Proteintech

MOV10 Polyclonal Antibody

MOV10 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

MOV10 Antibody (10370-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 10370-1-AP (MOV10 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IGG.

MOV10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MOV10 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10370-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 20 publications 20 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 4 publications 4 publications

RNA Immunoprecipitation (RIP)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MOV10 Fusion Protein Ag0384 (869-1004 aa encoded by BC002548)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.55 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QGQERSVIL ISTVRSSQSF VQLDLDFNLG FLKNPKRFNV AVTRAKALLI IVGNPLLLGH DPDWKVFLEF CKENGGYTGC PFPAKLDLQQ GQNLLQGLSK LSPSTSGPHS HDYLPQEREG EGGLSLQVEP EWRNEL (869-1004 aa encoded by BC002548 )

Target Information

5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs (PubMed:24726324). Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:16289642, PubMed:17507929, PubMed:22791714). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (PubMed:25464849). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1 (PubMed:30122351, PubMed:23093941). Facilitates LINE-1 uridylation by TUT4 and TUT7 (PubMed:30122351). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol. May function as a messenger ribonucleoprotein (mRNP) clearance factor (PubMed:24726324). Exhibits antiviral activity against dengue virus (DENV) (PubMed:27974568). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Atlas of interactions between SARS-CoV-2 macromolecules and host proteins.

Cell insight

Li G,Tang Z,Fan W,Wang X,Huang L,Jia Y,Wang M,Hu Z,Zhou Y

Wed Feb 01 00:00:00 UTC 2023

Atlas of interactions between SARS-CoV-2 macromolecules and host proteins.

Cell insight

Li G,Tang Z,Fan W,Wang X,Huang L,Jia Y,Wang M,Hu Z,Zhou Y

Wed Feb 01 00:00:00 UTC 2023

Sequestration of LINE-1 in cytosolic aggregates by MOV10 restricts retrotransposition.

EMBO reports

Arora R,Bodak M,Penouty L,Hackman C,Ciaudo C

Mon Sep 05 00:00:00 UTC 2022

Sequestration of LINE-1 in cytosolic aggregates by MOV10 restricts retrotransposition.

EMBO reports

Arora R,Bodak M,Penouty L,Hackman C,Ciaudo C

Mon Sep 05 00:00:00 UTC 2022

Proximity-based labeling reveals DNA damage-induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome.

The Journal of biological chemistry

Johnson MA,Nuckols TA,Merino P,Bagchi P,Nandy S,Root J,Taylor G,Seyfried NT,Kukar T

Mon Aug 01 00:00:00 UTC 2022

Proximity-based labeling reveals DNA damage-induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome.

The Journal of biological chemistry

Johnson MA,Nuckols TA,Merino P,Bagchi P,Nandy S,Root J,Taylor G,Seyfried NT,Kukar T

Mon Aug 01 00:00:00 UTC 2022

The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation.

Nature communications

Duszczyk MM,Wischnewski H,Kazeeva T,Arora R,Loughlin FE,von Schroetter C,Pradère U,Hall J,Ciaudo C,Allain FH

Thu Oct 06 00:00:00 UTC 2022

A male germ-cell-specific ribosome controls male fertility.

Nature

Li H,Huo Y,He X,Yao L,Zhang H,Cui Y,Xiao H,Xie W,Zhang D,Wang Y,Zhang S,Tu H,Cheng Y,Guo Y,Cao X,Zhu Y,Jiang T,Guo X,Qin Y,Sha J

Thu Dec 01 00:00:00 UTC 2022

The association of MOV10 polymorphism and expression levels with preeclampsia in the Chinese Han population.

Molecular genetics & genomic medicine

Tang Q,Wang L,Cai R,Zhang L,Zhang X,Liu X,Liu S

Fri Jan 01 00:00:00 UTC 2021

Multivalent Proteins Rapidly and Reversibly Phase-Separate upon Osmotic Cell Volume Change.

Molecular cell

Jalihal AP,Pitchiaya S,Xiao L,Bawa P,Jiang X,Bedi K,Parolia A,Cieslik M,Ljungman M,Chinnaiyan AM,Walter NG

Thu Sep 17 00:00:00 UTC 2020

Host restriction of emerging high-pathogenic bunyaviruses via MOV10 by targeting viral nucleoprotein and blocking ribonucleoprotein assembly.

PLoS pathogens

Mo Q,Xu Z,Deng F,Wang H,Ning YJ

Tue Dec 01 00:00:00 UTC 2020

MOV10 sequesters the RNP of influenza A virus in the cytoplasm and is antagonized by viral NS1 protein.

The Biochemical journal

Li J,Hu S,Xu F,Mei S,Liu X,Yin L,Zhao F,Zhao X,Sun H,Xiong Z,Zhang D,Cen S,Wang J,Liang C,Guo F

Tue Feb 05 00:00:00 UTC 2019

MOV10 sequesters the RNP of influenza A virus in the cytoplasm and is antagonized by viral NS1 protein.

The Biochemical journal

Li J,Hu S,Xu F,Mei S,Liu X,Yin L,Zhao F,Zhao X,Sun H,Xiong Z,Zhang D,Cen S,Wang J,Liang C,Guo F

Tue Feb 05 00:00:00 UTC 2019

MOV10 sequesters the RNP of influenza A virus in the cytoplasm and is antagonized by viral NS1 protein.

The Biochemical journal

Li J,Hu S,Xu F,Mei S,Liu X,Yin L,Zhao F,Zhao X,Sun H,Xiong Z,Zhang D,Cen S,Wang J,Liang C,Guo F

Tue Feb 05 00:00:00 UTC 2019

MOV10 sequesters the RNP of influenza A virus in the cytoplasm and is antagonized by viral NS1 protein.

The Biochemical journal

Li J,Hu S,Xu F,Mei S,Liu X,Yin L,Zhao F,Zhao X,Sun H,Xiong Z,Zhang D,Cen S,Wang J,Liang C,Guo F

Tue Feb 05 00:00:00 UTC 2019

MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change.

Journal of experimental & clinical cancer research : CR

He Q,Zhao L,Liu X,Zheng J,Liu Y,Liu L,Ma J,Cai H,Li Z,Xue Y

Tue Jan 08 00:00:00 UTC 2019

MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change.

Journal of experimental & clinical cancer research : CR

He Q,Zhao L,Liu X,Zheng J,Liu Y,Liu L,Ma J,Cai H,Li Z,Xue Y

Tue Jan 08 00:00:00 UTC 2019

Biological and RNA regulatory function of MOV10 in mammalian germ cells.

BMC biology

Fu K,Tian S,Tan H,Wang C,Wang H,Wang M,Wang Y,Chen Z,Wang Y,Yue Q,Xu Q,Zhang S,Li H,Xie J,Lin M,Luo M,Chen F,Ye L,Zheng K

Tue May 14 00:00:00 UTC 2019

Biological and RNA regulatory function of MOV10 in mammalian germ cells.

BMC biology

Fu K,Tian S,Tan H,Wang C,Wang H,Wang M,Wang Y,Chen Z,Wang Y,Yue Q,Xu Q,Zhang S,Li H,Xie J,Lin M,Luo M,Chen F,Ye L,Zheng K

Tue May 14 00:00:00 UTC 2019

Biological and RNA regulatory function of MOV10 in mammalian germ cells.

BMC biology

Fu K,Tian S,Tan H,Wang C,Wang H,Wang M,Wang Y,Chen Z,Wang Y,Yue Q,Xu Q,Zhang S,Li H,Xie J,Lin M,Luo M,Chen F,Ye L,Zheng K

Tue May 14 00:00:00 UTC 2019

Stress granules and RNA processing bodies are novel autoantibody targets in systemic sclerosis.

Arthritis research & therapy

Johnson ME,Grassetti AV,Taroni JN,Lyons SM,Schweppe D,Gordon JK,Spiera RF,Lafyatis R,Anderson PJ,Gerber SA,Whitfield ML

Fri Jan 22 00:00:00 UTC 2016

Stress granules and RNA processing bodies are novel autoantibody targets in systemic sclerosis.

Arthritis research & therapy

Johnson ME,Grassetti AV,Taroni JN,Lyons SM,Schweppe D,Gordon JK,Spiera RF,Lafyatis R,Anderson PJ,Gerber SA,Whitfield ML

Fri Jan 22 00:00:00 UTC 2016

The role of Moloney leukemia virus 10 in hepatitis B virus expression in hepatoma cells.

Virus research

Ma YX,Li D,Fu LJ,Fu BQ,Chen SJ,Xu WZ,Teng X,Song ZW,Gu HX

Mon Feb 02 00:00:00 UTC 2015

The role of Moloney leukemia virus 10 in hepatitis B virus expression in hepatoma cells.

Virus research

Ma YX,Li D,Fu LJ,Fu BQ,Chen SJ,Xu WZ,Teng X,Song ZW,Gu HX

Mon Feb 02 00:00:00 UTC 2015

ARF1 regulates adhesion of MDA-MB-231 invasive breast cancer cells through formation of focal adhesions.

Cellular signalling

Schlienger S,Ramirez RA,Claing A

Sun Mar 01 00:00:00 UTC 2015

ARF1 regulates adhesion of MDA-MB-231 invasive breast cancer cells through formation of focal adhesions.

Cellular signalling

Schlienger S,Ramirez RA,Claing A

Sun Mar 01 00:00:00 UTC 2015

MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.

Molecular cell

Gregersen LH,Schueler M,Munschauer M,Mastrobuoni G,Chen W,Kempa S,Dieterich C,Landthaler M

Thu May 22 00:00:00 UTC 2014

MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.

Molecular cell

Gregersen LH,Schueler M,Munschauer M,Mastrobuoni G,Chen W,Kempa S,Dieterich C,Landthaler M

Thu May 22 00:00:00 UTC 2014

Moloney leukemia virus type 10 inhibits reverse transcription and retrotransposition of intracisternal a particles.

Journal of virology

Lu C,Luo Z,Jäger S,Krogan NJ,Peterlin BM

Mon Oct 01 00:00:00 UTC 2012

Moloney leukemia virus type 10 inhibits reverse transcription and retrotransposition of intracisternal a particles.

Journal of virology

Lu C,Luo Z,Jäger S,Krogan NJ,Peterlin BM

Mon Oct 01 00:00:00 UTC 2012

Moloney leukemia virus type 10 inhibits reverse transcription and retrotransposition of intracisternal a particles.

Journal of virology

Lu C,Luo Z,Jäger S,Krogan NJ,Peterlin BM

Mon Oct 01 00:00:00 UTC 2012

Moloney leukemia virus type 10 inhibits reverse transcription and retrotransposition of intracisternal a particles.

Journal of virology

Lu C,Luo Z,Jäger S,Krogan NJ,Peterlin BM

Mon Oct 01 00:00:00 UTC 2012

Endogenous MOV10 inhibits the retrotransposition of endogenous retroelements but not the replication of exogenous retroviruses.

Retrovirology

Arjan-Odedra S,Swanson CM,Sherer NM,Wolinsky SM,Malim MH

Fri Jun 22 00:00:00 UTC 2012

Endogenous MOV10 inhibits the retrotransposition of endogenous retroelements but not the replication of exogenous retroviruses.

Retrovirology

Arjan-Odedra S,Swanson CM,Sherer NM,Wolinsky SM,Malim MH

Fri Jun 22 00:00:00 UTC 2012

Identification of molecular determinants from Moloney leukemia virus 10 homolog (MOV10) protein for virion packaging and anti-HIV-1 activity.

The Journal of biological chemistry

Abudu A,Wang X,Dang Y,Zhou T,Xiang SH,Zheng YH

Fri Jan 06 00:00:00 UTC 2012

Identification of molecular determinants from Moloney leukemia virus 10 homolog (MOV10) protein for virion packaging and anti-HIV-1 activity.

The Journal of biological chemistry

Abudu A,Wang X,Dang Y,Zhou T,Xiang SH,Zheng YH

Fri Jan 06 00:00:00 UTC 2012

MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells.

PLoS genetics

Goodier JL,Cheung LE,Kazazian HH

Fri Mar 22 00:00:00 UTC 2013

MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells.

PLoS genetics

Goodier JL,Cheung LE,Kazazian HH

Fri Mar 22 00:00:00 UTC 2013

MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells.

PLoS genetics

Goodier JL,Cheung LE,Kazazian HH

Fri Mar 22 00:00:00 UTC 2013

MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells.

PLoS genetics

Goodier JL,Cheung LE,Kazazian HH

Fri Mar 22 00:00:00 UTC 2013

Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity.

PloS one

Furtak V,Mulky A,Rawlings SA,Kozhaya L,Lee K,Kewalramani VN,Unutmaz D

Fri Feb 05 00:00:00 UTC 2010

Perturbation of the P-body component Mov10 inhibits HIV-1 infectivity.

PloS one

Furtak V,Mulky A,Rawlings SA,Kozhaya L,Lee K,Kewalramani VN,Unutmaz D

Fri Feb 05 00:00:00 UTC 2010

Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication.

The Journal of biological chemistry

Wang X,Han Y,Dang Y,Fu W,Zhou T,Ptak RG,Zheng YH

Fri May 07 00:00:00 UTC 2010

Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication.

The Journal of biological chemistry

Wang X,Han Y,Dang Y,Fu W,Zhou T,Ptak RG,Zheng YH

Fri May 07 00:00:00 UTC 2010

A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation.

Neuron

Banerjee S,Neveu P,Kosik KS

Thu Dec 24 00:00:00 UTC 2009

A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation.

Neuron

Banerjee S,Neveu P,Kosik KS

Thu Dec 24 00:00:00 UTC 2009

Combined proteomic-RNAi screen for host factors involved in human hepatitis delta virus replication.

RNA (New York, N.Y.)

Cao D,Haussecker D,Huang Y,Kay MA

Sun Nov 01 00:00:00 UTC 2009

Combined proteomic-RNAi screen for host factors involved in human hepatitis delta virus replication.

RNA (New York, N.Y.)

Cao D,Haussecker D,Huang Y,Kay MA

Sun Nov 01 00:00:00 UTC 2009

Capped small RNAs and MOV10 in human hepatitis delta virus replication.

Nature structural & molecular biology

Haussecker D,Cao D,Huang Y,Parameswaran P,Fire AZ,Kay MA

Tue Jul 01 00:00:00 UTC 2008

Capped small RNAs and MOV10 in human hepatitis delta virus replication.

Nature structural & molecular biology

Haussecker D,Cao D,Huang Y,Parameswaran P,Fire AZ,Kay MA

Tue Jul 01 00:00:00 UTC 2008

Capped small RNAs and MOV10 in human hepatitis delta virus replication.

Nature structural & molecular biology

Haussecker D,Cao D,Huang Y,Parameswaran P,Fire AZ,Kay MA

Tue Jul 01 00:00:00 UTC 2008

Capped small RNAs and MOV10 in human hepatitis delta virus replication.

Nature structural & molecular biology

Haussecker D,Cao D,Huang Y,Parameswaran P,Fire AZ,Kay MA

Tue Jul 01 00:00:00 UTC 2008

APOBEC3G and APOBEC3F require an endogenous cofactor to block HIV-1 replication.

PLoS pathogens

Han Y,Wang X,Dang Y,Zheng YH

Fri Jul 04 00:00:00 UTC 2008

APOBEC3G and APOBEC3F require an endogenous cofactor to block HIV-1 replication.

PLoS pathogens

Han Y,Wang X,Dang Y,Zheng YH

Fri Jul 04 00:00:00 UTC 2008

Bioinformatics

Protein Aliases: Armitage homolog; capping protein (actin filament) muscle Z-line, alpha 1; functional spliceosome-associated protein 113; Helicase MOV-10; Moloney leukemia virus 10 protein; Mov10, Moloney leukemia virus 10; Mov10, Moloney leukemia virus 10, homolog; Putative helicase MOV-10

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Gene Aliases: C77703; Capza1; fSAP113; Gb110; KIAA1631; Mov-10; MOV10

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UniProt ID: (Human) Q9HCE1, (Mouse) P23249

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Entrez Gene ID: (Human) 4343, (Rat) 310756, (Mouse) 17454

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Function(s)

helicase activity protein binding ATP binding poly(A) RNA binding molecular_function nucleotide binding RNA binding hydrolase activity

Process(es)

biological_process mRNA cleavage involved in gene silencing by miRNA transcription, DNA-templated regulation of transcription, DNA-templated Wnt signaling pathway, calcium modulating pathway gene silencing by miRNA phosphatidylinositol-mediated signaling gene silencing by RNA

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MOV10 Polyclonal Antibody

MOV10 Antibody (10370-1-AP) in ICC/IF

Product Details

10370-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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