage: in vitro and in vivo studies.

BMC complementary and alternative medicine

Wu DQ,Zhong HM,Ding QH,Ba L

Sat Nov 15 00:00:00 UTC 2014

Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Ding Q,Zhong H,Qi Y,Cheng Y,Li W,Yan S,Wang X

Tue Jan 01 00:00:00 UTC 2013

Anti-arthritic effects of crocin in interleukin-1β-treated articular chondrocytes and cartilage in a rabbit osteoarthritic model.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Ding Q,Zhong H,Qi Y,Cheng Y,Li W,Yan S,Wang X

Tue Jan 01 00:00:00 UTC 2013

Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes.

European journal of pharmacology

Ding QH,Cheng Y,Chen WP,Zhong HM,Wang XH

Wed May 15 00:00:00 UTC 2013

European journal of pharmacology

Ding QH,Cheng Y,Chen WP,Zhong HM,Wang XH

Wed May 15 00:00:00 UTC 2013

Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts.

Arthritis and rheumatism

Yoshioka Y,Kozawa E,Urakawa H,Arai E,Futamura N,Zhuo L,Kimata K,Ishiguro N,Nishida Y

Wed May 01 00:00:00 UTC 2013

Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts.

Arthritis and rheumatism

Yoshioka Y,Kozawa E,Urakawa H,Arai E,Futamura N,Zhuo L,Kimata K,Ishiguro N,Nishida Y

Wed May 01 00:00:00 UTC 2013

Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice.

Arthritis and rheumatism

Weng T,Yi L,Huang J,Luo F,Wen X,Du X,Chen Q,Deng C,Chen D,Chen L

Sat Dec 01 00:00:00 UTC 2012

Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice.

Arthritis and rheumatism

Weng T,Yi L,Huang J,Luo F,Wen X,Du X,Chen Q,Deng C,Chen D,Chen L

Sat Dec 01 00:00:00 UTC 2012

Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice.

Arthritis and rheumatism

Weng T,Yi L,Huang J,Luo F,Wen X,Du X,Chen Q,Deng C,Chen D,Chen L

Sat Dec 01 00:00:00 UTC 2012

Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice.

Arthritis and rheumatism

Weng T,Yi L,Huang J,Luo F,Wen X,Du X,Chen Q,Deng C,Chen D,Chen L

Sat Dec 01 00:00:00 UTC 2012

Drug delivery from internally implanted biomedical devices used in traumatology and in orthopedic surgery.

Expert opinion on drug delivery

Arruebo M,Vilaboa N,Santamaria J

Sat May 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: Collagenase; Collagenase 3; collagenase-1; Collagenase-3; Collagenase3; interstitial collagenase; matrix metallo protease; matrix metalloproteinase 13; matrix metalloproteinase 13 (collagenase 3); Matrix metalloproteinase-13; MMP; MMP-13; MMPs; Procollagenase 3; UMRCASE

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Gene Aliases: Clg; CLG3; MANDP1; MMP-13; Mmp1; MMP13

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UniProt ID: (Human) P45452, (Mouse) P33435

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Entrez Gene ID: (Human) 4322, (Mouse) 17386, (Rat) 171052

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Function(s)

fibronectin binding metalloendopeptidase activity serine-type endopeptidase activity calcium ion binding collagen binding zinc ion binding calcium-dependent protein binding low-density lipoprotein particle receptor binding peptidase activity metallopeptidase activity hydrolase activity metal ion binding

Process(es)

endochondral ossification growth plate cartilage development proteolysis extracellular matrix disassembly bone mineralization collagen catabolic process receptor internalization peptide catabolic process cellular protein metabolic process cartilage development bone morphogenesis ossification luteolysis response to hypoxia response to mechanical stimulus embryonic hindlimb morphogenesis response to drug response to estrogen osteoblast differentiation heart development parturition estrous cycle cellular response to fluid shear stress positive regulation of pancreatic trypsinogen secretion

Performance Guarantee

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MMP13 Polyclonal Antibody

MMP13 Antibody (18165-1-AP) in ICC/IF

Product Details

18165-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

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