Proteintech

MSI2 Polyclonal Antibody

MSI2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MSI2 Antibody (10770-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human ovary tumor using 10770-1-AP (MSI2 antibody) at dilution of 1:10 (under 10x lens).

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Product Details

10770-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:8,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:100

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MSI2 Fusion Protein Ag1213 (1-328 aa encoded by BC001526)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEANGSQGT SGSANDSQHD PGKMFIGGLS WQTSPDSLRD YFSKFGEIRE CMVMRDPTTK RSRGFGFVTF ADPASVDKVL GQPHHELDSK TIDPKVAFPR RAQPKMVTRT KKIFVGGLSA NTVVEDVKQY FEQFGKVEDA MLMFDKTTNR HRGFGFVTFE NEDVVEKVCE IHFHEINNKM VECKKAQPKE VMFPPGTRGR ARGLPYTMDA FMLGMGMLGY PNFVATYGRG YPGFAPSYGY QFPGFPAAAY GPVAAAAVAA ARGSGSNPAR PGGFPGANSP GPVADLYGPA SQDSGVGNYI SAASPQPGSG FGHGIAGPLI ATAFTNGYH (1-328 aa encoded by BC001526 )

Target Information

Msi2 (musashi homolog 2), also known as MSI2H, is a 328 amino acid protein that localizes to the cytoplasm and contains two RRM (RNA recognition motif) domains. Expressed ubiquitously at low levels, Msi2 functions as an RNA binding protein that, by regulating the expression of target mRNAs, is thought to play a role in the proliferation and maintenance of stem cells within the central nervous system. Msi2 is subject to posttranslational phosphorylation and is upregulated in response to brain injury, suggesting a role in healing and brain tissue regeneration. Chromosomal aberrations involving the Msi2 gene are associated with the progression of chronic myeloid leukemia. Multiple isoforms of Msi2 exist due to alternative splicing events.Tissue specificity: Ubiquitous; detected at low levels.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

RNA-Binding Protein MSI2 Binds to miR-301a-3p and Facilitates Its Distribution in Mitochondria of Endothelial Cells.

Frontiers in molecular biosciences

Guo QQ,Gao J,Wang XW,Yin XL,Zhang SC,Li X,Chi LL,Zhou XM,Wang Z,Zhang QY

Wed Feb 10 00:00:00 UTC 2021

RNA-Binding Protein MSI2 Binds to miR-301a-3p and Facilitates Its Distribution in Mitochondria of Endothelial Cells.

Frontiers in molecular biosciences

Guo QQ,Gao J,Wang XW,Yin XL,Zhang SC,Li X,Chi LL,Zhou XM,Wang Z,Zhang QY

Wed Feb 10 00:00:00 UTC 2021

RNA-Binding Protein MSI2 Binds to miR-301a-3p and Facilitates Its Distribution in Mitochondria of Endothelial Cells.

Frontiers in molecular biosciences

Guo QQ,Gao J,Wang XW,Yin XL,Zhang SC,Li X,Chi LL,Zhou XM,Wang Z,Zhang QY

Wed Feb 10 00:00:00 UTC 2021

Musashi-2 and related stem cell proteins in the mouse suprachiasmatic nucleus and their potential role in circadian rhythms.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience

Beligala DH,De A,Malik A,Silver R,Rimu K,LeSauter J,McQuillen HJ,Geusz ME

Sat Jun 01 00:00:00 UTC 2019

Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells.

International journal of oncology

Jia W,Jiang X,Liu W,Wang L,Zhu B,Zhu H,Liu X,Zhong M,Xie D,Huang W,Jia W,Li S,Liu X,Zuo X,Cheng D,Dai J,Ren C

Fri Jun 01 00:00:00 UTC 2018

Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells.

International journal of oncology

Jia W,Jiang X,Liu W,Wang L,Zhu B,Zhu H,Liu X,Zhong M,Xie D,Huang W,Jia W,Li S,Liu X,Zuo X,Cheng D,Dai J,Ren C

Fri Jun 01 00:00:00 UTC 2018

Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication.

Science (New York, N.Y.)

Chavali PL,Stojic L,Meredith LW,Joseph N,Nahorski MS,Sanford TJ,Sweeney TR,Krishna BA,Hosmillo M,Firth AE,Bayliss R,Marcelis CL,Lindsay S,Goodfellow I,Woods CG,Gergely F

Fri Jul 07 00:00:00 UTC 2017

Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication.

Science (New York, N.Y.)

Chavali PL,Stojic L,Meredith LW,Joseph N,Nahorski MS,Sanford TJ,Sweeney TR,Krishna BA,Hosmillo M,Firth AE,Bayliss R,Marcelis CL,Lindsay S,Goodfellow I,Woods CG,Gergely F

Fri Jul 07 00:00:00 UTC 2017

Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication.

Science (New York, N.Y.)

Chavali PL,Stojic L,Meredith LW,Joseph N,Nahorski MS,Sanford TJ,Sweeney TR,Krishna BA,Hosmillo M,Firth AE,Bayliss R,Marcelis CL,Lindsay S,Goodfellow I,Woods CG,Gergely F

Fri Jul 07 00:00:00 UTC 2017

Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication.

Science (New York, N.Y.)

Chavali PL,Stojic L,Meredith LW,Joseph N,Nahorski MS,Sanford TJ,Sweeney TR,Krishna BA,Hosmillo M,Firth AE,Bayliss R,Marcelis CL,Lindsay S,Goodfellow I,Woods CG,Gergely F

Fri Jul 07 00:00:00 UTC 2017

Msi2 plays a carcinogenic role in esophageal squamous cell carcinoma via regulation of the Wnt/β-catenin and Hedgehog signaling pathways.

Experimental cell research

Li Z,Jin H,Mao G,Wu L,Guo Q

Fri Dec 01 00:00:00 UTC 2017

Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma.

The EMBO journal

Zhang LF,Lou JT,Lu MH,Gao C,Zhao S,Li B,Liang S,Li Y,Li D,Liu MF

Tue Nov 03 00:00:00 UTC 2015

Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma.

The EMBO journal

Zhang LF,Lou JT,Lu MH,Gao C,Zhao S,Li B,Liang S,Li Y,Li D,Liu MF

Tue Nov 03 00:00:00 UTC 2015

Progenitor stem cell marker expression by pulmonary carcinomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Moreira AL,Gonen M,Rekhtman N,Downey RJ

Tue Jun 01 00:00:00 UTC 2010

Progenitor stem cell marker expression by pulmonary carcinomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Moreira AL,Gonen M,Rekhtman N,Downey RJ

Tue Jun 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: Musashi homolog 2; musashi RNA-binding protein 2; Musashi-2; Musashi2; RNA-binding protein Musashi homolog 2

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Gene Aliases: 1700105C15Rik; AI451722; AI563628; AW489193; MSI2; MSI2H; RGD1560397

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UniProt ID: (Human) Q96DH6, (Mouse) Q920Q6

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Entrez Gene ID: (Human) 124540, (Mouse) 76626, (Rat) 360596

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Function(s)

nucleotide binding protein binding poly(U) RNA binding poly(A) RNA binding nucleic acid binding RNA binding single-stranded RNA binding

Process(es)

stem cell development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MSI2 Polyclonal Antibody

MSI2 Antibody (10770-1-AP) in IHC (P)

Product Details

10770-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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