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Invitrogen
MSX2 Polyclonal Antibody
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Product Details
PA5-41436
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal of human MSX2 (aa 1-50).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608898
Product Specific Information
Peptide sequence: MASPSKGNDL FSPDEEGPAV VAGPGPGPGG AEGAAEERRV KVSSLPFSVE
Sequence homology: Cow: 100%; Dog: 100%; Goat: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%
Target Information
Msx2 is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. This protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in the Msx2 gene are associated with parietal foramina 1 and craniosynostosis type 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeobox protein Hox-8; Homeobox protein MSX-2; msh homeo box 2; msh homeobox homolog 2
Gene Aliases: CRS2; FPP; HOX8; MSH; MSX2; PFM; PFM1
UniProt ID: (Human) P35548
Entrez Gene ID: (Human) 4488
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcription cofactor activity
protein binding
transcription factor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
chondrocyte development
osteoblast development
outflow tract septum morphogenesis
epithelial to mesenchymal transition involved in endocardial cushion formation
endochondral bone growth
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
anterior/posterior pattern specification
signal transduction involved in regulation of gene expression
positive regulation of BMP signaling pathway
negative regulation of CREB transcription factor activity
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
wound healing, spreading of epidermal cells
embryonic nail plate morphogenesis
negative regulation of apoptotic process
negative regulation of fat cell differentiation
negative regulation of keratinocyte differentiation
positive regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
stem cell differentiation
positive regulation of catagen
bone trabecula formation
cranial suture morphogenesis
frontal suture morphogenesis
branching involved in mammary gland duct morphogenesis
BMP signaling pathway involved in heart development
enamel mineralization
cellular response to estradiol stimulus
activation of meiosis
negative regulation of transcription regulatory region DNA binding
positive regulation of mesenchymal cell apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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