Proteintech

MPP5 Polyclonal Antibody

MPP5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 6

MPP5 Antibody (17710-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using (Product # 17710-1-AP) (MPP5 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

MPP5 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17710-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

Assay-dependent

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

Immunocytochemistry (ICC/IF)

View 14 publications 14 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MPP5 Fusion Protein Ag12010 (1-341 aa encoded by BC095485)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MTTSHMNGH VTEESDSEVK NVDLASPEEH QKHREMAVDC PGDLGTRMMP IRRSAQLERI RQQQEDMRRR REEEGKKQEL DLNSSMRLKK LAQIPPKTGI DNPMFDTEEG IVLESPHYAV KILEIEDLFS SLKHIQHTLV DSQSQEDISL LLQLVQNKDF QNAFKIHNAI TVHMNKASPP FPLISNAQDL AQEVQTVLKP VHHKEGQELT ALLNTPHIQA LLLAHDKVAE QEMQLEPITD ERVYESIGQY GGETVKIVRI EKARDIPLGA TVRNEMDSVI ISRIVKGGAA EKSGLLHEGD EVLEINGIEI RGKDVNEVFD LLSDMHGTLT FVLIPSQQIK PP (1-341 aa encoded by BC095485)

Target Information

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasion.

Cancer gene therapy

Harms J,Lüttgenau SM,Emming C,Guske J,Weber K,Wagner T,Schowe L,Nedvetsky P,Krahn MP

Wed Mar 01 00:00:00 UTC 2023

Pals1 functions in redundancy with SMAP1 to inhibit Arf6 in order to prevent Rac1-dependent colorectal cancer cell migration and invasion.

Cancer gene therapy

Harms J,Lüttgenau SM,Emming C,Guske J,Weber K,Wagner T,Schowe L,Nedvetsky P,Krahn MP

Wed Mar 01 00:00:00 UTC 2023

An entosis-like process induces mitotic disruption in Pals1 microcephaly pathogenesis.

Nature communications

Sterling NA,Park JY,Park R,Cho SH,Kim S

Thu Jan 05 00:00:00 UTC 2023

Multicellular rosettes link mesenchymal-epithelial transition to radial intercalation in the mouse axial mesoderm.

Developmental cell

Gredler ML,Zallen JA

Mon Jun 05 00:00:00 UTC 2023

The evolutionary history of the polyQ tract in huntingtin sheds light on its functional pro-neural activities.

Cell death and differentiation

Iennaco R,Formenti G,Trovesi C,Rossi RL,Zuccato C,Lischetti T,Bocchi VD,Scolz A,Martínez-Labarga C,Rickards O,Pacifico M,Crottini A,Møller AP,Chen RZ,Vogt TF,Pavesi G,Horner DS,Saino N,Cattaneo E

Tue Feb 01 00:00:00 UTC 2022

RAB6 and dynein drive post-Golgi apical transport to prevent neuronal progenitor delamination.

EMBO reports

Brault JB,Bardin S,Lampic M,Carpentieri JA,Coquand L,Penisson M,Lachuer H,Victoria GS,Baloul S,El Marjou F,Boncompain G,Miserey-Lenkei S,Belvindrah R,Fraisier V,Francis F,Perez F,Goud B,Baffet AD

Thu Oct 06 00:00:00 UTC 2022

CD13 orients the apical-basal polarity axis necessary for lumen formation.

Nature communications

Wang LT,Rajah A,Brown CM,McCaffrey L

Wed Aug 04 00:00:00 UTC 2021

CD13 orients the apical-basal polarity axis necessary for lumen formation.

Nature communications

Wang LT,Rajah A,Brown CM,McCaffrey L

Wed Aug 04 00:00:00 UTC 2021

Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier.

Journal of the American Society of Nephrology : JASN

Möller-Kerutt A,Rodriguez-Gatica JE,Wacker K,Bhatia R,Siebrasse JP,Boon N,Van Marck V,Boor P,Kubitscheck U,Wijnholds J,Pavenstädt H,Weide T

Mon May 03 00:00:00 UTC 2021

Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier.

Journal of the American Society of Nephrology : JASN

Möller-Kerutt A,Rodriguez-Gatica JE,Wacker K,Bhatia R,Siebrasse JP,Boon N,Van Marck V,Boor P,Kubitscheck U,Wijnholds J,Pavenstädt H,Weide T

Mon May 03 00:00:00 UTC 2021

Yap/Taz are required for establishing the cerebellar radial glia scaffold and proper foliation.

Developmental biology

Hughes LJ,Park R,Lee MJ,Terry BK,Lee DJ,Kim H,Cho SH,Kim S

Wed Jan 01 00:00:00 UTC 2020

Yap/Taz are required for establishing the cerebellar radial glia scaffold and proper foliation.

Developmental biology

Hughes LJ,Park R,Lee MJ,Terry BK,Lee DJ,Kim H,Cho SH,Kim S

Wed Jan 01 00:00:00 UTC 2020

Choroid plexus epithelial cells express the adhesion protein P-cadherin at cell-cell contacts and syntaxin-4 in the luminal membrane domain.

American journal of physiology. Cell physiology

Christensen IB,Mogensen EN,Damkier HH,Praetorius J

Tue May 01 00:00:00 UTC 2018

Mosaic Analysis with Double Markers Reveals Distinct Sequential Functions of Lgl1 in Neural Stem Cells.

Neuron

Beattie R,Postiglione MP,Burnett LE,Laukoter S,Streicher C,Pauler FM,Xiao G,Klezovitch O,Vasioukhin V,Ghashghaei TH,Hippenmeyer S

Wed May 03 00:00:00 UTC 2017

Mosaic Analysis with Double Markers Reveals Distinct Sequential Functions of Lgl1 in Neural Stem Cells.

Neuron

Beattie R,Postiglione MP,Burnett LE,Laukoter S,Streicher C,Pauler FM,Xiao G,Klezovitch O,Vasioukhin V,Ghashghaei TH,Hippenmeyer S

Wed May 03 00:00:00 UTC 2017

BBSome function is required for both the morphogenesis and maintenance of the photoreceptor outer segment.

PLoS genetics

Hsu Y,Garrison JE,Kim G,Schmitz AR,Searby CC,Zhang Q,Datta P,Nishimura DY,Seo S,Sheffield VC

Sun Oct 01 00:00:00 UTC 2017

BBSome function is required for both the morphogenesis and maintenance of the photoreceptor outer segment.

PLoS genetics

Hsu Y,Garrison JE,Kim G,Schmitz AR,Searby CC,Zhang Q,Datta P,Nishimura DY,Seo S,Sheffield VC

Sun Oct 01 00:00:00 UTC 2017

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.

Neuron

Jayaraman D,Kodani A,Gonzalez DM,Mancias JD,Mochida GH,Vagnoni C,Johnson J,Krogan N,Harper JW,Reiter JF,Yu TW,Bae BI,Walsh CA

Wed Nov 23 00:00:00 UTC 2016

Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate.

Neuron

Jayaraman D,Kodani A,Gonzalez DM,Mancias JD,Mochida GH,Vagnoni C,Johnson J,Krogan N,Harper JW,Reiter JF,Yu TW,Bae BI,Walsh CA

Wed Nov 23 00:00:00 UTC 2016

Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon.

Neuroscience research

Dudok JJ,Murtaza M,Henrique Alves C,Rashbass P,Wijnholds J

Fri Jul 01 00:00:00 UTC 2016

Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon.

Neuroscience research

Dudok JJ,Murtaza M,Henrique Alves C,Rashbass P,Wijnholds J

Fri Jul 01 00:00:00 UTC 2016

Applying a new quantitative global breast MRI feature analysis scheme to assess tumor response to chemotherapy.

Journal of magnetic resonance imaging : JMRI

Aghaei F,Tan M,Hollingsworth AB,Zheng B

Tue Nov 01 00:00:00 UTC 2016

MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Müller cells.

Glia

Dudok JJ,Sanz AS,Lundvig DM,Sothilingam V,Garcia Garrido M,Klooster J,Seeliger MW,Wijnholds J

Tue Oct 01 00:00:00 UTC 2013

MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Müller cells.

Glia

Dudok JJ,Sanz AS,Lundvig DM,Sothilingam V,Garcia Garrido M,Klooster J,Seeliger MW,Wijnholds J

Tue Oct 01 00:00:00 UTC 2013

Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kanda A,Noda K,Yuki K,Ozawa Y,Furukawa T,Ichihara A,Ishida S

Wed Dec 04 00:00:00 UTC 2013

Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Kanda A,Noda K,Yuki K,Ozawa Y,Furukawa T,Ichihara A,Ishida S

Wed Dec 04 00:00:00 UTC 2013

MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Dudok JJ,Sanz AS,Lundvig DM,Wijnholds J

Wed May 08 00:00:00 UTC 2013

MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Dudok JJ,Sanz AS,Lundvig DM,Wijnholds J

Wed May 08 00:00:00 UTC 2013

Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.

Human molecular genetics

Alves CH,Sanz AS,Park B,Pellissier LP,Tanimoto N,Beck SC,Huber G,Murtaza M,Richard F,Sridevi Gurubaran I,Garcia Garrido M,Levelt CN,Rashbass P,Le Bivic A,Seeliger MW,Wijnholds J

Tue Jan 01 00:00:00 UTC 2013

Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.

Human molecular genetics

Alves CH,Sanz AS,Park B,Pellissier LP,Tanimoto N,Beck SC,Huber G,Murtaza M,Richard F,Sridevi Gurubaran I,Garcia Garrido M,Levelt CN,Rashbass P,Le Bivic A,Seeliger MW,Wijnholds J

Tue Jan 01 00:00:00 UTC 2013

Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis.

PLoS genetics

Pellissier LP,Alves CH,Quinn PM,Vos RM,Tanimoto N,Lundvig DM,Dudok JJ,Hooibrink B,Richard F,Beck SC,Huber G,Sothilingam V,Garcia Garrido M,Le Bivic A,Seeliger MW,Wijnholds J

Wed Aug 20 00:00:00 UTC 2014

Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis.

PLoS genetics

Pellissier LP,Alves CH,Quinn PM,Vos RM,Tanimoto N,Lundvig DM,Dudok JJ,Hooibrink B,Richard F,Beck SC,Huber G,Sothilingam V,Garcia Garrido M,Le Bivic A,Seeliger MW,Wijnholds J

Wed Aug 20 00:00:00 UTC 2014

Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background.

PloS one

Alves CH,Bossers K,Vos RM,Essing AH,Swagemakers S,van der Spek PJ,Verhaagen J,Wijnholds J

Thu Jul 31 00:00:00 UTC 2014

Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background.

PloS one

Alves CH,Bossers K,Vos RM,Essing AH,Swagemakers S,van der Spek PJ,Verhaagen J,Wijnholds J

Thu Jul 31 00:00:00 UTC 2014

PALS1 is essential for retinal pigment epithelium structure and neural retina stratification.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Park B,Alves CH,Lundvig DM,Tanimoto N,Beck SC,Huber G,Richard F,Klooster J,Andlauer TF,Swindell EC,Jamrich M,Le Bivic A,Seeliger MW,Wijnholds J

Wed Nov 23 00:00:00 UTC 2011

PALS1 is essential for retinal pigment epithelium structure and neural retina stratification.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Park B,Alves CH,Lundvig DM,Tanimoto N,Beck SC,Huber G,Richard F,Klooster J,Andlauer TF,Swindell EC,Jamrich M,Le Bivic A,Seeliger MW,Wijnholds J

Wed Nov 23 00:00:00 UTC 2011

PALS1 is essential for retinal pigment epithelium structure and neural retina stratification.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Park B,Alves CH,Lundvig DM,Tanimoto N,Beck SC,Huber G,Richard F,Klooster J,Andlauer TF,Swindell EC,Jamrich M,Le Bivic A,Seeliger MW,Wijnholds J

Wed Nov 23 00:00:00 UTC 2011

PALS1 is essential for retinal pigment epithelium structure and neural retina stratification.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Park B,Alves CH,Lundvig DM,Tanimoto N,Beck SC,Huber G,Richard F,Klooster J,Andlauer TF,Swindell EC,Jamrich M,Le Bivic A,Seeliger MW,Wijnholds J

Wed Nov 23 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: FLJ12615; MAGUK p55 subfamily member 5; membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 5); Membrane protein, palmitoylated 5; membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); palmitoylated 5; protein associated with lin seven 1; Protein associated with Lin-7 1; Protein PALS1; stardust

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Gene Aliases: 3830420B02Rik; AI255216; AI644496; MPP5; PALS1

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UniProt ID: (Human) Q8N3R9, (Mouse) Q9JLB2, (Rat) B4F7E7

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Entrez Gene ID: (Human) 64398, (Mouse) 56217, (Rat) 314259

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Function(s)

protein binding protein domain specific binding guanylate kinase activity

Process(es)

morphogenesis of an epithelial sheet plasma membrane organization peripheral nervous system myelin maintenance myelin assembly protein localization to myelin sheath abaxonal region nucleotide phosphorylation establishment of protein localization to plasma membrane bicellular tight junction assembly establishment of epithelial cell polarity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MPP5 Polyclonal Antibody

MPP5 Antibody (17710-1-AP) in IHC (P)

Product Details

17710-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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