Invitrogen

MOZ Polyclonal Antibody

MOZ Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MOZ Antibody (PA5-103467) in IHC (P)

Immunohistochemistry analysis of MOZ in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with MOZ polyclonal antibody (Product # PA5-103467) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.

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Product Details

PA5-103467

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human KAT6A(Accession Q92794), corresponding to amino acid residues K198-L248.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2852803

Product Specific Information

Antibody detects endogenous levels of total MYST3.

Target Information

Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A druggable copper-signalling pathway that drives inflammation.

Nature

Solier S,Müller S,Cañeque T,Versini A,Mansart A,Sindikubwabo F,Baron L,Emam L,Gestraud P,Pantoș GD,Gandon V,Gaillet C,Wu TD,Dingli F,Loew D,Baulande S,Durand S,Sencio V,Robil C,Trottein F,Péricat D,Näser E,Cougoule C,Meunier E,Bègue AL,Salmon H,Manel N,Puisieux A,Watson S,Dawson MA,Servant N,Kroemer G,Annane D,Rodriguez R

PA5-103467 was used in Western Blotting to highlight the central role of copper as a regulator of cell plasticity and unveils a therapeutic strategy based on metabolic reprogramming and the control of epigenetic cell states.

Mon May 01 00:00:00 UTC 2023

The Expression of Histone Acetyltransferase KAT6A in Non-small Cell Lung Cancer.

Anticancer research

Partynska A,Piotrowska A,Pawelczyk K,Rzechonek A,Ratajczak-Wielgomas K,Podhorska-Okolow M,Dziegiel P

PA5-103467 was used in Immunohistochemistry (Paraffin), Western Blot to demonstrate elevated expression of KAT6A in lung cancer cell lines in comparison to normal lung fibroblasts, suggesting its oncogenic role.

Thu Dec 01 00:00:00 UTC 2022

Bioinformatics

Protein Aliases: Histone acetyltransferase KAT6A; histone acetyltransferase MYST3; K(lysine) acetyltransferase 6A; Monocytic leukemia zinc finger homolog; Monocytic leukemia zinc finger protein; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYST histone acetyltransferase (monocytic leukemia) 3; MYST-3; runt-related transcription factor binding protein 2; Runt-related transcription factor-binding protein 2; Zinc finger protein 220

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Gene Aliases: 1500036M03; 9930021N24Rik; KAT6A; MOZ; MRD32; MYST-3; MYST3; RUNXBP2; ZC2HC6A; Zfp220; ZNF220

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UniProt ID: (Human) Q92794, (Rat) Q5TKR9

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Entrez Gene ID: (Human) 7994, (Mouse) 244349, (Rat) 306571

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Function(s)

DNA binding transcription coactivator activity histone acetyltransferase activity protein binding transcription factor binding zinc ion binding acetyltransferase activity chromatin binding transferase activity transferase activity, transferring acyl groups transferase activity, transferring acyl groups other than amino-acyl groups metal ion binding

Process(es)

heart morphogenesis nucleosome assembly transcription, DNA-templated regulation of transcription, DNA-templated protein acetylation positive regulation of gene expression chromatin modification histone acetylation myeloid cell differentiation somatic stem cell population maintenance embryonic hemopoiesis aorta morphogenesis negative regulation of sequence-specific DNA binding transcription factor activity histone H3 acetylation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated face morphogenesis cellular senescence DNA packaging regulation of signal transduction by p53 class mediator

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MOZ Polyclonal Antibody

MOZ Antibody (PA5-103467) in IHC (P)

Product Details

PA5-103467

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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