Proteintech

MRPL3 Polyclonal Antibody

MRPL3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MRPL3 Antibody (16584-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human cervical cancer using 16584-1-AP (MRPL3 antibody) at dilution of 1:100 (under 40x lens).

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Product Details

16584-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MRPL3 Fusion Protein Ag9970 (1-348 aa encoded by BC003375)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPGWRLLTQ VGAQVLGRLG DGLGAALGPG NRTHIWLFVR GLHGKSGTWW DEHLSEENVP FIKQLVSDED KAQLASKLCP LKDEPWPIHP WEPGSFRVGL IALKLGMMPL WTKDGQKHVV TLLQVQDCHV LKYTSKENCN GKMATLSVGG KTVSRFRKAT SILEFYRELG LPPKQTVKIF NITDNAAIKP GTPLYAAHFR PGQYVDVTAK TIGKGFQGVM KRWGFKGQPA THGQTKTHRR PGAVATGDIG RVWPGTKMPG KMGNIYRTEY GLKVWRINTK HNIIYVNGSV PGHKNCLVKV KDSKLPAYKD LGKNLPFPTY FPDGDEEELP EDLYDENVCQ PGAPSITFA (1-348 aa encoded by BC003375 )

Target Information

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors.

eLife

Dennerlein S,Poerschke S,Oeljeklaus S,Wang C,Richter-Dennerlein R,Sattmann J,Bauermeister D,Hanitsch E,Stoldt S,Langer T,Jakobs S,Warscheid B,Rehling P

Fri Dec 31 00:00:00 UTC 2021

The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis.

Nucleic acids research

Lavdovskaia E,Kolander E,Steube E,Mai MM,Urlaub H,Richter-Dennerlein R

Wed Sep 19 00:00:00 UTC 2018

The human Obg protein GTPBP10 is involved in mitoribosomal biogenesis.

Nucleic acids research

Lavdovskaia E,Kolander E,Steube E,Mai MM,Urlaub H,Richter-Dennerlein R

Wed Sep 19 00:00:00 UTC 2018

Mutations in mitochondrial ribosomal protein MRPL12 leads to growth retardation, neurological deterioration and mitochondrial translation deficiency.

Biochimica et biophysica acta

Serre V,Rozanska A,Beinat M,Chretien D,Boddaert N,Munnich A,Rötig A,Chrzanowska-Lightowlers ZM

Thu Aug 01 00:00:00 UTC 2013

Mutations in mitochondrial ribosomal protein MRPL12 leads to growth retardation, neurological deterioration and mitochondrial translation deficiency.

Biochimica et biophysica acta

Serre V,Rozanska A,Beinat M,Chretien D,Boddaert N,Munnich A,Rötig A,Chrzanowska-Lightowlers ZM

Thu Aug 01 00:00:00 UTC 2013

Exome sequencing identifies MRPL3 mutation in mitochondrial cardiomyopathy.

Human mutation

Galmiche L,Serre V,Beinat M,Assouline Z,Lebre AS,Chretien D,Nietschke P,Benes V,Boddaert N,Sidi D,Brunelle F,Rio M,Munnich A,Rötig A

Tue Nov 01 00:00:00 UTC 2011

Exome sequencing identifies MRPL3 mutation in mitochondrial cardiomyopathy.

Human mutation

Galmiche L,Serre V,Beinat M,Assouline Z,Lebre AS,Chretien D,Nietschke P,Benes V,Boddaert N,Sidi D,Brunelle F,Rio M,Munnich A,Rötig A

Tue Nov 01 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: 39S ribosomal protein L3, mitochondrial; L3mt; Large ribosomal subunit protein uL3m; mitochondrial 60S ribosomal protein L3; MRP-L3

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Gene Aliases: 2010320L16Rik; 5930422H18Rik; AA407889; COXPD9; MRL3; MRPL3; RPML3

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UniProt ID: (Human) P09001, (Mouse) Q99N95

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Entrez Gene ID: (Human) 11222, (Rat) 300974, (Mouse) 94062

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Function(s)

RNA binding structural constituent of ribosome poly(A) RNA binding

Process(es)

translation mitochondrial translational elongation mitochondrial translational termination

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MRPL3 Polyclonal Antibody

MRPL3 Antibody (16584-1-AP) in IHC (P)

Product Details

16584-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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