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Immunogen sequence: LAQDLEDMWE QKFLQFKLGA RITEADEKND RTSLNRKLDR NLVLLVREKF GDQDVWILPQ AEWQPGETLR GTAERTLATL SE
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 85%.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 39S ribosomal protein L46, mitochondrial; L46mt; Large ribosomal subunit protein mL46; MRP-L46; P2ECSL
Gene Aliases: C15orf4; LIECG2; MRPL46; P2ECSL
UniProt ID: (Human) Q9H2W6
Entrez Gene ID: (Human) 26589
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