Invitrogen

MSX1/MSX2 Polyclonal Antibody

Promotion

View available promotion(s)

Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-103302

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human MSX1(Accession P28360), corresponding to amino acid residues W145-Q195.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2852649

Product Specific Information

Antibody detects endogenous levels of total MSX1/2.

Target Information

Drosophila,muscle segment (msh) homolog 1,homeo domain encoding gene,inhibiting MYOD1 expression,highly expressed in dental mesenchyme during critical bud stage,involved in epithelial-mesenchymal signaling in many organs,and in the pathogenesis of cleft lip and palate,interacting with MSX2 in mouse limb bud patterning .This gene encodes a member of the muscle segment homeobox gene family. The encoded protein functions as a transcriptional repressor during embryogenesis through interactions with components of the core transcription complex and other homeoproteins. It may also have roles in limb-pattern formation, craniofacial development, particularly odontogenesis, and tumor growth inhibition.Tissue specificity: Expressed in the developing nail bed mesenchyme.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: homeo box, msh-like 1; homeo box, msh-like 2; homeobox 7; Homeobox protein Hox-7; Homeobox protein Hox-8; Homeobox protein Hox-8-1; Homeobox protein MSX-1; Homeobox protein MSX-2; homeobox, msh-like 1; homeobox, msh-like 2; Hox-7.1; hox-8.1; msh homeo box 1; msh homeo box 2; msh homeo box homolog 2; Msh homeobox 1-like protein; msh homeobox homolog 1; msh homeobox homolog 2; muscle-segment homeobox

View more View less

Gene Aliases: AA675338; AI324650; BB122635; CRS2; ECTD3; FPP; Hox-7; Hox-8; Hox-8.1; HOX7; Hox7.1; HOX8; Hox8.1; HYD1; MSH; Msx-2; MSX1; MSX2; PFM; PFM1; STHAG1

View more View less

UniProt ID: (Human) P28360, (Human) P35548, (Mouse) P13297, (Mouse) Q03358

View more View less

Entrez Gene ID: (Human) 4487, (Human) 4488, (Mouse) 17701, (Rat) 81710, (Mouse) 17702, (Rat) 25483

View more View less

Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding p53 binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription cofactor activity protein binding transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding DNA binding molecular_function transcription factor activity, transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell morphogenesis in utero embryonic development epithelial to mesenchymal transition involved in endocardial cushion formation transcription from RNA polymerase II promoter muscle organ development negative regulation of cell proliferation anterior/posterior pattern specification mesenchymal cell proliferation signal transduction involved in regulation of gene expression negative regulation of cell growth positive regulation of BMP signaling pathway forebrain development midbrain development protein localization to nucleus embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic nail plate morphogenesis middle ear morphogenesis odontogenesis of dentin-containing tooth regulation of odontogenesis negative regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of transcription from RNA polymerase II promoter stem cell differentiation protein stabilization negative regulation of striated muscle cell differentiation palate development face morphogenesis bone morphogenesis cartilage morphogenesis mammary gland epithelium development BMP signaling pathway involved in heart development activation of meiosis positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of transcription regulatory region DNA binding positive regulation of mesenchymal cell apoptotic process osteoblast differentiation chondrocyte development osteoblast development outflow tract septum morphogenesis endochondral bone growth negative regulation of CREB transcription factor activity wound healing, spreading of epidermal cells negative regulation of fat cell differentiation negative regulation of keratinocyte differentiation positive regulation of osteoblast differentiation negative regulation of transcription, DNA-templated positive regulation of catagen bone trabecula formation cranial suture morphogenesis frontal suture morphogenesis branching involved in mammary gland duct morphogenesis enamel mineralization cellular response to estradiol stimulus ossification outflow tract morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter multicellular organism development embryonic limb morphogenesis BMP signaling pathway wound healing odontogenesis anagen embryonic digit morphogenesis regulation of apoptotic process positive regulation of apoptotic process cartilage development cellular response to growth factor stimulus epithelial to mesenchymal transition heart morphogenesis heart development negative regulation of DNA binding pituitary gland development cellular response to nicotine
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support