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Abnova
MTA1 Monoclonal Antibody (4D5)
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Product Details
H00009112-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG3, kappa
Class
Monoclonal
Type
Antibody
Clone
4D5
Immunogen
MTA1 (NP_004680, 601 a.a. approximately 700 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MPSRGLANHG QTRHMGPSRN LLLNGKSYPT KVRLIRGGSL PPVKRRRMNW IDAPDDVFYM ATEETRKIRK LLSSSETKRA ARRPYKPIAL RQSQALPPRP
Target Information
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: metastasis associated gene 1 protein; Metastasis-associated protein MTA1
Gene Aliases: MTA1; Zg29
UniProt ID: (Human) Q13330, (Rat) Q62599
Entrez Gene ID: (Human) 9112, (Rat) 64520, (Mouse) 116870
core promoter sequence-specific DNA binding
core promoter binding
RNA polymerase II repressing transcription factor binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
histone deacetylase activity
protein binding
zinc ion binding
enzyme binding
sequence-specific DNA binding
DNA binding
metal ion binding
double-strand break repair
transcription, DNA-templated
regulation of transcription, DNA-templated
female pregnancy
response to ionizing radiation
response to lipopolysaccharide
circadian regulation of gene expression
secretory granule organization
regulation of gene expression, epigenetic
entrainment of circadian clock by photoperiod
proteasome-mediated ubiquitin-dependent protein catabolic process
locomotor rhythm
regulation of inflammatory response
positive regulation of protein autoubiquitination
regulation of nucleic acid-templated transcription
negative regulation of nucleic acid-templated transcription
rhythmic process
signal transduction
histone deacetylation
protein sumoylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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