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FIGURE: 1 / 1
MRCK alpha Antibody (PA5-68391) in IHC (P)
Immunohistochemical analysis of MRCK alpha in paraffin-embedded Human liver cancer tissue using (left) MRCK alpha Polyclonal Antibody (Product # PA5-68391) at a 1:45 dilution and (right) is treated with synthetic peptide. (Original magnification: x200).
Product Details
PA5-68391
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human MRCK alpha.
Conjugate
Form
Liquid
Concentration
1.6 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2692236
Product Specific Information
Predicted to react with Mouse and Rat samples.
Target Information
CDC42BPA (MRCKA) is a serine/threonine kinase which functions in actin cytoskeleton assembly and organization. Three independent coiled-coil domains and the N-terminal region preceding the kinase domain are responsible for intermolecular interactions leading to MRCK alpha multimerization. The transautophosphorylation process is critical for regulation of MRCK alpha catalytic activities. Binding of phorbol esters to MRCK releases its autoinhibition, allowing N-terminal dimerization and subsequent kinase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC42 binding protein kinase alpha (DMPK-like); CDC42 binidng protein kinase beta; CDC42-binding protein kinase alpha; CDC42-binding protein kinase alpha (DMPK-like); CDC42BPA; cdc42bpa {ECO:0000250|UniProtKB:Q5VT25}; DKFZp686L1738; DKFZp686P1738; DMPK-like alpha; FLJ23347; MRCK alpha; myotonic dystrophy kinase-related CDC-42-binding kinase-alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha; myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; myotonic dystrophy protein kinase-like alpha; mytonic dystrophy kinase-related Cdc42-binding kinase; RP5-1087E8.4; ser-thr protein kinase PK428; Ser-Thr protein kinase related to the myotonic dystrophy protein kinase; Serine/threonine-protein kinase MRCK alpha
Gene Aliases: A930014J19Rik; CDC42BPA; DMPK-like; KIAA0451; MRCK; MRCKA; PK428
UniProt ID: (Human) Q5VT25, (Rat) O54874, (Mouse) Q3UU96
Entrez Gene ID: (Human) 8476, (Rat) 114116, (Mouse) 226751
microtubule cytoskeleton organization
protein phosphorylation
cytoskeleton organization
nuclear migration
cell migration
actomyosin structure organization
actin cytoskeleton reorganization
intracellular signal transduction
regulation of catalytic activity
regulation of small GTPase mediated signal transduction
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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