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MPC2 Polyclonal Antibody

MPC2 Antibody in Immunocytochemistry (ICC/IF)

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MPC2 Antibody (20049-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HepG2 cells using 20049-1-AP (MPC2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

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Product Details

20049-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.41 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody is specific to BRP44.

Target Information

Mediates the uptake of pyruvate into mitochondria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.

Frontiers in aging neuroscience

Allen SP,Al Sultan A,Kabucho Kibirige E,Tonkiss E,Hamer KJ,Castelli LM,Lin YH,Roscoe S,Stefanidis N,Mead RJ,Highley JR,Cooper-Knock J,Hautbergue GM,Heath PR,Kirby J,Shaw PJ

Wed Jun 26 00:00:00 UTC 2024

Systemic Proteome Phenotypes Reveal Defective Metabolic Flexibility in Mecp2 Mutants.

bioRxiv : the preprint server for biology

Zlatic SA,Werner E,Surapaneni V,Lee CE,Gokhale A,Singleton K,Duong D,Crocker A,Gentile K,Middleton F,Dalloul JM,Liu WL,Patgiri A,Tarquinio D,Carpenter R,Faundez V

Fri Sep 01 00:00:00 UTC 2023

Downregulation of mitochondrial pyruvate carrier 2 aggravates neuronal injury in the cortex following cerebral ischemia in rat.

Brain research bulletin

Wang Y,Liu Y,Yuan Y,Zhang Y,Luo Y,Han S,Yan Y,Wang Z,Liu X,Zhao L

Fri Jul 01 00:00:00 UTC 2022

Downregulation of mitochondrial pyruvate carrier 2 aggravates neuronal injury in the cortex following cerebral ischemia in rat.

Brain research bulletin

Wang Y,Liu Y,Yuan Y,Zhang Y,Luo Y,Han S,Yan Y,Wang Z,Liu X,Zhao L

Fri Jul 01 00:00:00 UTC 2022

Mitochondrial pyruvate carrier blockade results in decreased osteoclastogenesis and bone resorption via regulating mitochondrial energy production.

The Journal of biological chemistry

Guo Q,Zhao H,Cheng H,Kang H,Dong Y,Peng R,Zhu M,Fang Z,Li F

Fri Mar 04 00:00:00 UTC 2022

Abnormal early folliculogenesis due to impeded pyruvate metabolism in mouse oocytes†.

Biology of reproduction

Tanaka K,Hayashi Y,Takehara A,Ito-Matsuoka Y,Tachibana M,Yaegashi N,Matsui Y

Fri Jul 02 00:00:00 UTC 2021

Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos.

Current biology : CB

Gomkale R,Cruz-Zaragoza LD,Suppanz I,Guiard B,Montoya J,Callegari S,Pacheu-Grau D,Warscheid B,Rehling P

Mon Mar 23 00:00:00 UTC 2020

Mitochondrial pyruvate carrier 2 mediates mitochondrial dysfunction and apoptosis in high glucose-treated podocytes.

Life sciences

Feng J,Ma Y,Chen Z,Hu J,Yang Q,Ding G

Fri Nov 15 00:00:00 UTC 2019

Function of mitochondrial pyruvate carriers in hepatocellular carcinoma patients.

Oncology letters

Ma X,Cui Y,Zhou H,Li Q

Fri Jun 01 00:00:00 UTC 2018

Function of mitochondrial pyruvate carriers in hepatocellular carcinoma patients.

Oncology letters

Ma X,Cui Y,Zhou H,Li Q

Fri Jun 01 00:00:00 UTC 2018

3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants.

Molecular cancer

Konstantakou EG,Voutsinas GE,Velentzas AD,Basogianni AS,Paronis E,Balafas E,Kostomitsopoulos N,Syrigos KN,Anastasiadou E,Stravopodis DJ

Wed Jul 22 00:00:00 UTC 2015

3-BrPA eliminates human bladder cancer cells with highly oncogenic signatures via engagement of specific death programs and perturbation of multiple signaling and metabolic determinants.

Molecular cancer

Konstantakou EG,Voutsinas GE,Velentzas AD,Basogianni AS,Paronis E,Balafas E,Kostomitsopoulos N,Syrigos KN,Anastasiadou E,Stravopodis DJ

Wed Jul 22 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Brain protein 44; Mitochondrial pyruvate carrier 2; Protein 0-44

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Gene Aliases: 0610006C01Rik; 2010002I07Rik; 2610205H19Rik; AA108335; BRP44; ESTM43; MPC2; RGD1563422

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UniProt ID: (Human) O95563, (Rat) P38718, (Mouse) Q9D023

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Entrez Gene ID: (Human) 25874, (Rat) 100359982, (Mouse) 70456

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Function(s)

pyruvate transmembrane transporter activity

Process(es)

pyruvate metabolic process mitochondrial pyruvate transport pyruvate transmembrane transport transport positive regulation of insulin secretion involved in cellular response to glucose stimulus mitochondrial acetyl-CoA biosynthetic process from pyruvate mitochondrial pyruvate transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MPC2 Polyclonal Antibody

MPC2 Antibody (20049-1-AP) in ICC/IF

Product Details

20049-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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