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Bioss
MST1R Polyclonal Antibody
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Product Details
BS-4132R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human MST1R/Ron, amino acids 151-250.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uteru.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-met-related tyrosine kinase; CD136; CDw136; friend virus susceptibility 2; Macrophage-stimulating protein receptor; MSP receptor; MST1R variant RON30; MST1R variant RON62; p185-Ron; protein tyrosine kinase 8; Protein-tyrosine kinase 8; PTK8 protein tyrosine kinase 8; receptor protein tyrosine kinase, c-met-related; RON variant E2E3; Stem cell-derived tyrosine kinase
Gene Aliases: CD136; CDw136; Fv-2; Fv2; MST1R; PTK8; RON; STK
UniProt ID: (Human) Q04912, (Mouse) Q62190
Entrez Gene ID: (Human) 4486, (Rat) 300999, (Mouse) 19882
macrophage colony-stimulating factor receptor activity
protein binding
ATP binding
enzyme binding
transmembrane receptor protein tyrosine kinase activity
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
movement of cell or subcellular component
defense response
signal transduction
single fertilization
positive regulation of cell proliferation
response to virus
peptidyl-tyrosine phosphorylation
macrophage colony-stimulating factor signaling pathway
positive regulation of MAP kinase activity
innate immune response
hepatocyte growth factor receptor signaling pathway
positive regulation of protein kinase B signaling
multicellular organism development
immune system process
protein phosphorylation
viral process
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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