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Product Details
PA5-22269
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human MST3. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.94 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11152408
Product Specific Information
Recommended positive controls: 293T, A431, H1299, HeLa, Raji, rat brain.
Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
STK24 (MST3) is a serine/threonine kinase that is a member of the GCK subfamily of STE20-like proteins. The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory protein Li 95; Mammalian STE20-like protein kinase 3; MST-3; OTTHUMP00000018594; RP11-111L24.5; serine/threonine kinase 24 (STE20 homolog, yeast); Serine/threonine-protein kinase 24; STE20-like kinase 3; STE20-like kinase MST3; sterile 20-like kinase 3
Gene Aliases: HEL-S-95; MST-3; MST3; MST3B; RGD1561742; STE20; STK24; STK3
UniProt ID: (Human) Q9Y6E0, (Rat) B0LT89
Entrez Gene ID: (Human) 8428, (Rat) 361092
mitotic cell cycle
protein phosphorylation
cellular component disassembly involved in execution phase of apoptosis
signal transduction
intrinsic apoptotic signaling pathway in response to oxidative stress
signal transduction by protein phosphorylation
negative regulation of cell migration
response to hydrogen peroxide
protein autophosphorylation
regulation of axon regeneration
execution phase of apoptosis
cell-cell adhesion
apoptotic process
intracellular signal transduction
positive regulation of axon regeneration
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