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Product Details
MA1-35684
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
M5II-54
Immunogen
MRP5 aa 722-910
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
tissue culture supernatant with 0.7% BSA
Contains
0.1% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2219530
Product Specific Information
M5II-54 reacts with an internal epitope of MRP5, a 190-200 kD transmembrane protein that is closely related to the multidrug resistance protein MRP. M5II-54 was raised against a bacterial fusion protein of MRP5, containing amino acids 722-910 of the protein. M5I-1 does not cross-react with the human MDR1, MRP1, MRP2 or MRP3 gene products
Target Information
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC 33; ABCC 5; ATP-binding cassette sub-family C member 5; ATP-binding cassette, sub-family C (CFTR/MRP), member 5; canalicular multispecific organic anion transporter C; DKFZp686C1782; MOAT C; MOAT-C; MRP 5; Multi-specific organic anion transporter C; Multidrug resistance-associated protein 5; pABC 11; pABC11; SMRP
Gene Aliases: ABC33; ABCC5; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
UniProt ID: (Human) O15440
Entrez Gene ID: (Human) 10057
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