Invitrogen

MMP9 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-116956

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 538-707 of human MMP9 (NP_0049852)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.09 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2901586

Product Specific Information

Positive Samples: B-cell, MCF7, K-562, SW480, mouse liver, mouse lung, mouse thymus, 293T

Immunogen sequence: KYWRFSEGRG SRPQGPFLIA DKWPALPRKL DSVFEERLSK KLFFFSGRQV WVYTGASVLG PRRLDKLGLG ADVAQVTGAL RSGRGKMLLF SGRRLWRFDV KAQMVDPRSA SEVDRMFPGV PLDTHDVFQY REKAYFCQDR FYWRVSSRSE LNQVDQVGYV TYDILQCPED

Target Information

MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase, a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins. MMP9 is secreted as a 92kDa zymogen and cleavage of pro-MMP9 results in the active enzyme with a molecular weight of 82kDa. MMP9 has a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells, and is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis. MMP9 is supplied by bone marrow-derived cells and contributes to skin carcinogenesis. Further, MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Studies have shown that elevated MMP9 is associated with progression of idiopathic atrial fibrillation and aortic aneurysm.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 92 kDa gelatinase; 92 kDa type IV collagenase; 92kD gelatinase; 92kD type IV collagenase; 92kDa gelatinase; 92kDa type IV collagenase; collagenase type IVB; Gel B; Gelatinase B; Gelatinase-B; GELB; macrophage gelatinase; matrix metallo protease; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metalloproteinase 9; matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); Matrix metalloproteinase-9; Matrix metalloproteinase9; MMP; MMP-9; MMPs; type V collagenase

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Gene Aliases: AW743869; B/MMP9; CLG4B; GELB; MANDP2; MMP-9; MMP9; pro-MMP-9

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UniProt ID: (Human) P14780, (Mouse) P41245

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Entrez Gene ID: (Human) 4318, (Mouse) 17395

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Function(s)
endopeptidase activity metalloendopeptidase activity serine-type endopeptidase activity protein binding collagen binding metallopeptidase activity zinc ion binding identical protein binding fibronectin binding peptidase activity hydrolase activity protein complex binding metal ion binding
Process(es)
skeletal system development ossification positive regulation of protein phosphorylation positive regulation of leukocyte migration proteolysis response to oxidative stress embryo implantation transformation of host cell by virus extracellular matrix organization collagen catabolic process positive regulation of synaptic plasticity response to drug positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of DNA binding positive regulation of epidermal growth factor receptor signaling pathway positive regulation of angiogenesis negative regulation of fibroblast proliferation tissue remodeling leukocyte migration protein oligomerization positive regulation of keratinocyte migration cellular response to cell-matrix adhesion positive regulation of release of cytochrome c from mitochondria positive regulation of receptor binding negative regulation of intrinsic apoptotic signaling pathway negative regulation of cation channel activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway extracellular matrix disassembly macrophage differentiation endodermal cell differentiation ephrin receptor signaling pathway positive regulation of vascular smooth muscle cell proliferation
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