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Invitrogen
MTA1 Polyclonal Antibody
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MTA1 Antibody (PA5-79699) in IHC (P)
Immunohistochemical analysis of MTA1 in paraffin-embedded section of human pancrease cancer tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution).The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1μg/mL rabbit anti-MTA1 antibody (Product # PA5-79699) overnight at 4°C. Biotinylated goat anti-rabbit IgG was used a... View More
Product Details
PA5-79699
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human MTA1 (676-696aa ETKRAARRPYKPIALRQSQAL).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2746814
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human MCF-7 whole cell, human HEK293 whole cell, human HELA whole cell, human PC-3 whole cell, human Raji whole cell, human K562 whole cell, rat brain tissue, mouse brain tissue. IHC: Human Rectal Cancer Tissue, rat ovary tissue, rat ovary tissue, mouse brain tissue, human ovarian cancer tissue, human pancrease cancer tissue IHC-F: Rat Ovary Tissue, mouse brain tissue.
Target Information
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: metastasis associated gene 1 protein; Metastasis-associated protein MTA1
Gene Aliases: MTA1; Zg29
UniProt ID: (Human) Q13330, (Rat) Q62599
Entrez Gene ID: (Human) 9112, (Rat) 64520, (Mouse) 116870
core promoter sequence-specific DNA binding
core promoter binding
RNA polymerase II repressing transcription factor binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
histone deacetylase activity
protein binding
zinc ion binding
enzyme binding
sequence-specific DNA binding
DNA binding
metal ion binding
double-strand break repair
transcription, DNA-templated
regulation of transcription, DNA-templated
female pregnancy
response to ionizing radiation
response to lipopolysaccharide
circadian regulation of gene expression
secretory granule organization
regulation of gene expression, epigenetic
entrainment of circadian clock by photoperiod
proteasome-mediated ubiquitin-dependent protein catabolic process
locomotor rhythm
regulation of inflammatory response
positive regulation of protein autoubiquitination
regulation of nucleic acid-templated transcription
negative regulation of nucleic acid-templated transcription
rhythmic process
signal transduction
histone deacetylation
protein sumoylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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