Product References
Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired.
Nature communications
Liang W,Sagar S,Ravindran R,Najor RH,Quiles JM,Chi L,Diao RY,Woodall BP,Leon LJ,Zumaya E,Duran J,Cauvi DM,De Maio A,Adler ED,Gustafsson ÅB
459600 was used in Western Blot to establish that mitochondria are eliminated in large EVs through the endosomal pathway when lysosomal degradation is inhibited.
Fri Aug 18 00:00:00 UTC 2023
Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired.
Nature communications
Liang W,Sagar S,Ravindran R,Najor RH,Quiles JM,Chi L,Diao RY,Woodall BP,Leon LJ,Zumaya E,Duran J,Cauvi DM,De Maio A,Adler ED,Gustafsson ÅB
459600 was used in Western Blot to establish that mitochondria are eliminated in large EVs through the endosomal pathway when lysosomal degradation is inhibited.
Fri Aug 18 00:00:00 UTC 2023
Principles of mitoribosomal small subunit assembly in eukaryotes.
Nature
Harper NJ,Burnside C,Klinge S
459600 was used in Western Blotting to determine nine structures of native yeast and human mitoribosomal small subunit assembly intermediates, illuminating the mechanistic basis for how GTPases are used to control early steps of decoding centre formation, how initial rRNA folding and processing events are mediated, and how mitoribosomal proteins have active roles during assembly.
Wed Feb 01 00:00:00 UTC 2023
Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo.
Acta pharmaceutica Sinica. B
Ouyang X,Wani WY,Benavides GA,Redmann MJ,Vo H,van Groen T,Darley-Usmar VM,Zhang J
459600 was used in Western Blot to find that over-expression of Cathepsin D extended the lifespan of the CDKO mice, partially rescues proteasomal deficits and the accumulation of Aβ42 in the CDKO.
Sun Oct 01 00:00:00 UTC 2023
Protein engineering reveals that gasdermin A preferentially targets mitochondrial membranes over the plasma membrane during pyroptosis.
The Journal of biological chemistry
Kondolf HC,D'Orlando DA,Dubyak GR,Abbott DW
459600 was used in Immunocytochemistry to develop a system that activates gasdermin family members in an efficient and equivalent manner.
Wed Feb 01 00:00:00 UTC 2023
A novel splice variant of Elp3/Kat9 regulates mitochondrial tRNA modification and function.
Scientific reports
Boutoual R,Jo H,Heckenbach I,Tiwari R,Kasler H,Lerner CA,Shah S,Schilling B,Calvanese V,Rardin MJ,Scheibye-Knudsen M,Verdin E
Published figure using MTCO1 monoclonal antibody (Product # 459600) in Western Blot
Wed Aug 31 00:00:00 UTC 2022
Ixodes ricinus ticks have a functional association with Midichloria mitochondrii.
Frontiers in cellular and infection microbiology
Guizzo MG,Hatalová T,Frantová H,Zurek L,Kopáček P,Perner J
459600 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that M. mitochondrii represents an integral component of tick ovarian tissue, and when absent, results in the formation of substandard larvae with reduced capacity to blood-feed.
Fri Jan 27 00:00:00 UTC 2023
Ixodes ricinus ticks have a functional association with Midichloria mitochondrii.
Frontiers in cellular and infection microbiology
Guizzo MG,Hatalová T,Frantová H,Zurek L,Kopáček P,Perner J
459600 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to indicate that M. mitochondrii represents an integral component of tick ovarian tissue, and when absent, results in the formation of substandard larvae with reduced capacity to blood-feed.
Fri Jan 27 00:00:00 UTC 2023
RCCS Bioreactor-Based Modeled Microgravity Affects Gastric Cancer Cells and Improves the Chemotherapeutic Effect.
Membranes
Rembiałkowska N,Baczyńska D,Dubińska-Magiera M,Choromańska A,Bieżuńska-Kusiak K,Gajewska-Naryniecka A,Novickij V,Saczko J,Przystupski D,Kulbacka J
Published figure using MTCO1 monoclonal antibody (Product # 459600) in Immunocytochemistry
Thu Apr 21 00:00:00 UTC 2022
Destabilizing COXIV in Müller Glia Increases Retinal Glycolysis and Alters Scotopic Electroretinogram.
Cells
Nsiah NY,Inman DM
459600 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that MG were able to compensate for reduced COXIV stability by maintaining fundamental processes, but changes in retinal physiology and metabolism-associated proteins indicate subtle changes in MG function.
Thu Nov 24 00:00:00 UTC 2022
Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity.
EBioMedicine
Pileggi CA,Blondin DP,Hooks BG,Parmar G,Alecu I,Patten DA,Cuillerier A,O'Dwyer C,Thrush AB,Fullerton MD,Bennett SA,Doucet É,Haman F,Cuperlovic-Culf M,McPherson R,Dent RRM,Harper ME
459600 was used in Western Blotting to show that these clinical and metabolic mechanism insights move the field towards better personalised approaches for the treatment of distinct obesity phenotypes.
Thu Sep 01 00:00:00 UTC 2022
Protein Kinase A in Human Retina: Differential Localization of Cβ, Cα, RIIα, and RIIβ in Photoreceptors Highlights Non-redundancy of Protein Kinase A Subunits.
Frontiers in molecular neuroscience
Roa JN,Ma Y,Mikulski Z,Xu Q,Ilouz R,Taylor SS,Skowronska-Krawczyk D
459600 was used in Western Blot to indicate that PKA Cα, Cβ, RIIα, and RIIβ subunits are differentially localized and are likely functionally non-redundant in the human retina, and that Cβ is potentially important for mitochondrial-associated neurodegenerative diseases previously linked to PKA dysfunction.
Sat Jul 01 00:00:00 UTC 2023
Protein Kinase A in Human Retina: Differential Localization of Cβ, Cα, RIIα, and RIIβ in Photoreceptors Highlights Non-redundancy of Protein Kinase A Subunits.
Frontiers in molecular neuroscience
Roa JN,Ma Y,Mikulski Z,Xu Q,Ilouz R,Taylor SS,Skowronska-Krawczyk D
459600 was used in Western Blot to indicate that PKA Cα, Cβ, RIIα, and RIIβ subunits are differentially localized and are likely functionally non-redundant in the human retina, and that Cβ is potentially important for mitochondrial-associated neurodegenerative diseases previously linked to PKA dysfunction.
Sat Jul 01 00:00:00 UTC 2023
Loss of Mitochondrial Protease CLPP Activates Type I IFN Responses through the Mitochondrial DNA-cGAS-STING Signaling Axis.
Journal of immunology (Baltimore, Md. : 1950)
Torres-Odio S,Lei Y,Gispert S,Maletzko A,Key J,Menissy SS,Wittig I,Auburger G,West AP
459600 was used in Western Blotting to place the cGAS-STING-IFN-I innate immune pathway downstream of CLPP and may have implications for understanding Perrault syndrome and other human diseases involving CLPP dysregulation.
Thu Apr 15 00:00:00 UTC 2021
The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.
Cell reports
Acoba MG,Alpergin ESS,Renuse S,Fernández-Del-Río L,Lu YW,Khalimonchuk O,Clarke CF,Pandey A,Wolfgang MJ,Claypool SM
459600 was used in Western Blot to highlight the multiple ways that SFXN1-based amino acid transport impacts mitochondrial and cellular metabolic efficiency.
Tue Mar 16 00:00:00 UTC 2021
The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.
Cell reports
Acoba MG,Alpergin ESS,Renuse S,Fernández-Del-Río L,Lu YW,Khalimonchuk O,Clarke CF,Pandey A,Wolfgang MJ,Claypool SM
459600 was used in Western Blot to highlight the multiple ways that SFXN1-based amino acid transport impacts mitochondrial and cellular metabolic efficiency.
Tue Mar 16 00:00:00 UTC 2021
Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor.
BMC biology
Affortit C,Casas F,Ladrech S,Ceccato JC,Bourien J,Coyat C,Puel JL,Lenoir M,Wang J
459600 was used in Immunohistochemistry, Immunocytochemistry to probe the role of p43, a N-terminally truncated and ligand-binding form of the nuclear receptor TRα1, in hearing function and in the maintenance of hearing during aging.
Mon Feb 01 00:00:00 UTC 2021
Exacerbated age-related hearing loss in mice lacking the p43 mitochondrial T3 receptor.
BMC biology
Affortit C,Casas F,Ladrech S,Ceccato JC,Bourien J,Coyat C,Puel JL,Lenoir M,Wang J
459600 was used in Immunohistochemistry, Immunocytochemistry to probe the role of p43, a N-terminally truncated and ligand-binding form of the nuclear receptor TRα1, in hearing function and in the maintenance of hearing during aging.
Mon Feb 01 00:00:00 UTC 2021
Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth.
Cell reports
Sighel D,Notarangelo M,Aibara S,Re A,Ricci G,Guida M,Soldano A,Adami V,Ambrosini C,Broso F,Rosatti EF,Longhi S,Buccarelli M,D'Alessandris QG,Giannetti S,Pacioni S,Ricci-Vitiani L,Rorbach J,Pallini R,Roulland S,Amunts A,Mancini I,Modelska A,Quattrone A
459600 was used in Western Blot to investigate whether inhibition of mitochondrial translation can be exploited for glioblastoma treatment by suppressing glioblastoma stem cells.
Tue Apr 27 00:00:00 UTC 2021
Effects of short-term graded dietary carbohydrate intake on intramuscular and whole body metabolism during moderate-intensity exercise.
Journal of applied physiology (Bethesda, Md. : 1985)
Maunder E,Bradley HE,Deane CS,Hodgson AB,Jones M,Joanisse S,Turner AM,Breen L,Philp A,Wallis GA
459600 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that metabolic responses to steady-state aerobic exercise are somewhat resistant to short-term changes in dietary carbohydrate (CHO) intake within the 5-6.5 g CHO·kg-1·day-1 [46-61% energy intake (EI)] range.
Thu Jul 01 00:00:00 UTC 2021
Adaptive optimization of the OXPHOS assembly line partially compensates lrpprc-dependent mitochondrial translation defects in mice.
Communications biology
Cuillerier A,Ruiz M,Daneault C,Forest A,Rossi J,Vasam G,Cairns G,Cadete V,Des Rosiers C,Burelle Y
459600 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to reveal a complex in vivo network of molecular adjustments involved in preserving mitochondrial integrity in energy consuming organs facing OXPHOS defects.
Thu Aug 19 00:00:00 UTC 2021
Dependence on Autophagy for Autoreactive Memory B Cells in the Development of Pristane-Induced Lupus.
Frontiers in immunology
Jang A,Sharp R,Wang JM,Feng Y,Wang J,Chen M
459600 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to suggest that autophagy is important for the persistence of autoreactive memory B cells, maintenance of autoantibody production, and sustained glomerulonephritis in pristane-induced lupus.
Fri Dec 10 00:00:00 UTC 2021
Overexpression of CERKL Protects Retinal Pigment Epithelium Mitochondria from Oxidative Stress Effects.
Antioxidants (Basel, Switzerland)
García-Arroyo R,Gavaldà-Navarro A,Villarroya F,Marfany G,Mirra S
459600 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to analyze the effect of CERKL overexpression and depletion in vivo and in vitro, focusing on the state of the mitochondrial network under oxidative stress conditions.
Sun Dec 19 00:00:00 UTC 2021
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1) rescues the cellular phenotype of MELAS by inducing homeostatic mechanisms.
Proceedings of the National Academy of Sciences of the United States of America
Aras S,Purandare N,Gladyck S,Somayajulu-Nitu M,Zhang K,Wallace DC,Grossman LI
459600 was used in Western Blot to evaluate the effects of forced expression of MNRR1 on the mitochondrial disease mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes syndrome.
Tue Dec 15 00:00:00 UTC 2020
Scaf1 promotes respiratory supercomplexes and metabolic efficiency in zebrafish.
EMBO reports
García-Poyatos C,Cogliati S,Calvo E,Hernansanz-Agustín P,Lagarrigue S,Magni R,Botos M,Langa X,Amati F,Vázquez J,Mercader N,Enríquez JA
459600 was used in Western Blotting to show supercomplex assembly factor 1 (scaf1) modulates oxidative phosphorylation efficiency and optimizes metabolic resources in Zebrafish.
Fri Jul 03 00:00:00 UTC 2020
A 7-day high-fat, high-calorie diet induces fibre-specific increases in intramuscular triglyceride and perilipin protein expression in human skeletal muscle.
The Journal of physiology
Whytock KL,Parry SA,Turner MC,Woods RM,James LJ,Ferguson RA,Ståhlman M,Borén J,Strauss JA,Cocks M,Wagenmakers AJM,Hulston CJ,Shepherd SO
459600 was used in Immunohistochemistry-immunofluorescence to propose that these adaptations of LDs support IMTG storage and minimise accumulation of lipid metabolites to protect skeletal muscle insulin signalling following 7 days' HFHC diet.
Sun Mar 01 00:00:00 UTC 2020
Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men.
The Journal of physiology
Dollerup OL,Chubanava S,Agerholm M,Søndergård SD,Altıntaş A,Møller AB,Høyer KF,Ringgaard S,Stødkilde-Jørgensen H,Lavery GG,Barrès R,Larsen S,Prats C,Jessen N,Treebak JT
459600 was used in Western Blotting to determine if dietary NR supplementation in middle-aged, obese, insulin-resistant men affects mitochondrial respiration, content and morphology in skeletal muscle.
Sat Feb 01 00:00:00 UTC 2020
Cardiolipin is essential for early embryonic viability and mitochondrial integrity of neurons in mammals.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Kasahara T,Kubota-Sakashita M,Nagatsuka Y,Hirabayashi Y,Hanasaka T,Tohyama K,Kato T
459600 was used in Western Blotting to investigate whether cardiolipin synthase and cardiolipin are essential for mammalian cell development by disrupting the Crls1 gene using mouse models.
Wed Jan 01 00:00:00 UTC 2020
Use of in-gel peroxidase assay for cytochrome c to visualize mitochondrial complexes III and IV.
Biology open
Hara T,Shibata Y,Amagai R,Okado-Matsumoto A
459600 was used in Western Blotting to reveal indirect activity within mitochondrial complexes III and IV by in-gel activity assay for cytochrome c.
Wed Jan 08 00:00:00 UTC 2020
Epilepsy in a melanocyte-lineage mTOR hyperactivation mouse model: A novel epilepsy model.
PloS one
Yang F,Yang L,Wataya-Kaneda M,Teng L,Katayama I
459600 was used in Immunohistochemistry to suggest that a melanocyte-lineage mTOR hyperactivation mouse is a novel animal model of epilepsy.
Mon Apr 27 00:00:00 UTC 2020
Epilepsy in a melanocyte-lineage mTOR hyperactivation mouse model: A novel epilepsy model.
PloS one
Yang F,Yang L,Wataya-Kaneda M,Teng L,Katayama I
459600 was used in Immunohistochemistry to suggest that a melanocyte-lineage mTOR hyperactivation mouse is a novel animal model of epilepsy.
Mon Apr 27 00:00:00 UTC 2020
Epilepsy in a melanocyte-lineage mTOR hyperactivation mouse model: A novel epilepsy model.
PloS one
Yang F,Yang L,Wataya-Kaneda M,Teng L,Katayama I
459600 was used in Immunohistochemistry to suggest that a melanocyte-lineage mTOR hyperactivation mouse is a novel animal model of epilepsy.
Mon Apr 27 00:00:00 UTC 2020
Leigh Syndrome Due to NDUFV1 Mutations Initially Presenting as LBSL.
Genes
Borna NN,Kishita Y,Sakai N,Hamada Y,Kamagata K,Kohda M,Ohtake A,Murayama K,Okazaki Y
459600 was used in Western Blotting to describe a case with infantile-onset neurodegeneration, psychomotor retardation, irritability, hypotonia, and nystagmus.
Mon Nov 09 00:00:00 UTC 2020
Leigh Syndrome Due to NDUFV1 Mutations Initially Presenting as LBSL.
Genes
Borna NN,Kishita Y,Sakai N,Hamada Y,Kamagata K,Kohda M,Ohtake A,Murayama K,Okazaki Y
459600 was used in Western Blotting to describe a case with infantile-onset neurodegeneration, psychomotor retardation, irritability, hypotonia, and nystagmus.
Mon Nov 09 00:00:00 UTC 2020
A novel homozygous variant in MICOS13/QIL1 causes hepato-encephalopathy with mitochondrial DNA depletion syndrome.
Molecular genetics & genomic medicine
Kishita Y,Shimura M,Kohda M,Akita M,Imai-Okazaki A,Yatsuka Y,Nakajima Y,Ito T,Ohtake A,Murayama K,Okazaki Y
459600 was used in Western Blotting to determine the clinical significance of the identified variant.
Thu Oct 01 00:00:00 UTC 2020
Isolation of Rab5-positive endosomes reveals a new mitochondrial degradation pathway utilized by BNIP3 and Parkin.
Small GTPases
Hammerling BC,Shires SE,Leon LJ,Cortez MQ,Gustafsson ÅB
459600 was used in Immunocytochemistry to isolate Rab5-positive vesicles from cells for proteomics analysis and provide additional data confirming that mitophagy regulators and mitochondrial proteins are present in these vesicles.
Wed Jan 01 00:00:00 UTC 2020
Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology.
Nature communications
Elouej S,Harhouri K,Le Mao M,Baujat G,Nampoothiri S,Kayserili H,Menabawy NA,Selim L,Paneque AL,Kubisch C,Lessel D,Rubinsztajn R,Charar C,Bartoli C,Airault C,Deleuze JF,Rötig A,Bauer P,Pereira C,Loh A,Escande-Beillard N,Muchir A,Martino L,Gruenbaum Y,Lee SH,Manivet P,Lenaers G,Reversade B,Lévy N,De Sandre-Giovannoli A
459600 was used in Western Blotting to report five homozygous null mutations in MTX2.
Fri Sep 11 00:00:00 UTC 2020
Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology.
Nature communications
Elouej S,Harhouri K,Le Mao M,Baujat G,Nampoothiri S,Kayserili H,Menabawy NA,Selim L,Paneque AL,Kubisch C,Lessel D,Rubinsztajn R,Charar C,Bartoli C,Airault C,Deleuze JF,Rötig A,Bauer P,Pereira C,Loh A,Escande-Beillard N,Muchir A,Martino L,Gruenbaum Y,Lee SH,Manivet P,Lenaers G,Reversade B,Lévy N,De Sandre-Giovannoli A
459600 was used in Western Blotting to report five homozygous null mutations in MTX2.
Fri Sep 11 00:00:00 UTC 2020
Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I.
Cell reports
Formosa LE,Muellner-Wong L,Reljic B,Sharpe AJ,Jackson TD,Beilharz TH,Stojanovski D,Lazarou M,Stroud DA,Ryan MT
459600 was used in Western Blotting to provide new functional insights into the essential nature of the MCIA complex in complex I assembly.
Tue Apr 21 00:00:00 UTC 2020
Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice.
Cell metabolism
Polyzos AA,Lee DY,Datta R,Hauser M,Budworth H,Holt A,Mihalik S,Goldschmidt P,Frankel K,Trego K,Bennett MJ,Vockley J,Xu K,Gratton E,McMurray CT
459600 was used in Western Blotting to show that region-specific neuronal vulnerability is a substrate-driven response in astrocytes.
Tue Jun 04 00:00:00 UTC 2019
Prolonged inhibition and incomplete recovery of mitochondrial function in oxazolidinone-treated megakaryoblastic cell lines.
International journal of antimicrobial agents
Milosevic TV,Vertenoeil G,Payen VL,Sonveaux P,Tulkens PM,Constantinescu SN,Van Bambeke F
459600 was used in Western Blot to explain why oxazolidinone-induced thrombocytopenia is one of the most common side effects in patients exposed to these antibiotics.
Fri Nov 01 00:00:00 UTC 2019
Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.
EMBO molecular medicine
Sprenger HG,Wani G,Hesseling A,König T,Patron M,MacVicar T,Ahola S,Wai T,Barth E,Rugarli EI,Bergami M,Langer T
459600 was used in Western Blotting to report on cell-type-specific defects in mice lacking YME1L in the nervous system.
Tue Jan 01 00:00:00 UTC 2019
A Nonsense Mitochondrial DNA Mutation Associates with Dysfunction of HIF1α in a Von Hippel-Lindau Renal Oncocytoma.
Oxidative medicine and cellular longevity
De Luise M,Guarnieri V,Ceccarelli C,D'Agruma L,Porcelli AM,Gasparre G
459600 was used in Immunohistochemistry to propose that the protumorigenic role of HIF1α in VHL cancers may be blunted through drugs inhibiting mitochondrial respiratory complexes, such as metformin.
Mon Mar 04 00:00:00 UTC 2019
Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications.
Biochimica et biophysica acta. Gene regulatory mechanisms
Choi S,Pfleger J,Jeon YH,Yang Z,He M,Shin H,Sayed D,Astrof S,Abdellatif M
459600 was used in Western Blotting to reveal that select metabolic enzymes are assembled at active, H2A.Z-occupied, promoters, for potential site-directed production of metabolic intermediates that are required for histone modifications.
Tue Oct 01 00:00:00 UTC 2019
Global brain ischemia in rats is associated with mitochondrial release and downregulation of Mfn2 in the cerebral cortex, but not the hippocampus.
International journal of molecular medicine
Klacanova K,Kovalska M,Chomova M,Pilchova I,Tatarkova Z,Kaplan P,Racay P
459600 was used in Western Blotting to study the impact of transient global brain ischemia on the expression of selected proteins involved in mitochondrial dynamics.
Sat Jun 01 00:00:00 UTC 2019
Fluorescent Tissue Assessment of Colorectal Cancer Liver Metastases Ablation Zone: A Potential Real-Time Biomarker of Complete Tumor Ablation.
Annals of surgical oncology
Sotirchos VS,Fujisawa S,Vakiani E,Solomon SB,Manova-Todorova KO,Sofocleous CT
459600 was used in Immunohistochemistry to study whether rapid fluorescent tissue examination immediately after colorectal cancer liver metastasis ablation correlates with standard pathologic and immunohistochemical assessment.
Sat Jun 01 00:00:00 UTC 2019
Mutations in the mitochondrial complex I assembly factor NDUFAF6 cause isolated bilateral striatal necrosis and progressive dystonia in childhood.
Molecular genetics and metabolism
Baide-Mairena H,Gaudó P,Marti-Sánchez L,Emperador S,Sánchez-Montanez A,Alonso-Luengo O,Correa M,Grau AM,Ortigoza-Escobar JD,Artuch R,Vázquez E,Del Toro M,Garrido-Pérez N,Ruiz-Pesini E,Montoya J,Bayona-Bafaluy MP,Pérez-Dueñas B
459600 was used in Western Blot to perform a deep phenotype characterisation in a pedigree of 3 siblings with Leigh syndrome and compound heterozygous NDUFAF6 mutations.
Fri Mar 01 00:00:00 UTC 2019
IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation.
Biochimica et biophysica acta. General subjects
Nadeau L,Patten DA,Caron A,Garneau L,Pinault-Masson E,Foretz M,Haddad P,Anderson BG,Quinn LS,Jardine K,McBurney MW,Pistilli EE,Harper ME,Aguer C
459600 was used in Western Blotting to investigate the role of IL-15 on autocrine/paracrine regulation of muscle glucose uptake and mitochondrial exposure.
Fri Feb 01 00:00:00 UTC 2019
SR Ca2+ leak in skeletal muscle fibers acts as an intracellular signal to increase fatigue resistance.
The Journal of general physiology
Ivarsson N,Mattsson CM,Cheng AJ,Bruton JD,Ekblom B,Lanner JT,Westerblad H
459600 was used in Western Blotting to show muscle fatigue resistance is supported by a signaling pathway triggered by mild ryanodine receptor 1 sarcoplasmic reticulum Ca2+ leak.
Mon Apr 01 00:00:00 UTC 2019
Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response.
Nature communications
Haberman Y,Karns R,Dexheimer PJ,Schirmer M,Somekh J,Jurickova I,Braun T,Novak E,Bauman L,Collins MH,Mo A,Rosen MJ,Bonkowski E,Gotman N,Marquis A,Nistel M,Rufo PA,Baker SS,Sauer CG,Markowitz J,Pfefferkorn MD,Rosh JR,Boyle BM,Mack DR,Baldassano RN,Shah S,Leleiko NS,Heyman MB,Grifiths AM,Patel AS,Noe JD,Aronow BJ,Kugathasan S,Walters TD,Gibson G,Thomas SD,Mollen K,Shen-Orr S,Huttenhower C,Xavier RJ,Hyams JS,Denson LA
459600 was used in Immunohistochemistry to provide insights into UC pathogenesis, and may prioritise future therapies for nonresponders to current approaches.
Thu Jan 03 00:00:00 UTC 2019
Liver Macrophage Depletion Ameliorates The Effect of Mesenchymal Stem Cell Transplantation in a Murine Model of Injured Liver.
Scientific reports
Ghanem LY,Mansour IM,Abulata N,Akl MM,Demerdash ZA,El Baz HG,Mahmoud SS,Mohamed SH,Mahmoud FS,Hassan ASM
Published figure using MTCO1 monoclonal antibody (Product # 459600) in Immunohistochemistry
Thu Jan 10 00:00:00 UTC 2019
The Circadian Protein Nocturnin Regulates Metabolic Adaptation in Brown Adipose Tissue.
iScience
Onder Y,Laothamatas I,Berto S,Sewart K,Kilaru G,Bordieanu B,Stubblefield JJ,Konopka G,Mishra P,Green CB
459600 was used in Western Blotting to study the role of Nocturnin in regulating the transcriptional response and downstream metabolic adaptations during cold exposure in brown adipose tissue.
Fri Sep 27 00:00:00 UTC 2019
Parkin does not prevent accelerated cardiac aging in mitochondrial DNA mutator mice.
JCI insight
Woodall BP,Orogo AM,Najor RH,Cortez MQ,Moreno ER,Wang H,Divakaruni AS,Murphy AN,Gustafsson ÅB
459600 was used in Immunohistochemistry-immunofluorescence to examine the role of Parkin in the context of mitochondrial DNA (mtDNA) damage and myocardial aging using a mouse model carrying a proofreading-defective mtDNA polymerase γ (POLG).
Tue Apr 16 00:00:00 UTC 2019
Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse.
Science advances
Filograna R,Koolmeister C,Upadhyay M,Pajak A,Clemente P,Wibom R,Simard ML,Wredenberg A,Freyer C,Stewart JB,Larsson NG
459600 was used in Western Blot to study to what extent the levels of wild type heteroplasmic mtDNA influence disease manifestations.
Mon Apr 01 00:00:00 UTC 2019
COX6A2 variants cause a muscle-specific cytochrome c oxidase deficiency.
Annals of neurology
Inoue M,Uchino S,Iida A,Noguchi S,Hayashi S,Takahashi T,Fujii K,Komaki H,Takeshita E,Nonaka I,Okada Y,Yoshizawa T,Van Lommel L,Schuit F,Goto YI,Mimaki M,Nishino I
459600 was used in Blue native polyacrylamide gel electrophoresis to indicate that biallelic variants in COX6A2 cause a striated muscle-specific form of COX deficiency.
Thu Aug 01 00:00:00 UTC 2019
Vacuolar H+-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling.
Cells
Son SW,Chau GC,Kim ST,Um SH
459600 was used in Immunocytochemistry to examine the role of ATP7B0C in glucose metabolism in esophageal cancer cells.
Tue Sep 24 00:00:00 UTC 2019
Vacuolar H+-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling.
Cells
Son SW,Chau GC,Kim ST,Um SH
459600 was used in Immunocytochemistry to examine the role of ATP7B0C in glucose metabolism in esophageal cancer cells.
Tue Sep 24 00:00:00 UTC 2019
NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells.
Cell reports
Gupta SS,Sharp R,Hofferek C,Kuai L,Dorn GW,Wang J,Chen M
459600 was used in Immunocytochemistry to suggest that NIX-mediated mitophagy is critical for effector memory formation in T cells.
Tue Nov 12 00:00:00 UTC 2019
SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1.
Molecular metabolism
Sebaa R,Johnson J,Pileggi C,Norgren M,Xuan J,Sai Y,Tong Q,Krystkowiak I,Bondy-Chorney E,Davey NE,Krogan N,Downey M,Harper ME
459600 was used in Western Blotting to study the functional connection between UCP1 and sirturin 3.
Mon Jul 01 00:00:00 UTC 2019
Parkin is a disease modifier in the mutant SOD1 mouse model of ALS.
EMBO molecular medicine
Palomo GM,Granatiero V,Kawamata H,Konrad C,Kim M,Arreguin AJ,Zhao D,Milner TA,Manfredi G
Published figure using COX4 monoclonal antibody (Product # 459600) in Western Blot
Mon Oct 01 00:00:00 UTC 2018
PARL partitions the lipid transfer protein STARD7 between the cytosol and mitochondria.
The EMBO journal
Saita S,Tatsuta T,Lampe PA,König T,Ohba Y,Langer T
Published figure using MTCO1 monoclonal antibody (Product # 459600) in Western Blot
Thu Feb 15 00:00:00 UTC 2018
CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis.
EMBO reports
Becker C,Kukat A,Szczepanowska K,Hermans S,Senft K,Brandscheid CP,Maiti P,Trifunovic A
459600 was used in Western Blotting to establish that loss of the mitochondrial matrix protease CLPP results in a lean phenotype with improved glucose homeostasis.
Tue May 01 00:00:00 UTC 2018
Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism, and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically Relevant Concentrations in Cultured Human HL-60 Promyelocytes and THP-1 Monocytes.
Antimicrobial agents and chemotherapy
Milosevic TV,Payen VL,Sonveaux P,Muccioli GG,Tulkens PM,Van Bambeke F
459600 was used in Western Blotting to compare linezolid and tedizolid for (i) inhibition of the expression of subunit I of cytochrome c-oxidase, (ii) cytochrome c-oxidase activity, (iii) mitochondrial oxidative metabolism, and (iv) alteration of mitochondrial ultrastructure using HL-60 promyelocytes and THP-1 monocytes exposed to microbiologically and therapeutically pertinent concentrations.
Thu Mar 01 00:00:00 UTC 2018
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts.
Nature communications
Torralba D,Baixauli F,Villarroya-Beltri C,Fernández-Delgado I,Latorre-Pellicer A,Acín-Pérez R,Martín-Cófreces NB,Jaso-Tamame ÁL,Iborra S,Jorge I,González-Aseguinolaza G,Garaude J,Vicente-Manzanares M,Enríquez JA,Mittelbrunn M,Sánchez-Madrid F
Published figure using COX4 monoclonal antibody (Product # 459600) in Western Blot
Mon Jul 09 00:00:00 UTC 2018
The phenotype of peritoneal mouse macrophages depends on the mitochondria and ATP/ADP homeostasis.
Cellular immunology
Chen W,Sandoval H,Kubiak JZ,Li XC,Ghobrial RM,Kloc M
459600 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to conclude that the maintenance of mouse macrophage phenotypes depends on mitochondrial function and ATP/ADP homeostasis.
Thu Feb 01 00:00:00 UTC 2018
Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARγ-UCP2-AMPK axis.
Scientific reports
Boutoual R,Meseguer S,Villarroya M,Martín-Hernández E,Errami M,Martín MA,Casado M,Armengod ME
459600 was used in Western Blotting to provide new and useful information on the molecular basis of the MTO1 and GTPBP3 defects and on putative targets for therapeutic intervention.
Thu Jan 18 00:00:00 UTC 2018
Programmed mitophagy is essential for the glycolytic switch during cell differentiation.
The EMBO journal
Esteban-Martínez L,Sierra-Filardi E,McGreal RS,Salazar-Roa M,Mariño G,Seco E,Durand S,Enot D,Graña O,Malumbres M,Cvekl A,Cuervo AM,Kroemer G,Boya P
Published figure using MTCO1 monoclonal antibody (Product # 459600) in Immunofluorescence
Wed Jun 14 00:00:00 UTC 2017
Sixty years old is the breakpoint of human frontal cortex aging.
Free radical biology & medicine
Cabré R,Naudí A,Dominguez-Gonzalez M,Ayala V,Jové M,Mota-Martorell N,Piñol-Ripoll G,Gil-Villar MP,Rué M,Portero-Otín M,Ferrer I,Pamplona R
459600 was used in western blot to discover that protein oxidative and glycoxidative damage significantly increases during human brain aging
Wed Feb 01 00:00:00 UTC 2017
Differential Alterations of the Mitochondrial Morphology and Respiratory Chain Complexes during Postnatal Development of the Mouse Lung.
Oxidative medicine and cellular longevity
El-Merhie N,Baumgart-Vogt E,Pilatz A,Pfreimer S,Pfeiffer B,Pak O,Kosanovic D,Seimetz M,Schermuly RT,Weissmann N,Karnati S
Published figure using COX4 monoclonal antibody (Product # 459600) in Western Blot
Thu Aug 09 00:00:00 UTC 2018
Dietary nitrate markedly improves voluntary running in mice.
Physiology & behavior
Ivarsson N,Schiffer TA,Hernández A,Lanner JT,Weitzberg E,Lundberg JO,Westerblad H
459600 was used in western blot to test if increased submaximal force induced by nitrate supplementation reduces the effort of submaximal voluntary running
Sun Jan 01 00:00:00 UTC 2017
CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart.
PLoS genetics
Gomez-Velazquez M,Badia-Careaga C,Lechuga-Vieco AV,Nieto-Arellano R,Tena JJ,Rollan I,Alvarez A,Torroja C,Caceres EF,Roy AR,Galjart N,Delgado-Olguin P,Sanchez-Cabo F,Enriquez JA,Gomez-Skarmeta JL,Manzanares M
Published figure using COX4 monoclonal antibody (Product # 459600) in Western Blot
Tue Aug 01 00:00:00 UTC 2017
Phagocytosis-dependent ketogenesis in retinal pigment epithelium.
The Journal of biological chemistry
Reyes-Reveles J,Dhingra A,Alexander D,Bragin A,Philp NJ,Boesze-Battaglia K
459600 was used in Immunohistochemistry-immunofluorescence to study the relationship between outer segment phagocytosis and ketogenesis.
Fri May 12 00:00:00 UTC 2017
A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance.
Nature communications
Hammerling BC,Najor RH,Cortez MQ,Shires SE,Leon LJ,Gonzalez ER,Boassa D,Phan S,Thor A,Jimenez RE,Li H,Kitsis RN,Dorn GW,Sadoshima J,Ellisman MH,Gustafsson ÅB
459600 was used in immunocytochemistry to elucidate a novel pathway for mitochondrial elimination, in which these organelles undergo Parkin-dependent sequestration into Rab5-positive early endosomes via the ESCRT machinery
Mon Jan 30 00:00:00 UTC 2017
CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis.
EMBO molecular medicine
Genin EC,Plutino M,Bannwarth S,Villa E,Cisneros-Barroso E,Roy M,Ortega-Vila B,Fragaki K,Lespinasse F,Pinero-Martos E,Augé G,Moore D,Burté F,Lacas-Gervais S,Kageyama Y,Itoh K,Yu-Wai-Man P,Sesaki H,Ricci JE,Vives-Bauza C,Paquis-Flucklinger V
Published figure using MTCO1 monoclonal antibody (Product # 459600) in Western Blot
Fri Jan 01 00:00:00 UTC 2016
Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt.
EMBO reports
Seiferling D,Szczepanowska K,Becker C,Senft K,Hermans S,Maiti P,König T,Kukat A,Trifunovic A
459600 was used in western blot to study the alleviation of mitochondrial cardiomyopathy without affecting the mammalian UPRmt due to loss of CLPP
Fri Jul 01 00:00:00 UTC 2016
Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.
The Journal of cell biology
Korwitz A,Merkwirth C,Richter-Dennerlein R,Tröder SE,Sprenger HG,Quirós PM,López-Otín C,Rugarli EI,Langer T
459600 was used in western blot to analyze delay of neurodegeneration by preventing stress-induced OPA1 processing in mitochondria by loss of OMA1
Mon Jan 18 00:00:00 UTC 2016
Twinkle overexpression prevents cardiac rupture after myocardial infarction by alleviating impaired mitochondrial biogenesis.
American journal of physiology. Heart and circulatory physiology
Inoue T,Ikeda M,Ide T,Fujino T,Matsuo Y,Arai S,Saku K,Sunagawa K
459600 was used in western blot to study alleviation of impaired mitochondrial biogenesis by twinkle overexpression preventing cardiac rupture after myocardial infarction
Thu Sep 01 00:00:00 UTC 2016
PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease.
Human molecular genetics
Martín-Maestro P,Gargini R,Perry G,Avila J,García-Escudero V
Published figure using COX4 monoclonal antibody (Product # 459600) in Immunofluorescence
Mon Feb 15 00:00:00 UTC 2016
Effects of ezrin knockdown on the structure of gastric glandular epithelia.
The journal of physiological sciences : JPS
Yoshida S,Yamamoto H,Tetsui T,Kobayakawa Y,Hatano R,Mukaisho K,Hattori T,Sugihara H,Asano S
459600 was used in immunohistochemistry - paraffin section to demonstrate that a lack of ezrin causes achlorhydria and hypergastrinemia
Fri Jan 01 00:00:00 UTC 2016
Downstream effects of plectin mutations in epidermolysis bullosa simplex with muscular dystrophy.
Acta neuropathologica communications
Winter L,Türk M,Harter PN,Mittelbronn M,Kornblum C,Norwood F,Jungbluth H,Thiel CT,Schlötzer-Schrehardt U,Schröder R
459600 was used in immunohistochemistry - frozen section to study muscular dystrophy and the downstream effects of plectin mutations in epidermolysis bullosa simplex
Wed Apr 27 00:00:00 UTC 2016
The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying.
PLoS genetics
Wang S,Jacquemyn J,Murru S,Martinelli P,Barth E,Langer T,Niessen CM,Rugarli EI
459600 was used in immunohistochemistry - free floating to clarify the role of m-AAA protease in adult glial cells
Thu Dec 01 00:00:00 UTC 2016
MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells.
The Journal of biological chemistry
Vanderperre B,Cermakova K,Escoffier J,Kaba M,Bender T,Nef S,Martinou JC
459600 was used in immunohistochemistry - frozen section to study placental mammal-specific mitochondrial pyruvate carrier subunit called MPC1-like and its expression in post-meiotic male germ cells
Fri Aug 05 00:00:00 UTC 2016
MPC1-like Is a Placental Mammal-specific Mitochondrial Pyruvate Carrier Subunit Expressed in Postmeiotic Male Germ Cells.
The Journal of biological chemistry
Vanderperre B,Cermakova K,Escoffier J,Kaba M,Bender T,Nef S,Martinou JC
459600 was used in immunohistochemistry - frozen section to study placental mammal-specific mitochondrial pyruvate carrier subunit called MPC1-like and its expression in post-meiotic male germ cells
Fri Aug 05 00:00:00 UTC 2016
Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria.
Physiological reports
Strauss JA,Shaw CS,Bradley H,Wilson OJ,Dorval T,Pilling J,Wagenmakers AJ
459600 was used in immunohistochemistry - frozen section to study SNAP23 and colocalization with lipid droplets, mitochondria, and plasma membrane in human skeletal muscle by immunofluorescence microscopy
Fri Jan 01 00:00:00 UTC 2016
Immunofluorescence microscopy of SNAP23 in human skeletal muscle reveals colocalization with plasma membrane, lipid droplets, and mitochondria.
Physiological reports
Strauss JA,Shaw CS,Bradley H,Wilson OJ,Dorval T,Pilling J,Wagenmakers AJ
459600 was used in immunohistochemistry - frozen section to study SNAP23 and colocalization with lipid droplets, mitochondria, and plasma membrane in human skeletal muscle by immunofluorescence microscopy
Fri Jan 01 00:00:00 UTC 2016
A monoclonal antibody raised against bacterially expressed MPV17 sequences shows peroxisomal, endosomal and lysosomal localisation in U2OS cells.
BMC research notes
Weiher H,Pircher H,Jansen-Dürr P,Hegenbarth S,Knolle P,Grunau S,Vapola M,Hiltunen JK,Zwacka RM,Schmelzer E,Reumann K,Will H
459600 was used in immunocytochemistry to study how a monoclonal antibody against bacterially expressed MPV17 sequences show lysosomal, endosomal, and peroxisomal localization in U20S cells
Sat Feb 27 00:00:00 UTC 2016
Cdk2 phosphorylation of Bcl-xL after stress converts it to a pro-apoptotic protein mimicking Bax/Bak.
Cell death discovery
Megyesi J,Tarcsafalvi A,Seng N,Hodeify R,Price PM
459600 was used in western blot to research the conversion to a pro-apoptotic protein mimicking Bax/Bak by Cdk2 phosphorylation of Bcl-xL after stress
Tue Sep 29 00:00:00 UTC 2020
Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids.
Oncotarget
Swiader A,Nahapetyan H,Faccini J,D'Angelo R,Mucher E,Elbaz M,Boya P,Vindis C
459600 was used in western blot to determine the role of mitophagy in apoptosis induced by oxidized low-density lipoproteins using human vascular smooth muscle cells
Tue May 17 00:00:00 UTC 2016
Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice.
Science (New York, N.Y.)
Wai T,García-Prieto J,Baker MJ,Merkwirth C,Benit P,Rustin P,Rupérez FJ,Barbas C,Ibañez B,Langer T
459600 was used in western blot to study how OMA1 links mitochondrial morphology and cardiac metabolism.
Fri Dec 04 00:00:00 UTC 2015
A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity.
Nature cell biology
Monaghan RM,Barnes RG,Fisher K,Andreou T,Rooney N,Poulin GB,Whitmarsh AJ
459600 was used in western blot to study the role of nuclear CLK-1 in regulating mitochondrial stress responses and aging.
Mon Jun 01 00:00:00 UTC 2015
New method to assess mitophagy flux by flow cytometry.
Autophagy
Mauro-Lizcano M,Esteban-Martínez L,Seco E,Serrano-Puebla A,Garcia-Ledo L,Figueiredo-Pereira C,Vieira HL,Boya P
459600 was used in western blot to develop a flow cytometry-based approach to study mitophagy by using MitoTracker Deep Red
Tue Feb 23 00:00:00 UTC 2016
CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans.
PLoS medicine
Martinez-Torres AC,Quiney C,Attout T,Boullet H,Herbi L,Vela L,Barbier S,Chateau D,Chapiro E,Nguyen-Khac F,Davi F,Le Garff-Tavernier M,Moumné R,Sarfati M,Karoyan P,Merle-Béral H,Launay P,Susin SA
459600 was used in western blot to discuss the role of CD47 modulation in treatment of chronic lymphocytic leukemia.
Sun Mar 01 00:00:00 UTC 2015
A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.
The Journal of cell biology
Kumar V,Bouameur JE,Bär J,Rice RH,Hornig-Do HT,Roop DR,Schwarz N,Brodesser S,Thiering S,Leube RE,Wiesner RJ,Vijayaraj P,Brazel CB,Heller S,Binder H,Löffler-Wirth H,Seibel P,Magin TM
Published figure using MTCO1 monoclonal antibody (Product # 459600) in Western Blot
Mon Dec 07 00:00:00 UTC 2015
AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle.
American journal of physiology. Endocrinology and metabolism
Fentz J,Kjøbsted R,Kristensen CM,Hingst JR,Birk JB,Gudiksen A,Foretz M,Schjerling P,Viollet B,Pilegaard H,Wojtaszewski JF
459600 was used in western blot to elucidate the role of AMPKα and -α2 subunits in acute exercise-induced mRNA responses.
Tue Dec 01 00:00:00 UTC 2015
Cyclophilin D, a target for counteracting skeletal muscle dysfunction in mitochondrial myopathy.
Human molecular genetics
Gineste C,Hernandez A,Ivarsson N,Cheng AJ,Naess K,Wibom R,Lesko N,Bruhn H,Wedell A,Freyer C,Zhang SJ,Carlström M,Lanner JT,Andersson DC,Bruton JD,Wredenberg A,Westerblad H
459600 was used in western blot to characterize the effect of cyclosporine A treatment in a mouse model of lethal mitochondrial myopathy.
Tue Dec 01 00:00:00 UTC 2015
Plectin isoform P1b and P1d deficiencies differentially affect mitochondrial morphology and function in skeletal muscle.
Human molecular genetics
Winter L,Kuznetsov AV,Grimm M,Zeöld A,Fischer I,Wiche G
459600 was used in western blot to report how the depletion of distinct plectin isoforms differentially affects mitochondrial network organization and function
Sat Aug 15 00:00:00 UTC 2015
In recurrent primary biliary cirrhosis after liver transplantation, biliary epithelial cells show increased expression of mitochondrial proteins.
Virchows Archiv : an international journal of pathology
Sasaki M,Hsu M,Yeh MM,Nakanuma Y
459600 was used in immunohistochemistry - paraffin section to test if mitochondrial proteins can be used as biomarkers for primary biliary cirrhosis
Thu Oct 01 00:00:00 UTC 2015
Confocal laser endomicroscopy: a new gold standard for the assessment of mucosal healing in ulcerative colitis.
Journal of gastroenterology and hepatology
Macé V,Ahluwalia A,Coron E,Le Rhun M,Boureille A,Bossard C,Mosnier JF,Matysiak-Budnik T,Tarnawski AS
459600 was used in immunohistochemistry - paraffin section to test if endoscopically normal appearing colonic mucosa in patients with UC in remission have fully recovered using confocal laser endomicroscopy
Sun Mar 01 00:00:00 UTC 2015
Exome Sequencing of SLC30A2 Identifies Novel Loss- and Gain-of-Function Variants Associated with Breast Cell Dysfunction.
Journal of mammary gland biology and neoplasia
Alam S,Hennigar SR,Gallagher C,Soybel DI,Kelleher SL
459600 was used in immunocytochemistry to assess the genetic variation of SLC30A2 associated with breast cell dysfunction
Tue Dec 01 00:00:00 UTC 2015
PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes.
PloS one
Kubli DA,Cortez MQ,Moyzis AG,Najor RH,Lee Y,Gustafsson ÅB
459600 was used in immunocytochemistry and western blot to assess the effect of PINK1-deficiency on mitochondrial quality control in myocytes.
Wed Apr 06 00:00:00 UTC 2016
PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes.
PloS one
Kubli DA,Cortez MQ,Moyzis AG,Najor RH,Lee Y,Gustafsson ÅB
459600 was used in immunocytochemistry and western blot to assess the effect of PINK1-deficiency on mitochondrial quality control in myocytes.
Wed Apr 06 00:00:00 UTC 2016
PINK1 Is Dispensable for Mitochondrial Recruitment of Parkin and Activation of Mitophagy in Cardiac Myocytes.
PloS one
Kubli DA,Cortez MQ,Moyzis AG,Najor RH,Lee Y,Gustafsson ÅB
459600 was used in immunocytochemistry and western blot to assess the effect of PINK1-deficiency on mitochondrial quality control in myocytes.
Wed Apr 06 00:00:00 UTC 2016
AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD.
Frontiers in physiology
Brandauer J,Andersen MA,Kellezi H,Risis S,Frøsig C,Vienberg SG,Treebak JT
459600 was used in western blot to test the requirement of AMP-activated protein kinase for exercise training-induced increases in skeletal muscle abundance of mitochondrial proteins.
Wed Apr 08 00:00:00 UTC 2015
Overexpression of TFAM or twinkle increases mtDNA copy number and facilitates cardioprotection associated with limited mitochondrial oxidative stress.
PloS one
Ikeda M,Ide T,Fujino T,Arai S,Saku K,Kakino T,Tyynismaa H,Yamasaki T,Yamada K,Kang D,Suomalainen A,Sunagawa K
459600 was used in western blot to assess the role of mtDNA copy number in heart failure
Tue Feb 23 00:00:00 UTC 2016
Essential role of mitochondrial Ca2+ uniporter in the generation of mitochondrial pH gradient and metabolism-secretion coupling in insulin-releasing cells.
The Journal of biological chemistry
Quan X,Nguyen TT,Choi SK,Xu S,Das R,Cha SK,Kim N,Han J,Wiederkehr A,Wollheim CB,Park KS
459600 was used in western blot to examine the contribution of the mitochondrial Ca(2+) uniporter to the regulation of oxidative phosphorylation and metabolism-secretion coupling in β-cells and rat pancreatic islets.
Fri Feb 13 00:00:00 UTC 2015
Essential role for autophagy in the maintenance of immunological memory against influenza infection.
Nature medicine
Chen M,Hong MJ,Sun H,Wang L,Shi X,Gilbert BE,Corry DB,Kheradmand F,Wang J
459600 was used in immunocytochemistry to study how autophagy in memory B cells regulates vaccine responses
Thu May 01 00:00:00 UTC 2014
Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination.
Nucleic acids research
Robertson AB,Robertson J,Fusser M,Klungland A
459600 was used in western blot to study endonuclease G-mediated cleavage of 5hmC-modified DNA
Mon Dec 01 00:00:00 UTC 2014
Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men.
The Journal of physiology
Olesen J,Gliemann L,Biensø R,Schmidt J,Hellsten Y,Pilegaard H
459600 was used in western blot to compare the effect of exercise training and resveratrol treatment on metabolic and inflammatory status in skeletal muscle of aged men
Tue Apr 15 00:00:00 UTC 2014
Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men.
The Journal of physiology
Olesen J,Gliemann L,Biensø R,Schmidt J,Hellsten Y,Pilegaard H
459600 was used in western blot to compare the effect of exercise training and resveratrol treatment on metabolic and inflammatory status in skeletal muscle of aged men
Tue Apr 15 00:00:00 UTC 2014
GRAF1a is a brain-specific protein that promotes lipid droplet clustering and growth, and is enriched at lipid droplet junctions.
Journal of cell science
Lucken-Ardjomande Häsler S,Vallis Y,Jolin HE,McKenzie AN,McMahon HT
459600 was used in immunocytochemistry to study GRAF1a that promotes lipid droplet clustering and growth and its enrichment at lipid droplet junctions
Sat Nov 01 00:00:00 UTC 2014
Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress.
Journal of bioenergetics and biomembranes
Sanchez-Roman I,Gomez A,Naudí A,Jove M,Gómez J,Lopez-Torres M,Pamplona R,Barja G
459600 was used in western blot to study the effects on rat cardiac mitochondrial oxidative stress of simultaneous treatment with atenolol plus methionine restriction.
Sun Jun 01 00:00:00 UTC 2014
Effects of Roux-en-Y gastric bypass and ileal transposition surgeries on glucose and lipid metabolism in skeletal muscle and liver.
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Pezeshki A,Chelikani PK
459600 was used in western blot to compare the effects of Roux-en Y gastric bypass and ileal transposition surgeries on glucose and lipid metabolism in muscle and liver.
Wed Dec 10 00:00:00 UTC 2014
Ascorbic acid deficiency decreases hepatic cytochrome P-450, especially CYP2B1/2B2, and simultaneously induces heme oxygenase-1 gene expression in scurvy-prone ODS rats.
Bioscience, biotechnology, and biochemistry
Kobayashi M,Hoshinaga Y,Miura N,Tokuda Y,Shigeoka S,Murai A,Horio F
459600 was used in western blot to determine the mechanisms underlying the decrease in hepatic cytochrome P-450 during ascorbic acid deficiency using scurvy-prone ODS rats.
Mon Mar 30 00:00:00 UTC 2015
An MRPS12 mutation modifies aminoglycoside sensitivity caused by 12S rRNA mutations.
Frontiers in genetics
Emperador S,Pacheu-Grau D,Bayona-Bafaluy MP,Garrido-Pérez N,Martín-Navarro A,López-Pérez MJ,Montoya J,Ruiz-Pesini E
459600 was used in western blot to use an evolutionary approach to identify putative modifying factors involved in aminoglycoside-induced and non-syndromic hearing loss.
Mon Feb 02 00:00:00 UTC 2015
Upregulation of mitochondrial Nox4 mediates TGF-β-induced apoptosis in cultured mouse podocytes.
American journal of physiology. Renal physiology
Das R,Xu S,Quan X,Nguyen TT,Kong ID,Chung CH,Lee EY,Cha SK,Park KS
459600 was used in immunocytochemistry to study the role of mitochochondrial Nox4 upregulation in the induction of cultured murine podicyte apoptosis by TGF-beta.
Wed Jan 01 00:00:00 UTC 2014
GRSF1 regulates RNA processing in mitochondrial RNA granules.
Cell metabolism
Jourdain AA,Koppen M,Wydro M,Rodley CD,Lightowlers RN,Chrzanowska-Lightowlers ZM,Martinou JC
459600 was used in western blot to study the localization of a GRSF isoform to the mitochondrial matrix and its role in RNA processing.
Tue Mar 05 00:00:00 UTC 2013
Independent roles of methionine sulfoxide reductase A in mitochondrial ATP synthesis and as antioxidant in retinal pigment epithelial cells.
Free radical biology & medicine
Dun Y,Vargas J,Brot N,Finnemann SC
459600 was used in western blot to test if and how MsrA affects retinal pigment epithelium functionality.
Sun Dec 01 00:00:00 UTC 2013
Sprint interval and traditional endurance training increase net intramuscular triglyceride breakdown and expression of perilipin 2 and 5.
The Journal of physiology
Shepherd SO,Cocks M,Tipton KD,Ranasinghe AM,Barker TA,Burniston JG,Wagenmakers AJ,Shaw CS
459600 was used in immunohistochemistry (frozen) to investigate the effects of endurance training on intramuscular triglyceride utilization.
Fri Feb 01 00:00:00 UTC 2013
Distinct and additive effects of sodium bicarbonate and continuous mild heat stress on fiber type shift via calcineurin/NFAT pathway in human skeletal myoblasts.
American journal of physiology. Cell physiology
Yamaguchi T,Omori M,Tanaka N,Fukui N
459600 was used in immunocytochemistry to examine the effects of NaHCO3 on myogenesis.
Thu Aug 01 00:00:00 UTC 2013
Identification of mitochondrial dysfunction in Hutchinson-Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture.
Journal of proteomics
Rivera-Torres J,Acín-Perez R,Cabezas-Sánchez P,Osorio FG,Gonzalez-Gómez C,Megias D,Cámara C,López-Otín C,Enríquez JA,Luque-García JL,Andrés V
459600 was used in western blot to elucidate the mechanisms underlying cellular damage and senescence and accelerated aging in Hutchinson-Gilford progeria syndrome.
Tue Oct 08 00:00:00 UTC 2013
Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice.
PloS one
Kristensen JM,Larsen S,Helge JW,Dela F,Wojtaszewski JF
459600 was used in western blot to investigate the effect of metformin treatment on mitochondrial respiration in mouse skeletal muscle
Tue Jul 09 00:00:00 UTC 2013
DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE).
PloS one
Shadrach KG,Rayborn ME,Hollyfield JG,Bonilha VL
459600 was used in immunocytochemistry to study oxidative stress in the retinal pigment epithelium (RPE) regulated by DJ-1
Fri Feb 07 00:00:00 UTC 2014
Sprint interval and endurance training are equally effective in increasing muscle microvascular density and eNOS content in sedentary males.
The Journal of physiology
Cocks M,Shaw CS,Shepherd SO,Fisher JP,Ranasinghe AM,Barker TA,Tipton KD,Wagenmakers AJ
459600 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to show that in sedentary males SIT and ET are effective in improving muscle microvascular density and eNOS protein content.
Fri Feb 01 00:00:00 UTC 2013
Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production.
PloS one
Gonon AT,Jung C,Katz A,Westerblad H,Shemyakin A,Sjöquist PO,Lundberg JO,Pernow J
459600 was used in western blot to study arginase in ischemic myocardium.
Mon Jan 14 00:00:00 UTC 2013
Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice.
The Journal of physiology
Yamada T,Ivarsson N,Hernández A,Fahlström A,Cheng AJ,Zhang SJ,Bruton JD,Ulfhake B,Westerblad H
459600 was used in Western Blot to examine the time course of development of muscle dysfunction in a mouse model of premature ageing induced by defective proofreading function of mitochondrial DNA (mtDNA) polymerase (mtDNA mutator mouse).
Sat Dec 01 00:00:00 UTC 2012
EMG-normalised kinase activation during exercise is higher in human gastrocnemius compared to soleus muscle.
PloS one
Jensen TE,Leutert R,Rasmussen ST,Mouatt JR,Christiansen ML,Jensen BR,Richter EA
459600 was used in western blot to study the greater activation of phosphorylation pathways in human gastrocnemius as compared to soleus muscle when normalized for EMG activity.
Tue Jul 31 00:00:00 UTC 2012
Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation.
Cell metabolism
Tucker EJ,Hershman SG,Köhrer C,Belcher-Timme CA,Patel J,Goldberger OA,Christodoulou J,Silberstein JM,McKenzie M,Ryan MT,Compton AG,Jaffe JD,Carr SA,Calvo SE,RajBhandary UL,Thorburn DR,Mootha VK
459600 was used in western blot to test the requirement of formylation for initiation in human mitochondria.
Wed Sep 07 00:00:00 UTC 2011
Mutation in the mitochondrial tRNA(Val) causes mitochondrial encephalopathy, lactic acidosis and stroke-like episodes.
Mitochondrion
Glatz C,D'Aco K,Smith S,Sondheimer N
459600 was used in western blot to study the effects of the m.1630A G mutation in the mitochondrial tRNA gene.
Fri Jul 01 00:00:00 UTC 2011
Role of PGC-1α in exercise and fasting-induced adaptations in mouse liver.
American journal of physiology. Regulatory, integrative and comparative physiology
Haase TN,Ringholm S,Leick L,Biensø RS,Kiilerich K,Johansen S,Nielsen MM,Wojtaszewski JF,Hidalgo J,Pedersen PA,Pilegaard H
459600 was used in western blot to examine the role of PGC-α in fasting.
Tue Nov 01 00:00:00 UTC 2011
Identification of human fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) as a novel mitochondrial acylpyruvase.
The Journal of biological chemistry
Pircher H,Straganz GD,Ehehalt D,Morrow G,Tanguay RM,Jansen-Dürr P
459600 was used in immunocytochemistry to determine the enzymatic function of FAHD1.
Fri Oct 21 00:00:00 UTC 2011
Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses.
DNA repair
Lauritzen KH,Cheng C,Wiksen H,Bergersen LH,Klungland A
459600 was used in immunohistochemistry - paraffin section to investigate the effects of mitochondrial DNA damage on hippocampal neurons.
Fri Jun 10 00:00:00 UTC 2011
The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction.
The Journal of biological chemistry
Dun MD,Smith ND,Baker MA,Lin M,Aitken RJ,Nixon B
459600 was used in western blot to identify molecules involved in sperm-zona pellucida interactions.
Fri Oct 21 00:00:00 UTC 2011
PGC-1{alpha} is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle.
American journal of physiology. Endocrinology and metabolism
Leick L,Fentz J,Biensø RS,Knudsen JG,Jeppesen J,Kiens B,Wojtaszewski JF,Pilegaard H
459600 was used in Western Blotting to provide genetic evidence for a role of PGC-1alpha in AMPK-mediated regulation of mitochondrial and glucose membrane transport protein expression in skeletal muscle.
Wed Sep 01 00:00:00 UTC 2010
Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease.
The American journal of pathology
Brosel S,Yang H,Tanji K,Bonilla E,Schon EA
459600 was used in western blot to examine the tissue distribution of SCO1 and SCO2
Mon Nov 01 00:00:00 UTC 2010
Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease.
The American journal of pathology
Brosel S,Yang H,Tanji K,Bonilla E,Schon EA
459600 was used in western blot to examine the tissue distribution of SCO1 and SCO2
Mon Nov 01 00:00:00 UTC 2010
Bim is the key mediator of glucocorticoid-induced apoptosis and of its potentiation by rapamycin in human myeloma cells.
Biochimica et biophysica acta
López-Royuela N,Balsas P,Galán-Malo P,Anel A,Marzo I,Naval J
459600 was used in western blot to investigate dexamethasone-induced apoptosis
Mon Feb 01 00:00:00 UTC 2010
Identification and characterization of mitochondrial targeting sequence of human apurinic/apyrimidinic endonuclease 1.
The Journal of biological chemistry
Li M,Zhong Z,Zhu J,Xiang D,Dai N,Cao X,Qing Y,Yang Z,Xie J,Li Z,Baugh L,Wang G,Wang D
459600 was used in western blot to study the mitochondrial targeting sequence of apurinic/apyrimidinic endonuclease
Fri May 14 00:00:00 UTC 2010
GDP and carboxyatractylate inhibit 4-hydroxynonenal-activated proton conductance to differing degrees in mitochondria from skeletal muscle and heart.
Biochimica et biophysica acta
Aguirre E,Cadenas S
459600 was used in western blot to investigate the differences of proton conductance mechanism between skeletal muscle and heart
Fri Oct 01 00:00:00 UTC 2010
CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells.
Cell motility and the cytoskeleton
Berryman MA,Goldenring JR
459600 was used in immunocytochemistry to investigate the localization and function of CLIC4
Sat Nov 01 00:00:00 UTC 2003
Mammalian cytochrome-c oxidase: characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells.
Methods in enzymology
Capaldi RA,Marusich MF,Taanman JW
459600 was used in western blot to Mammalian cytochrome-c oxidase: characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells
Mon Apr 01 00:00:00 UTC 1996
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.jpg?time=20250104?time=20250104 "MTCO1 Antibody (459600) in WB")
