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Invitrogen
MMP9 Recombinant Rabbit Monoclonal Antibody (213)
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Product Details
MA5-31061
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
213
Immunogen
Recombinant Rat MMP9/MMP-9/CLG4B Protein (Met1-Pro708)
Conjugate
Form
Liquid
Concentration
0.79 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2786716
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Rat MMP9/MMP-9/CLG4B.
Target Information
MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase, a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins. MMP9 is secreted as a 92kDa zymogen and cleavage of pro-MMP9 results in the active enzyme with a molecular weight of 82kDa. MMP9 has a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells, and is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis. MMP9 is supplied by bone marrow-derived cells and contributes to skin carcinogenesis. Further, MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Studies have shown that elevated MMP9 is associated with progression of idiopathic atrial fibrillation and aortic aneurysm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 92 kDa gelatinase; 92 kDa type IV collagenase; 92-kDa type IV collagenase; Gelatinase B; Gelatinase-B; GELB; matrix metallo protease; matrix metalloproteinase 9 (gelatinase B 92-kDa type IV collagenase); matrix metalloproteinase 9 (gelatinase B, 92-kDa type IV collagenase); Matrix metalloproteinase-9; Matrix metalloproteinase9; MMP; MMP-9; MMPs
Gene Aliases: Mmp9
UniProt ID: (Rat) P50282
Entrez Gene ID: (Rat) 81687
skeletal system development
ossification
response to hypoxia
kidney development
positive regulation of leukocyte migration
proteolysis
response to oxidative stress
embryo implantation
parturition
aging
response to nutrient
response to radiation
response to heat
response to mechanical stimulus
response to high light intensity
response to organic substance
response to organic cyclic compound
transformation of host cell by virus
extracellular matrix organization
collagen catabolic process
positive regulation of synaptic plasticity
response to estradiol
response to lipopolysaccharide
response to retinoic acid
response to vitamin A
response to tumor necrosis factor
response to nicotine
endodermal cell differentiation
response to drug
positive regulation of apoptotic process
response to ethanol
positive regulation of angiogenesis
negative regulation of fibroblast proliferation
tissue remodeling
leukocyte migration
protein oligomerization
positive regulation of keratinocyte migration
response to hyperoxia
cellular response to lipopolysaccharide
cellular response to iron(III) ion
cellular response to cytokine stimulus
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to low-density lipoprotein particle stimulus
cellular response to cell-matrix adhesion
positive regulation of receptor binding
negative regulation of cation channel activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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