Proteintech

MRPL11 Polyclonal Antibody

MRPL11 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 21

MRPL11 Antibody (15543-1-AP) in ICC/IF

Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HepG2 cells using 15543-1-AP (MRPL11 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

MRPL11 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MRPL11 Antibody in Flow Cytometry (Flow)

MRPL11 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15543-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 10 publications 10 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MRPL11 Fusion Protein Ag7899 (1-192 aa encoded by BC005002)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSKLGRAAR GLRKPEVGGV IRAIVRAGLA MPGPPLGPVL GQRGVSINQF CKEFNERTKD IKEGIPLPTK ILVKPDRTFE IKIGQPTVSY FLKAAAGIEK GARQTGKEVA GLVTLKHVYE IARIKAQDEA FALQDVPLSS VVRSIIGSAR SLGIRVVKDL SSEELAAFQK ERAIFLAAQK EADLAAQEEA AKK (1-192 aa encoded by BC005002)

Target Information

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode different isoforms. Pseudogenes corresponding to this gene are found on chromosomes 5q and 12q.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Sucrose Gradient Analysis of Human Mitochondrial Ribosomes and RNA.

Methods in molecular biology (Clifton, N.J.)

Ng KY,Battersby BJ

Mon May 15 00:00:00 UTC 2023

MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.

iScience

Ji X,Chu L,Su D,Sun J,Song P,Sun S,Wang Y,Mu Q,Liu Y,Wan Q

Fri May 19 00:00:00 UTC 2023

MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.

iScience

Ji X,Chu L,Su D,Sun J,Song P,Sun S,Wang Y,Mu Q,Liu Y,Wan Q

Fri May 19 00:00:00 UTC 2023

Nonstop mRNAs generate a ground state of mitochondrial gene expression noise.

Science advances

Ng KY,Lutfullahoglu Bal G,Richter U,Safronov O,Paulin L,Dunn CD,Paavilainen VO,Richer J,Newman WG,Taylor RW,Battersby BJ

Wed Nov 16 00:00:00 UTC 2022

Translation of MT-ATP6 pathogenic variants reveals distinct regulatory consequences from the co-translational quality control of mitochondrial protein synthesis.

Human molecular genetics

Ng KY,Richter U,Jackson CB,Seneca S,Battersby BJ

Fri Apr 22 00:00:00 UTC 2022

A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement.

Human molecular genetics

Jackson CB,Huemer M,Bolognini R,Martin F,Szinnai G,Donner BC,Richter U,Battersby BJ,Nuoffer JM,Suomalainen A,Schaller A

Fri Feb 15 00:00:00 UTC 2019

A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement.

Human molecular genetics

Jackson CB,Huemer M,Bolognini R,Martin F,Szinnai G,Donner BC,Richter U,Battersby BJ,Nuoffer JM,Suomalainen A,Schaller A

Fri Feb 15 00:00:00 UTC 2019

Mitochondrial stress response triggered by defects in protein synthesis quality control.

Life science alliance

Richter U,Ng KY,Suomi F,Marttinen P,Turunen T,Jackson C,Suomalainen A,Vihinen H,Jokitalo E,Nyman TA,Isokallio MA,Stewart JB,Mancini C,Brusco A,Seneca S,Lombès A,Taylor RW,Battersby BJ

Fri Feb 01 00:00:00 UTC 2019

RNA modification landscape of the human mitochondrial tRNA^Lys regulates protein synthesis.

Nature communications

Richter U,Evans ME,Clark WC,Marttinen P,Shoubridge EA,Suomalainen A,Wredenberg A,Wedell A,Pan T,Battersby BJ

Thu Sep 27 00:00:00 UTC 2018

RNA modification landscape of the human mitochondrial tRNA^Lys regulates protein synthesis.

Nature communications

Richter U,Evans ME,Clark WC,Marttinen P,Shoubridge EA,Suomalainen A,Wredenberg A,Wedell A,Pan T,Battersby BJ

Thu Sep 27 00:00:00 UTC 2018

Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome.

American journal of human genetics

Lake NJ,Webb BD,Stroud DA,Richman TR,Ruzzenente B,Compton AG,Mountford HS,Pulman J,Zangarelli C,Rio M,Boddaert N,Assouline Z,Sherpa MD,Schadt EE,Houten SM,Byrnes J,McCormick EM,Zolkipli-Cunningham Z,Haude K,Zhang Z,Retterer K,Bai R,Calvo SE,Mootha VK,Christodoulou J,Rötig A,Filipovska A,Cristian I,Falk MJ,Metodiev MD,Thorburn DR

Thu Aug 03 00:00:00 UTC 2017

Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome.

American journal of human genetics

Thu Aug 03 00:00:00 UTC 2017

Adult-onset obesity is triggered by impaired mitochondrial gene expression.

Science advances

Perks KL,Ferreira N,Richman TR,Ermer JA,Kuznetsova I,Shearwood AJ,Lee RG,Viola HM,Johnstone VPA,Matthews V,Hool LC,Rackham O,Filipovska A

Tue Aug 01 00:00:00 UTC 2017

Adult-onset obesity is triggered by impaired mitochondrial gene expression.

Science advances

Perks KL,Ferreira N,Richman TR,Ermer JA,Kuznetsova I,Shearwood AJ,Lee RG,Viola HM,Johnstone VPA,Matthews V,Hool LC,Rackham O,Filipovska A

Tue Aug 01 00:00:00 UTC 2017

Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness.

The Journal of cell biology

Richter U,Lahtinen T,Marttinen P,Suomi F,Battersby BJ

Mon Oct 26 00:00:00 UTC 2015

Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness.

The Journal of cell biology

Richter U,Lahtinen T,Marttinen P,Suomi F,Battersby BJ

Mon Oct 26 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: 39S ribosomal protein L11, mitochondrial; cgi-113 protein; L11mt; Large ribosomal subunit protein uL11m; mgc111024; MRP-L11

View more View less

Gene Aliases: 2410001P07Rik; CGI-113; L11MT; MRP-L11; MRPL11

View more View less

UniProt ID: (Human) Q9Y3B7, (Mouse) Q9CQF0, (Rat) Q5XIE3

View more View less

Entrez Gene ID: (Human) 65003, (Mouse) 66419, (Rat) 293666

View more View less

Function(s)

structural constituent of ribosome protein binding rRNA binding poly(A) RNA binding

Process(es)

ribosomal large subunit assembly translation mitochondrial translational elongation mitochondrial translational termination

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

MRPL11 Polyclonal Antibody

MRPL11 Antibody (15543-1-AP) in ICC/IF

Product Details

15543-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!