Proteintech

MSRA Polyclonal Antibody

MSRA Antibody in Immunocytochemistry (ICC/IF)

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MSRA Antibody (14547-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed HEK-293 cells using (Product # 14547-1-AP) (MSRA antibody), at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

MSRA Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MSRA Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

14547-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MSRA Fusion Protein Ag6053 (1-235 aa encoded by BC054033)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLSATRRAC QLLLLHSLFP VPRMGNSASN IVSPQEALPG RKEQTPVAAK HHVNGNRTVE PFPEGTQMAV FGMGCFWGAE RKFWVLKGVY STQVGFAGGY TSNPTYKEVC SEKTGHAEVV RVVYQPEHMS FEELLKVFWE NHDPTQGMRQ GNDHGTQYRS AIYPTSAKQM EAALSSKENY QKVLSEHGFG PITTDIREGQ TFYYAEDYHQ QYLSKNPNGY CGLGGTGVSC PVGIKK (1-235 aa encoded by B C054033)

Target Information

Methionine sulfoxide reductase (MsrA) reduces methionine sulfoxide (MetO) residues in proteins and free MetO to Methionine (Met). The catalytic activity of MsrA is dependent of bound metal and cofactors but it requires reducing equivalents from either DTT or a thioredoxin-regenerating system. MsrA plays an essential role in protecting cells against oxidative damage. The substrates of MsrA include calmodulin, HIV protease and a 1-proteinase-inhibitor. Recent studies indicate that there is a connection between MsrA and Alzheimer's disease in mammals.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Methionine sulfoxide suppresses adipogenic differentiation by regulating the mitogen-activated protein kinase signaling pathway.

Cell biology international

Qin D,Lei Y,Xie W,Zheng Q,Peng Z,Liu Y,Dai B,Ma T,Wei P,Gao C,Guo X,Gao J,Zhao J,Du J,Zeng Q,Zhang Z,Dong X,Shen H

Wed Mar 01 00:00:00 UTC 2023

Recombinant Humanized IgG1 Antibody Protects against oxLDL-Induced Oxidative Stress and Apoptosis in Human Monocyte/Macrophage THP-1 Cells by Upregulation of MSRA via Sirt1-FOXO1 Axis.

International journal of molecular sciences

Zhang Q,Li Z,Liu X,Zhao M

Mon Oct 03 00:00:00 UTC 2022

Recombinant Humanized IgG1 Antibody Protects against oxLDL-Induced Oxidative Stress and Apoptosis in Human Monocyte/Macrophage THP-1 Cells by Upregulation of MSRA via Sirt1-FOXO1 Axis.

International journal of molecular sciences

Zhang Q,Li Z,Liu X,Zhao M

Mon Oct 03 00:00:00 UTC 2022

Methionine strengthens anti-inflammation of rice protein via depressing NF-κB activation and stimulating Msr expression in rats fed cholesterol-enriched diets.

Food science and biotechnology

Wang Z,Liang M,Liu B,Yang L

Wed Jun 01 00:00:00 UTC 2022

Fecal Microbiota Transplantation Is a Promising Method to Restore Gut Microbiota Dysbiosis and Relieve Neurological Deficits after Traumatic Brain Injury.

Oxidative medicine and cellular longevity

Du D,Tang W,Zhou C,Sun X,Wei Z,Zhong J,Huang Z

Thu Sep 09 00:00:00 UTC 2021

Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats.

Journal of food biochemistry

Wang Z,Cai L,Li H,Liang M,Zhang Y,Wu Q,Yang L

Fri May 01 00:00:00 UTC 2020

The Antioxidant Enzyme Methionine Sulfoxide Reductase A (MsrA) Interacts with Jab1/CSN5 and Regulates Its Function.

Antioxidants (Basel, Switzerland)

Jiang B,Adams Z,Moonah S,Shi H,Maupin-Furlow J,Moskovitz J

Sun May 24 00:00:00 UTC 2020

Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.

Journal of medicinal food

Li H,Liang M,Wang Z,Zhang Y,Wu Q,Yang L

Mon Jun 01 00:00:00 UTC 2020

Loss of methionine sulfoxide reductases increases resistance to oxidative stress.

Free radical biology & medicine

Lai L,Sun J,Tarafdar S,Liu C,Murphy E,Kim G,Levine RL

Sun Dec 01 00:00:00 UTC 2019

l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats.

Journal of the science of food and agriculture

Wang Z,Liang M,Li H,Cai L,He H,Wu Q,Yang L

Thu Aug 15 00:00:00 UTC 2019

Analysis of EV71 infection progression using triple-SILAC-based proteomics approach.

Proteomics

Li HY,Zhang LK,Zhu XJ,Shang J,Chen X,Zhu Y,Guo L

Sun Nov 01 00:00:00 UTC 2015

Analysis of EV71 infection progression using triple-SILAC-based proteomics approach.

Proteomics

Li HY,Zhang LK,Zhu XJ,Shang J,Chen X,Zhu Y,Guo L

Sun Nov 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: cytosolic methionine-S-sulfoxide reductase; Mitochondrial peptide methionine sulfoxide reductase; peptide met (O) reductase; Peptide Met(O) reductase; peptide methionine sulfoxide reductase; Peptide-methionine (S)-S-oxide reductase; PMSR; Protein-methionine-S-oxide reductase

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Gene Aliases: 2310045J23Rik; 6530413P12Rik; MSR-A; MSRA; PMSR

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UniProt ID: (Human) Q9UJ68, (Rat) Q923M1, (Mouse) Q9D6Y7

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Entrez Gene ID: (Human) 4482, (Rat) 29447, (Mouse) 110265

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Function(s)

peptide-methionine (S)-S-oxide reductase activity oxidoreductase activity oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

Process(es)

response to oxidative stress aging protein repair oxidation-reduction process cellular protein modification process methionine metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MSRA Polyclonal Antibody

MSRA Antibody (14547-1-AP) in ICC/IF

Product Details

14547-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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