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Proteintech
MSC Polyclonal Antibody
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Product Details
25028-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MSC Fusion Protein Ag13489 (1-206 aa encoded by BC006313)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSTGSVSDP EEMELRGLQR EYPVPASKRP PLRGVERSYA SPSDNSSAEE EDPDGEEERC ALGTAGSAEG CKRKRPRVAG GGGAGGSAGG GGKKPLPAKG SAAECKQSQR NAANARERAR MRVLSKAFSR LKTSLPWVPP DTKLSKLDTL RLASSYIAHL RQLLQEDRYE NGYVHPVNLT WPFVVSGRPD SDTKEVSAAN RLCGTTA (1-206 aa encoded by BC006313)
Target Information
MyoD-E or musculin-E heterodimers bind avidly to consensus E box motifs, which are functionally important elements in the promoter regions of many musclespecific terminal differentiation genes. MyoD complexes potently induce transcriptional activation, while musculin complexes bind adjacent to MyoD DNA-binding regions to represses MyoD activity, which then results in the delayed expression of muscle-specific genes. Musculin is highly expressed in undifferentiated and proliferating myoblasts in culture, and its expression is down regulated during myogenesis and at the onset of terminal differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABF-1; Activated B-cell factor 1; activated B-cell factor 1, homolog of mouse musculin; activated B-cell factor-1; bHLHa22; Class A basic helix-loop-helix protein 22; Musculin; Myogenic repressor
Gene Aliases: ABF-1; ABF1; BHLHA22; MSC; MYOR
UniProt ID: (Human) O60682, (Mouse) O88940
Entrez Gene ID: (Human) 9242, (Mouse) 17681
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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