Invitrogen

MSX1 Polyclonal Antibody

View all (16) MSX1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-23176

Applications
Tested Dilution
Publications

Western Blot (WB)

1-3 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2.5-5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A portion of amino acids 50-100 of human HOX7
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2540702

Target Information

MSX1 is a member of the muscle segment homeobox gene family. It functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. MSX1 may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition. Mutations in the gene, which was once known as homeobox 7, have been associated with nonsyndromic cleft lip with or without cleft palate 5, Witkop syndrome, Wolf-Hirschom syndrome, and autosomoal dominant hypodontia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: homeo box, msh-like 1; homeobox 7; Homeobox protein Hox-7; Homeobox protein MSX-1; homeobox, msh-like 1; Hox-7.1; msh homeo box 1; Msh homeobox 1-like protein; msh homeobox homolog 1; muscle-segment homeobox

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Gene Aliases: AA675338; AI324650; ECTD3; Hox-7; HOX7; Hox7.1; HYD1; msh; MSX1; STHAG1

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UniProt ID: (Human) P28360, (Mouse) P13297

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Entrez Gene ID: (Human) 4487, (Mouse) 17701, (Rat) 81710

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding DNA binding protein binding sequence-specific DNA binding molecular_function
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis in utero embryonic development epithelial to mesenchymal transition involved in endocardial cushion formation transcription from RNA polymerase II promoter muscle organ development negative regulation of cell proliferation anterior/posterior pattern specification mesenchymal cell proliferation signal transduction involved in regulation of gene expression negative regulation of cell growth positive regulation of BMP signaling pathway forebrain development midbrain development protein localization to nucleus embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic nail plate morphogenesis middle ear morphogenesis odontogenesis of dentin-containing tooth regulation of odontogenesis negative regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of transcription from RNA polymerase II promoter stem cell differentiation protein stabilization negative regulation of striated muscle cell differentiation palate development face morphogenesis bone morphogenesis cartilage morphogenesis mammary gland epithelium development BMP signaling pathway involved in heart development activation of meiosis positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of transcription regulatory region DNA binding positive regulation of mesenchymal cell apoptotic process epithelial to mesenchymal transition heart morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development heart development embryonic limb morphogenesis BMP signaling pathway odontogenesis embryonic digit morphogenesis negative regulation of DNA binding negative regulation of transcription, DNA-templated cartilage development pituitary gland development cellular response to nicotine
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