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Product Details
PA5-52042
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human MT3. Recombinant protein control fragment (Product #RP-102274).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2644244
Product Specific Information
Immunogen sequence: MDPETCPCPS GGSCTCADSC KCEGCKCTSC KKSCCSCCPA ECEKCAKDCV CKGGEAAEAE AEKCS
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 83%.
Target Information
Metallothionein (MT) is a sulfhydryl- and cysteine-rich protein found in micro-organisms, plants and all invertebrate and vertebrate animals. Metallothioneins are a group of ubiquitous low-molecular-weight proteins that have functional roles in cell growth, repair and differentiation. Metallothionein are implicated primarily in metal ion detoxification as they are essential for the protection of cells against the toxicity of cadmium, mercury and copper. Metallothioneins are known to be broadly expressed in heart, liver, kidney, breast and testis tissue. Metallothionein 3, also known as MT-3 or GIFB (growth inhibitory factor), is a 68 amino acid protein that belongs to the type 1 family and Metallothionein superfamily. While highly expressed in astrocytes of the normal human brain, Metallothionein 3 expression is reduced in the brains of patients with Alzheimer disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GIF; GIFB; Growth inhibitory factor; metallothionein 3 (growth inhibitory factor (neurotrophic)); Metallothionein-3; Metallothionein-III; MT-3; MT-III
Gene Aliases: GIF; GIFB; GRIF; MT3; ZnMT3
UniProt ID: (Human) P25713
Entrez Gene ID: (Human) 4504
protein import into nucleus, translocation
response to hypoxia
positive regulation of protein phosphorylation
energy reserve metabolic process
cholesterol catabolic process
zinc II ion transport
cellular metal ion homeostasis
cellular zinc ion homeostasis
apoptotic process
brain development
cell proliferation
response to metal ion
negative regulation of autophagy
positive regulation of gene expression
positive regulation of necrotic cell death
positive regulation of cell death
astrocyte development
histone modification
removal of superoxide radicals
negative regulation of cell growth
negative regulation of axon extension
positive regulation of vascular endothelial growth factor receptor signaling pathway
regulation of response to food
activation of protein kinase B activity
leptin-mediated signaling pathway
cellular response to oxidative stress
cellular response to drug
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress
negative regulation of apoptotic process
positive regulation of catalytic activity
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein kinase B signaling
negative regulation of neuron apoptotic process
cellular lipid catabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
protein stabilization
negative regulation of oxidoreductase activity
zinc ion homeostasis
cadmium ion homeostasis
regulation of protein glycosylation
negative regulation of necrotic cell death
ERK1 and ERK2 cascade
positive regulation of ERK1 and ERK2 cascade
cellular response to cadmium ion
cellular response to hypoxia
cellular response to nitric oxide
positive regulation of lysosomal membrane permeability
negative regulation of cysteine-type endopeptidase activity
negative regulation of hydrogen peroxide catabolic process
positive regulation of oxygen metabolic process
negative regulation of reactive oxygen species metabolic process
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