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MTA3 Polyclonal Antibody

MTA3 Antibody in Immunocytochemistry (ICC/IF)

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MTA3 Antibody (14682-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using MTA3 antibody 14682-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

MTA3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

MTA3 Antibody in Immunoprecipitation (IP)

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Product Details

14682-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MTA3 Fusion Protein Ag6400 (1-343 aa encoded by BC053631)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAANMYRVG DYVYFENSSS NPYLIRRIEE LNKTASGNVE AKVVCFYRRR DISNTLIMLA DKHAKEIEEE SETTVEADLT DKQKHQLKHR ELFLSRQYES LPATHIRGKC SVALLNETES VLSYLDKEDT FFYSLVYDPS LKTLLADKGE IRVGPRYQAD IPEMLLEGES DEREQSKLEV KVWDPNSPLT DRQIDQFLVV ARAVGTFARA LDCSSSVRQP SLHMSAAAAS RDITLFHAMD TLYRHSYDLS SAISVLVPLG GPVLCRDEME EWSASEASLF EEALEKYGKD FNDIRQDFLP WKSLTSIIEY YYMWKTTDRY VQQKRLKAAE AESKLKQVYI PTYS (1-343 aa encoded by BC053631)

Target Information

Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6. [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis.

Cellular & molecular immunology

Lau P,Zhang G,Zhao S,Liang L,Zhang H,Zhou G,Hung MC,Chen X,Liu H

Sat Oct 01 00:00:00 UTC 2022

Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis.

Cellular & molecular immunology

Lau P,Zhang G,Zhao S,Liang L,Zhang H,Zhou G,Hung MC,Chen X,Liu H

Sat Oct 01 00:00:00 UTC 2022

Elevated MTA1 induced the migration and invasion of renal cell carcinoma through the NF-κB pathway.

BMC urology

Lv C,Huang Y,Lei Q,Liu Z,Shen S,Si W

Thu Oct 15 00:00:00 UTC 2020

The Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure at Sites of Active Transcription to Fine-Tune Gene Expression.

Molecular cell

Bornelöv S,Reynolds N,Xenophontos M,Gharbi S,Johnstone E,Floyd R,Ralser M,Signolet J,Loos R,Dietmann S,Bertone P,Hendrich B

Thu Jul 05 00:00:00 UTC 2018

The Nucleosome Remodeling and Deacetylation Complex Modulates Chromatin Structure at Sites of Active Transcription to Fine-Tune Gene Expression.

Molecular cell

Bornelöv S,Reynolds N,Xenophontos M,Gharbi S,Johnstone E,Floyd R,Ralser M,Signolet J,Loos R,Dietmann S,Bertone P,Hendrich B

Thu Jul 05 00:00:00 UTC 2018

Correlation of metastasis-associated protein expression with prognosis and chemotherapy in nasopharyngeal carcinoma.

International journal of clinical and experimental pathology

Zhang BJ,Lan GP,Si JY,Li YL,Huang B,Deng ZX,Si YF,Chen MM,Shen XY,Wang Y

Sun Jan 19 00:00:00 UTC 2020

Overexpression of the metastasis-associated gene MTA3 correlates with tumor progression and poor prognosis in hepatocellular carcinoma.

Journal of gastroenterology and hepatology

Wang C,Li G,Li J,Li J,Li T,Yu J,Qin C

Tue Aug 01 00:00:00 UTC 2017

Overexpression of the metastasis-associated gene MTA3 correlates with tumor progression and poor prognosis in hepatocellular carcinoma.

Journal of gastroenterology and hepatology

Wang C,Li G,Li J,Li J,Li T,Yu J,Qin C

Tue Aug 01 00:00:00 UTC 2017

MTA3 regulates malignant progression of colorectal cancer through Wnt signaling pathway.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Jiao T,Li Y,Gao T,Zhang Y,Feng M,Liu M,Zhou H,Sun M

Wed Mar 01 00:00:00 UTC 2017

MTA3 regulates malignant progression of colorectal cancer through Wnt signaling pathway.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Jiao T,Li Y,Gao T,Zhang Y,Feng M,Liu M,Zhou H,Sun M

Wed Mar 01 00:00:00 UTC 2017

MTA3 regulates malignant progression of colorectal cancer through Wnt signaling pathway.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Jiao T,Li Y,Gao T,Zhang Y,Feng M,Liu M,Zhou H,Sun M

Wed Mar 01 00:00:00 UTC 2017

MTA3 regulates malignant progression of colorectal cancer through Wnt signaling pathway.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Jiao T,Li Y,Gao T,Zhang Y,Feng M,Liu M,Zhou H,Sun M

Wed Mar 01 00:00:00 UTC 2017

Metastasis-associated protein 3 in colorectal cancer determines tumor recurrence and prognosis.

Oncotarget

Huang Y,Li Y,He F,Wang S,Li Y,Ji G,Liu X,Zhao Q,Li J

Tue Jun 06 00:00:00 UTC 2017

Metastasis-associated protein 3 in colorectal cancer determines tumor recurrence and prognosis.

Oncotarget

Huang Y,Li Y,He F,Wang S,Li Y,Ji G,Liu X,Zhao Q,Li J

Tue Jun 06 00:00:00 UTC 2017

Expression of metastasis-associated protein 3 in human brain glioma related to tumor prognosis.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Shan S,Hui G,Hou F,Shi H,Zhou G,Yan H,Wang L,Liu J

Thu Oct 01 00:00:00 UTC 2015

Expression of metastasis-associated protein 3 in human brain glioma related to tumor prognosis.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Shan S,Hui G,Hou F,Shi H,Zhou G,Yan H,Wang L,Liu J

Thu Oct 01 00:00:00 UTC 2015

MiR-495 regulates proliferation and migration in NSCLC by targeting MTA3.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Chu H,Chen X,Wang H,Du Y,Wang Y,Zang W,Li P,Li J,Chang J,Zhao G,Zhang G

Tue Apr 01 00:00:00 UTC 2014

Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer.

PloS one

Li H,Sun L,Xu Y,Li Z,Luo W,Tang Z,Qiu X,Wang E

Fri Oct 06 00:00:00 UTC 2017

Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer.

PloS one

Li H,Sun L,Xu Y,Li Z,Luo W,Tang Z,Qiu X,Wang E

Fri Oct 06 00:00:00 UTC 2017

Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer.

PloS one

Li H,Sun L,Xu Y,Li Z,Luo W,Tang Z,Qiu X,Wang E

Fri Oct 06 00:00:00 UTC 2017

Overexpression of MTA3 Correlates with Tumor Progression in Non-Small Cell Lung Cancer.

PloS one

Li H,Sun L,Xu Y,Li Z,Luo W,Tang Z,Qiu X,Wang E

Fri Oct 06 00:00:00 UTC 2017

The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.

Cell stem cell

Qin J,Whyte WA,Anderssen E,Apostolou E,Chen HH,Akbarian S,Bronson RT,Hochedlinger K,Ramaswamy S,Young RA,Hock H

Fri Sep 07 00:00:00 UTC 2012

The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.

Cell stem cell

Qin J,Whyte WA,Anderssen E,Apostolou E,Chen HH,Akbarian S,Bronson RT,Hochedlinger K,Ramaswamy S,Young RA,Hock H

Fri Sep 07 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: metastasis associated 1 family, member 3; metastasis associated 3; metastasis associated family, member 3; metastasis associated gene family, member 3; Metastasis-associated protein MTA3

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Gene Aliases: 1110002J22Rik; KIAA1266; mKIAA1266; MTA3

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UniProt ID: (Human) Q9BTC8, (Mouse) Q924K8

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Entrez Gene ID: (Human) 57504, (Mouse) 116871, (Rat) 100362346

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Function(s)

chromatin binding transcription factor activity, sequence-specific DNA binding histone deacetylase activity protein binding zinc ion binding sequence-specific DNA binding DNA binding metal ion binding molecular_function

Process(es)

regulation of transcription, DNA-templated positive regulation of cell proliferation positive regulation of G2/M transition of mitotic cell cycle negative regulation of transcription, DNA-templated biological_process histone deacetylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MTA3 Polyclonal Antibody

MTA3 Antibody (14682-1-AP) in ICC/IF

Product Details

14682-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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