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Product Details
BS-8671R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human MMS 19, amino acids 851-950.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hMMS19; homolog of yeast MMS19; incisor protein; MET18 homolog; MMS19 cytosolic iron-sulfur assembly component; MMS19 nucleotide excision repair homolog; MMS19 nucleotide excision repair protein homolog; MMS19 nucleotide excision repair-like; MMS19-like (MET18 homolog, S. cerevisiae); MMS19-like protein
Gene Aliases: 2410001K24Rik; 2610042O15Rik; AI316855; C79368; C86341; hMMS19; MET18; MMS19; MMS19L
UniProt ID: (Human) Q96T76, (Mouse) Q9D071
Entrez Gene ID: (Human) 64210, (Rat) 171124, (Mouse) 72199
DNA metabolic process
DNA repair
cellular response to DNA damage stimulus
chromosome segregation
iron-sulfur cluster assembly
positive regulation of transcription, DNA-templated
transcription, DNA-templated
regulation of transcription, DNA-templated
phosphorelay signal transduction system
nucleotide-excision repair
response to hormone
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