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Product Details
PA5-33944
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human MRGPRD.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551312
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%) Gibbon (89%) Marmoset (83%).
Target Information
May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i). Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beta-alanine receptor; G-protein coupled receptor TGR7; mas-related G protein-coupled MRGD; Mas-related G-protein coupled receptor member D; MAS-related GPR, member D
Gene Aliases: MRGD; MRGPRD; TGR7
UniProt ID: (Human) Q8TDS7
Entrez Gene ID: (Human) 116512
Performance Guarantee
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