Invitrogen

MSH2 Recombinant Mouse Monoclonal Antibody (10G3-R)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-50645

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:5,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:2,000
-

Immunocytochemistry (ICC/IF)

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

10G3-R

Immunogen

Synthetic peptide within N-terminal residues of Human MSH2 aa 21-70/934.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 0.1% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3094151

Product Specific Information

Positive control: RAW264.7 cell lysate, PC-12 cell lysate, A431 cell lysate, NIH-3T3 cell lysate, mouse testis tissue lysate, mouse heart tissue lysate, Daudi, human colon cancer tissue, human appendix tissue, human breast cancer tissue, human stomach cancer tissue, rat brain tissue, mouse large intestine tissue.

Predicted band size: 105 kDa

Subcellular Location: Nucleus, Chromosome.

Target Information

Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DNA mismatch repair protein Msh2; hMSH2; mismatch repair protein; Msh2p; mutS homolog 2, colon cancer, nonpolyposis type 1; MutS protein homolog 2

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Gene Aliases: AI788990; COCA1; FCC1; HNPCC; HNPCC1; LCFS2; MSH2

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UniProt ID: (Human) P43246, (Mouse) P43247, (Rat) P54275

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Entrez Gene ID: (Human) 4436, (Mouse) 17685, (Rat) 81709

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Function(s)
magnesium ion binding four-way junction DNA binding Y-form DNA binding heteroduplex DNA loop binding double-strand/single-strand DNA junction binding DNA binding double-stranded DNA binding single-stranded DNA binding protein binding ATP binding protein C-terminus binding ATPase activity centromeric DNA binding enzyme binding protein kinase binding mismatched DNA binding guanine/thymine mispair binding dinucleotide insertion or deletion binding single guanine insertion binding single thymine insertion binding dinucleotide repeat insertion binding oxidized purine DNA binding MutLalpha complex binding protein homodimerization activity ADP binding nucleotide binding damaged DNA binding DNA-dependent ATPase activity single base insertion or deletion binding
Process(es)
meiotic mismatch repair in utero embryonic development somatic recombination of immunoglobulin genes involved in immune response oxidative phosphorylation DNA repair mismatch repair postreplication repair double-strand break repair meiotic gene conversion cellular response to DNA damage stimulus cell cycle cell cycle arrest reciprocal meiotic recombination germ cell development determination of adult lifespan male gonad development intrinsic apoptotic signaling pathway in response to DNA damage response to X-ray response to UV-B somatic hypermutation of immunoglobulin genes somatic recombination of immunoglobulin gene segments B cell mediated immunity B cell differentiation intra-S DNA damage checkpoint intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of neuron apoptotic process maintenance of DNA repeat elements negative regulation of reciprocal meiotic recombination isotype switching negative regulation of DNA recombination positive regulation of helicase activity spermatogenesis response to organic cyclic compound response to drug response to amino acid
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