Product References
AKT-driven epithelial-mesenchymal transition is affected by copper bioavailability in HER2 negative breast cancer cells via a LOXL2-independent mechanism.
Cellular oncology (Dordrecht, Netherlands)
Vitaliti A,Roccatani I,Iorio E,Perta N,Gismondi A,Chirico M,Pisanu ME,Di Marino D,Canini A,De Luca A,Rossi L
A-6404 was used in Western Blotting to support the use of copper-chelators as an adjuvant therapeutic strategy for TNBC.
Wed Feb 01 00:00:00 UTC 2023
Increased Expression of the Mitochondrial Glucocorticoid Receptor Enhances Tumor Aggressiveness in a Mouse Xenograft Model.
International journal of molecular sciences
Karra AG,Tsialtas I,Kalousi FD,Georgantopoulos A,Sereti E,Dimas K,Psarra AG
A-6404 was used in Western Blot to propose that increased mitochondrial localization of mtGR is associated with tumor progression possible via mtGR/PDH interaction, which could lead to suppression of PDH activity and modulation of mtGR-induced mitochondrial transcription that ends up in reduced OXPHOS biosynthesis and reduced oxidative phosphorylation versus glycolytic pathway energy production, in favor of cancer cells.
Mon Feb 13 00:00:00 UTC 2023
Low-dose of caffeine alleviates high altitude pulmonary edema via regulating mitochondrial quality control process in AT1 cells.
Frontiers in pharmacology
Tian L,Jia Z,Yan Y,Jia Q,Shi W,Cui S,Chen H,Han Y,Zhao X,He K
A-6404 was used in Immunocytochemistry to find that caffeine blocked the reduction of ATP production and oxygen consumption rate, decreased ROS accumulation, and stabilized mitochondrial membrane potential to protect AT1 cells from oxidative stress damage under hypoxia.
Sat Apr 22 00:00:00 UTC 2023
Subcutaneous adipose tissue sclerostin is reduced and Wnt signaling is enhanced following 4-weeks of sprint interval training in young men with obesity.
Physiological reports
Kurgan N,Islam H,Matusiak JBL,Baranowski BJ,Stoikos J,Fajardo VA,MacPherson REK,Gurd BJ,Klentrou P
A-6404 was used in Western Blotting to examine subcutaneous WAT (scWAT) sclerostin content and Wnt signaling in response to exercise training in young men with obesity.
Tue Mar 01 00:00:00 UTC 2022
Aristolochic acid I induces proximal tubule injury through ROS/HMGB1/mt DNA mediated activation of TLRs.
Journal of cellular and molecular medicine
Upadhyay R,Batuman V
A-6404 was used in Immunocytochemistry, Western Blot to show that aristolochic acid I treatment causes injury to proximal tubule cells through ROS-HMGB1/mitochondrial DNA (mt DNA)-mediated activation of TLRs and inflammatory response.
Mon Aug 01 00:00:00 UTC 2022
The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.
Cell reports
Acoba MG,Alpergin ESS,Renuse S,Fernández-Del-Río L,Lu YW,Khalimonchuk O,Clarke CF,Pandey A,Wolfgang MJ,Claypool SM
A-6404 was used in Western Blot to highlight the multiple ways that SFXN1-based amino acid transport impacts mitochondrial and cellular metabolic efficiency.
Tue Mar 16 00:00:00 UTC 2021
The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.
Cell reports
Acoba MG,Alpergin ESS,Renuse S,Fernández-Del-Río L,Lu YW,Khalimonchuk O,Clarke CF,Pandey A,Wolfgang MJ,Claypool SM
A-6404 was used in Western Blot to highlight the multiple ways that SFXN1-based amino acid transport impacts mitochondrial and cellular metabolic efficiency.
Tue Mar 16 00:00:00 UTC 2021
SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells.
Cell reports
Mason JA,Cockfield JA,Pape DJ,Meissner H,Sokolowski MT,White TC,Valentín López JC,Liu J,Liu X,Martínez-Reyes I,Chandel NS,Locasale JW,Schafer ZT
A-6404 was used in Western Blot to show SGK1 as master regulator of glucose metabolism and cell survival during ECM-detached conditions.
Tue Mar 16 00:00:00 UTC 2021
Arsenic Stimulates Myoblast Mitochondrial Epidermal Growth Factor Receptor to Impair Myogenesis.
Toxicological sciences : an official journal of the Society of Toxicology
Cheikhi A,Anguiano T,Lasak J,Qian B,Sahu A,Mimiya H,Cohen CC,Wipf P,Ambrosio F,Barchowsky A
A-6404 was used in Immunocytochemistry to conclude that arsenic-driven pathogenesis in skeletal muscle requires sustained mitochondrial EGFR activation that promotes progenitor cell cycling and proliferation at the detriment of proper differentiation.
Wed Jul 01 00:00:00 UTC 2020
Differential Expression of ADP/ATP Carriers as a Biomarker of Metabolic Remodeling and Survival in Kidney Cancers.
Biomolecules
Trisolini L,Laera L,Favia M,Muscella A,Castegna A,Pesce V,Guerra L,De Grassi A,Volpicella M,Pierri CL
A-6404 was used in Western Blotting to study ADP/ATP carriers (AACs) as a new molecular target for cancer treatment.
Wed Dec 30 00:00:00 UTC 2020
Differential Expression of ADP/ATP Carriers as a Biomarker of Metabolic Remodeling and Survival in Kidney Cancers.
Biomolecules
Trisolini L,Laera L,Favia M,Muscella A,Castegna A,Pesce V,Guerra L,De Grassi A,Volpicella M,Pierri CL
A-6404 was used in Western Blotting to study ADP/ATP carriers (AACs) as a new molecular target for cancer treatment.
Wed Dec 30 00:00:00 UTC 2020
MTFMT deficiency correlates with reduced mitochondrial integrity and enhanced host susceptibility to intracellular infection.
Scientific reports
Seo JH,Hwang CS,Yoo JY
A-6404 was used in Western Blotting to suggest that the integrity of mitochondria is essential to their proper function in protecting against infection, as intact mitochondria not only block the release of danger molecules but also serve as signaling hubs for the downstream NF-κB pathway.
Tue Jul 07 00:00:00 UTC 2020
MTFMT deficiency correlates with reduced mitochondrial integrity and enhanced host susceptibility to intracellular infection.
Scientific reports
Seo JH,Hwang CS,Yoo JY
A-6404 was used in Western Blotting to suggest that the integrity of mitochondria is essential to their proper function in protecting against infection, as intact mitochondria not only block the release of danger molecules but also serve as signaling hubs for the downstream NF-κB pathway.
Tue Jul 07 00:00:00 UTC 2020
Mitochondrial Oxidative Phosphorylation Complex Regulates NLRP3 Inflammasome Activation and Predicts Patient Survival in Nasopharyngeal Carcinoma.
Molecular & cellular proteomics : MCP
Chung IC,Chen LC,Tsang NM,Chuang WY,Liao TC,Yuan SN,OuYang CN,Ojcius DM,Wu CC,Chang YS
A-6404 was used in Western Blotting to demonstrate that up-regulated mitochondrial OxPhos components are strongly associated with NLRP3 inflammasome activation in NPC.
Wed Jan 01 00:00:00 UTC 2020
Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I.
Cell reports
Formosa LE,Muellner-Wong L,Reljic B,Sharpe AJ,Jackson TD,Beilharz TH,Stojanovski D,Lazarou M,Stroud DA,Ryan MT
A-6404 was used in Western Blotting to provide new functional insights into the essential nature of the MCIA complex in complex I assembly.
Tue Apr 21 00:00:00 UTC 2020
Lactic acidosis caused by repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the pyruvate dehydrogenase (PDH)-PDH kinase axis.
The Journal of biological chemistry
Hong SM,Lee YK,Park I,Kwon SM,Min S,Yoon G
A-6404 was used in Western Blotting to investigate how lactate dehydrogenase subunit B (LDHB) suppression regulates mitochondrial respiratory activity and contributes to liver cancer progression.
Fri May 10 00:00:00 UTC 2019
Mitochondrial Complex I Activity Is Required for Maximal Autophagy.
Cell reports
Thomas HE,Zhang Y,Stefely JA,Veiga SR,Thomas G,Kozma SC,Mercer CA
A-6404 was used in Western Blotting to reveal the dynamic and metabolic regulation of autophagy.
Tue Aug 28 00:00:00 UTC 2018
Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells.
Nature medicine
Kuntz EM,Baquero P,Michie AM,Dunn K,Tardito S,Holyoake TL,Helgason GV,Gottlieb E
A-6404 was used in Western Blotting to assess the therapeutic potential of targeting mitochondrial oxidative phosphorylation to eradicate therapy-resistant chronic myeloid leukaemia stem cells.
Sun Oct 01 00:00:00 UTC 2017
Differential Alterations of the Mitochondrial Morphology and Respiratory Chain Complexes during Postnatal Development of the Mouse Lung.
Oxidative medicine and cellular longevity
El-Merhie N,Baumgart-Vogt E,Pilatz A,Pfreimer S,Pfeiffer B,Pak O,Kosanovic D,Seimetz M,Schermuly RT,Weissmann N,Karnati S
Published figure using MTCO2 monoclonal antibody (Product # A-6404) in Western Blot
Thu Aug 09 00:00:00 UTC 2018
Differential Alterations of the Mitochondrial Morphology and Respiratory Chain Complexes during Postnatal Development of the Mouse Lung.
Oxidative medicine and cellular longevity
El-Merhie N,Baumgart-Vogt E,Pilatz A,Pfreimer S,Pfeiffer B,Pak O,Kosanovic D,Seimetz M,Schermuly RT,Weissmann N,Karnati S
Published figure using MTCO2 monoclonal antibody (Product # A-6404) in Western Blot
Thu Aug 09 00:00:00 UTC 2018
HIV-1 promonocytic and lymphoid cell lines: an in vitro model of in vivo mitochondrial and apoptotic lesion.
Journal of cellular and molecular medicine
Morén C,González-Casacuberta I,Álvarez-Fernández C,Bañó M,Catalán-Garcia M,Guitart-Mampel M,Juárez-Flores DL,Tobías E,Milisenda J,Cardellach F,Gatell JM,Sánchez-Palomino S,Garrabou G
A6404 was used in western blot to investigate mitochondrial and apoptotic parameters in chronically human immunodeficiency virus-infected promonocytic and lymphoid cells
Wed Feb 01 00:00:00 UTC 2017
Mitochondrial Maturation in Human Pluripotent Stem Cell Derived Cardiomyocytes.
Stem cells international
Dai DF,Danoviz ME,Wiczer B,Laflamme MA,Tian R
A6404 was used in immunocytochemistry to discover the development of mitochondria during prolonged in vitro culturing of human pluripotent stem cells derived cardiomyocytes
Thu Oct 01 00:00:00 UTC 2020
The human RNA-binding protein RBFA promotes the maturation of the mitochondrial ribosome.
The Biochemical journal
Rozanska A,Richter-Dennerlein R,Rorbach J,Gao F,Lewis RJ,Chrzanowska-Lightowlers ZM,Lightowlers RN
A-6404 was used in Western Blotting to examine the roles of ribosome-binding Factor A in mitoribosome biogenesis.
Tue Jun 13 00:00:00 UTC 2017
Human adenine nucleotide translocases physically and functionally interact with respirasomes.
Molecular biology of the cell
Lu YW,Acoba MG,Selvaraju K,Huang TC,Nirujogi RS,Sathe G,Pandey A,Claypool SM
A-6404 was used in Western Blotting to identify that adenine nucleotide translocases (ANTs) and the oxidative phosphorylation machinery physically interact and functionally cooperate to enhance ANT transport capacity and mitochondrial respiration.
Thu Jun 01 00:00:00 UTC 2017
Antiphospholipid antibodies increase the levels of mitochondrial DNA in placental extracellular vesicles: Alarmin-g for preeclampsia.
Scientific reports
Tong M,Johansson C,Xiao F,Stone PR,James JL,Chen Q,Cree LM,Chamley LW
A-6404 was used in Western Blotting to investigate whether antiphospholipid antibodies affect the number of placental vesicles extruded, their mitochondrial DNA content, and their ability to activate endothelial cells.
Wed Nov 29 00:00:00 UTC 2017
Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Nature
Stroud DA,Surgenor EE,Formosa LE,Reljic B,Frazier AE,Dibley MG,Osellame LD,Stait T,Beilharz TH,Thorburn DR,Salim A,Ryan MT
A-6404 was used in western blot to investigate the role of Complex I accessory subunits
Thu Oct 06 00:00:00 UTC 2016
Melanoma addiction to the long non-coding RNA SAMMSON.
Nature
Leucci E,Vendramin R,Spinazzi M,Laurette P,Fiers M,Wouters J,Radaelli E,Eyckerman S,Leonelli C,Vanderheyden K,Rogiers A,Hermans E,Baatsen P,Aerts S,Amant F,Van Aelst S,van den Oord J,de Strooper B,Davidson I,Lafontaine DL,Gevaert K,Vandesompele J,Mestdagh P,Marine JC
A-6404 was used in western blot to study melanoma addiction to RNA SAMMSON long non-coding region
Thu Mar 24 00:00:00 UTC 2016
Heme Oxygenase-1/Carbon Monoxide System and Embryonic Stem Cell Differentiation and Maturation into Cardiomyocytes.
Antioxidants & redox signaling
Suliman HB,Zobi F,Piantadosi CA
A-6404 was used in western blot to assess the impact of the heme oxygenase-1/carbon monoxide system on embryonic stem cell differentiation and cardiomyocyte maturation
Tue Mar 01 00:00:00 UTC 2016
Heme Oxygenase-1/Carbon Monoxide System and Embryonic Stem Cell Differentiation and Maturation into Cardiomyocytes.
Antioxidants & redox signaling
Suliman HB,Zobi F,Piantadosi CA
A-6404 was used in western blot to assess the impact of the heme oxygenase-1/carbon monoxide system on embryonic stem cell differentiation and cardiomyocyte maturation
Tue Mar 01 00:00:00 UTC 2016
Improved adipose tissue function with initiation of protease inhibitor-only ART.
The Journal of antimicrobial chemotherapy
Maughan RT,Feeney ER,Capel E,Capeau J,Domingo P,Giralt M,Lange JM,Phanuphak P,Cooper DA,Reiss P,Mallon PW
A-6404 was used in western blot to assess the effect of initiating PI-only ART on subcutaneous adipose tissue function in ART-naive subjects
Tue Nov 01 00:00:00 UTC 2016
Two different pathogenic mechanisms, dying-back axonal neuropathy and pancreatic senescence, are present in the YG8R mouse model of Friedreich's ataxia.
Disease models & mechanisms
Mollá B,Riveiro F,Bolinches-Amorós A,Muñoz-Lasso DC,Palau F,González-Cabo P
A-6404 was used in western blot to utilize a YG8R mouse model of Friedreich's ataxia that has two different pathogenic mechanisms of pancreatic senescence and dying-back axonal neuropathy
Wed Jun 01 00:00:00 UTC 2016
Disruption of the human COQ5-containing protein complex is associated with diminished coenzyme Q10 levels under two different conditions of mitochondrial energy deficiency.
Biochimica et biophysica acta
Yen HC,Liu YC,Kan CC,Wei HJ,Lee SH,Wei YH,Feng YH,Chen CW,Huang CC
A-6404 was used in western blot to discuss the role of the Coq protein complex to health and disease
Thu Sep 01 00:00:00 UTC 2016
Impaired Muscle Mitochondrial Biogenesis and Myogenesis in Spinal Muscular Atrophy.
JAMA neurology
Ripolone M,Ronchi D,Violano R,Vallejo D,Fagiolari G,Barca E,Lucchini V,Colombo I,Villa L,Berardinelli A,Balottin U,Morandi L,Mora M,Bordoni A,Fortunato F,Corti S,Parisi D,Toscano A,Sciacco M,DiMauro S,Comi GP,Moggio M
Published figure using MTCO2 monoclonal antibody (Product # A-6404) in Western Blot
Mon Jun 01 00:00:00 UTC 2015
Identification of a mitochondrial defect gene signature reveals NUPR1 as a key regulator of liver cancer progression.
Hepatology (Baltimore, Md.)
Lee YK,Jee BA,Kwon SM,Yoon YS,Xu WG,Wang HJ,Wang XW,Thorgeirsson SS,Lee JS,Woo HG,Yoon G
A-6404 was used in western blot to investigate the role of NUPR1 during liver carcinogenesis
Thu Oct 01 00:00:00 UTC 2015
A truncating PET100 variant causing fatal infantile lactic acidosis and isolated cytochrome c oxidase deficiency.
European journal of human genetics : EJHG
Oláhová M,Haack TB,Alston CL,Houghton JA,He L,Morris AA,Brown GK,McFarland R,Chrzanowska-Lightowlers ZM,Lightowlers RN,Prokisch H,Taylor RW
A-6404 was used in western blot to present a case of a patient with isolated mitochondrial complex IV (cytochrome c oxidase) deficiency.
Wed Jul 01 00:00:00 UTC 2015
A truncating PET100 variant causing fatal infantile lactic acidosis and isolated cytochrome c oxidase deficiency.
European journal of human genetics : EJHG
Oláhová M,Haack TB,Alston CL,Houghton JA,He L,Morris AA,Brown GK,McFarland R,Chrzanowska-Lightowlers ZM,Lightowlers RN,Prokisch H,Taylor RW
A-6404 was used in western blot to present a case of a patient with isolated mitochondrial complex IV (cytochrome c oxidase) deficiency.
Wed Jul 01 00:00:00 UTC 2015
TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling.
Breast cancer research and treatment
Sakabe I,Hu R,Jin L,Clarke R,Kasid UN
A-6404 was used in western blot to study the role of transmembrane protein 33 in the unfolded protein response
Tue Sep 01 00:00:00 UTC 2015
Effect of one month duration ketogenic and non-ketogenic high fat diets on mouse brain bioenergetic infrastructure.
Journal of bioenergetics and biomembranes
Selfridge JE,Wilkins HM,E L,Carl SM,Koppel S,Funk E,Fields T,Lu J,Tang EP,Slawson C,Wang W,Zhu H,Swerdlow RH
A-6404 was used in immunohistochemistry - frozen section to study the effect of ketosis-inducing and non-inducing high fat diets on genes and proteins relevant to brain bioenergetic infrastructures
Wed Apr 01 00:00:00 UTC 2015
Effect of one month duration ketogenic and non-ketogenic high fat diets on mouse brain bioenergetic infrastructure.
Journal of bioenergetics and biomembranes
Selfridge JE,Wilkins HM,E L,Carl SM,Koppel S,Funk E,Fields T,Lu J,Tang EP,Slawson C,Wang W,Zhu H,Swerdlow RH
A-6404 was used in immunohistochemistry - frozen section to study the effect of ketosis-inducing and non-inducing high fat diets on genes and proteins relevant to brain bioenergetic infrastructures
Wed Apr 01 00:00:00 UTC 2015
Mitochondrial Respiratory Dysfunction Induces Claudin-1 Expression via Reactive Oxygen Species-mediated Heat Shock Factor 1 Activation, Leading to Hepatoma Cell Invasiveness.
The Journal of biological chemistry
Lee JH,Lee YK,Lim JJ,Byun HO,Park I,Kim GH,Xu WG,Wang HJ,Yoon G
A-6404 was used in western blot to show that mitochondrial respiratory defects contribute to hepatoma invasiveness.
Fri Aug 28 00:00:00 UTC 2015
Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells.
PloS one
Lauková J,Kozubík A,Hofmanová J,Nekvindová J,Sova P,Moyer MP,Ehrmann J,Hyršlová Vaculová A
A-6404 was used in western blot to identify the mechanism for apoptosis in colon cancer cells after depletion of PTEN
Thu Jun 30 00:00:00 UTC 2016
Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier.
PloS one
Martínez-Zamora A,Meseguer S,Esteve JM,Villarroya M,Aguado C,Enríquez JA,Knecht E,Armengod ME
A-6404 was used in western blot to analyze GTPBP3 defective expression in AMPK-mediated responses
Mon Jun 27 00:00:00 UTC 2016
Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency.
EMBO molecular medicine
Garone C,Garcia-Diaz B,Emmanuele V,Lopez LC,Tadesse S,Akman HO,Tanji K,Quinzii CM,Hirano M
A-6404 was used in immunohistochemistry - paraffin section to study thymidine kinase 2 deficiency and therapy from deoxypyrimidine monophosphate
Fri Aug 01 00:00:00 UTC 2014
Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington's disease knock-in striatal cells.
Free radical biology & medicine
Ribeiro M,Rosenstock TR,Oliveira AM,Oliveira CR,Rego AC
A-6404 was used in western blot to examine the role of insulin and IGF-1 on the mitochondria of striatal cells derived from HD knock-in mice.
Mon Sep 01 00:00:00 UTC 2014
Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wolff NA,Ghio AJ,Garrick LM,Garrick MD,Zhao L,Fenton RA,Thévenod F
A-6404 was used in western blot to study iron transport into mitochondria.
Thu May 01 00:00:00 UTC 2014
Glycogen synthase kinase-3 (GSK3) controls deoxyglucose-induced mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells.
Mitochondrion
Ngamsiri P,Watcharasit P,Satayavivad J
A-6404 was used in western blot to study the effect of SB216763 on mitochondrial biogenesis
Wed Jan 01 00:00:00 UTC 2014
Mutation of the human mitochondrial phenylalanine-tRNA synthetase causes infantile-onset epilepsy and cytochrome c oxidase deficiency.
Biochimica et biophysica acta
Almalki A,Alston CL,Parker A,Simonic I,Mehta SG,He L,Reza M,Oliveira JM,Lightowlers RN,McFarland R,Taylor RW,Chrzanowska-Lightowlers ZM
A-6404 was used in western blot to identify and investigate a FARS2 mutation in a patient with early-onset epilepsy and isolated complex IV deficiency in muscle.
Wed Jan 01 00:00:00 UTC 2014
miR-181c regulates the mitochondrial genome, bioenergetics, and propensity for heart failure in vivo.
PloS one
Das S,Bedja D,Campbell N,Dunkerly B,Chenna V,Maitra A,Steenbergen C
A-6404 was used in western blot to study the effect of miR-181c administration in rats
Thu Jan 22 00:00:00 UTC 2015
The ratio of Mcl-1 and Noxa determines ABT737 resistance in squamous cell carcinoma of the skin.
Cell death & disease
Geserick P,Wang J,Feoktistova M,Leverkus M
A-6404 was used in western blot to analyze ABT737 resistance in squamous cell carcinoma of the skin determined by the ratio of Mcl-1 and Noxa
Thu Sep 11 00:00:00 UTC 2014
Mitochondria and tumor progression in ulcerative colitis.
Journal of the National Cancer Institute
Ussakli CH,Ebaee A,Binkley J,Brentnall TA,Emond MJ,Rabinovitch PS,Risques RA
Published figure using MTCO2 monoclonal antibody (Product # A-6404) in Immunohistochemistry
Wed Aug 21 00:00:00 UTC 2013
Ridaifen-SB8, a novel tamoxifen derivative, induces apoptosis via reactive oxygen species-dependent signaling pathway.
Biochemical pharmacology
Guo WZ,Shiina I,Wang Y,Umeda E,Watanabe C,Uetake S,Ohashi Y,Yamori T,Dan S
A-6404 was used in western blot to elucidate the mechanism by which RID-SB8 exerts anticancer activity.
Fri Nov 01 00:00:00 UTC 2013
Pilot application of iTRAQ to the retinal disease Macular Telangiectasia.
Journal of proteome research
Len AC,Powner MB,Zhu L,Hageman GS,Song X,Fruttiger M,Gillies MC
A-6404 was used in western blot to study the application of iTRAQ to the proteomic analysis of the retinal disease Macular Telangiectasia.
Fri Feb 03 00:00:00 UTC 2012
Identification of elongation factor G as the conserved cellular target of argyrin B.
PloS one
Nyfeler B,Hoepfner D,Palestrant D,Kirby CA,Whitehead L,Yu R,Deng G,Caughlan RE,Woods AL,Jones AK,Barnes SW,Walker JR,Gaulis S,Hauy E,Brachmann SM,Krastel P,Studer C,Riedl R,Estoppey D,Aust T,Movva NR,Wang Z,Salcius M,Michaud GA,McAllister G,Murphy LO,Tallarico JA,Wilson CJ,Dean CR
A-6404 was used in western blot to identify elongation factor G as the cellular target of argyrin B.
Wed May 01 00:00:00 UTC 2013
Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation.
Cell metabolism
Tucker EJ,Hershman SG,Köhrer C,Belcher-Timme CA,Patel J,Goldberger OA,Christodoulou J,Silberstein JM,McKenzie M,Ryan MT,Compton AG,Jaffe JD,Carr SA,Calvo SE,RajBhandary UL,Thorburn DR,Mootha VK
A-6404 was used in western blot to test the requirement of formylation for initiation in human mitochondria.
Wed Sep 07 00:00:00 UTC 2011
Cyclin D1 inhibits mitochondrial activity in B cells.
Cancer research
Tchakarska G,Roussel M,Troussard X,Sola B
A-6404 was used in immunocytochemistry to study the role of Cyclin D1 in mature B cells.
Tue Mar 01 00:00:00 UTC 2011
LMNA mutations induce a non-inflammatory fibrosis and a brown fat-like dystrophy of enlarged cervical adipose tissue.
The American journal of pathology
Béréziat V,Cervera P,Le Dour C,Verpont MC,Dumont S,Vantyghem MC,Capeau J,Vigouroux C
Published figure using MTCO2 monoclonal antibody (Product # A-6404) in Western Blot
Tue Nov 01 00:00:00 UTC 2011
Mitochondrial proteins, learning and memory: biochemical specialization of a memory system.
Neuroscience
Solomonia RO,Kunelauri N,Mikautadze E,Apkhazava D,McCabe BJ,Horn G
A-6404 was used in western blot to study cytochrome c oxidase subunits during learning.
Thu Oct 27 00:00:00 UTC 2011
Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit.
The Biochemical journal
Dennerlein S,Rozanska A,Wydro M,Chrzanowska-Lightowlers ZM,Lightowlers RN
A-6404 was used in western blot to investigate the localization and function of GTPase ERAL1
Wed Sep 15 00:00:00 UTC 2010
Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit.
The Biochemical journal
Dennerlein S,Rozanska A,Wydro M,Chrzanowska-Lightowlers ZM,Lightowlers RN
A-6404 was used in western blot to investigate the localization and function of GTPase ERAL1
Wed Sep 15 00:00:00 UTC 2010
PUMA- and Bax-induced autophagy contributes to apoptosis.
Cell death and differentiation
Yee KS,Wilkinson S,James J,Ryan KM,Vousden KH
Published figure using MTCO2 monoclonal antibody (Product # A-6404) in Western Blot
Sat Aug 01 00:00:00 UTC 2009
Altered gene transcription profiles in fibroblasts harboring either TK2 or DGUOK mutations indicate compensatory mechanisms.
Experimental cell research
Villarroya J,de Bolós C,Meseguer A,Hirano M,Vilà MR
A-6404 was used in western blot to compare the molecular genetic characteristics of fibroblasts derived from patients with different types of mitochondrial DNA depletion syndromes
Fri May 01 00:00:00 UTC 2009
A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas.
Leukemia
Balasubramanian S,Ramos J,Luo W,Sirisawad M,Verner E,Buggy JJ
A-6404 was used in western blot to examine the effects of HDAC8-selective inhibitors on T cell functions
Thu May 01 00:00:00 UTC 2008
Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats.
American journal of physiology. Heart and circulatory physiology
Ungvari Z,Labinskyy N,Gupte S,Chander PN,Edwards JG,Csiszar A
A-6404 was used in western blot to analyze mitochondrial biogenesis in smooth muscle and vascular endothelial cells dysregulation in aged rats
Thu May 01 00:00:00 UTC 2008
Perioculomotor cell groups in monkey and man defined by their histochemical and functional properties: reappraisal of the Edinger-Westphal nucleus.
The Journal of comparative neurology
Horn AK,Eberhorn A,Härtig W,Ardeleanu P,Messoudi A,Büttner-Ennever JA
A-6404 was used in immunohistochemistry to investigate the Edinger-Westphal nucleus in primates
Thu Mar 20 00:00:00 UTC 2008
Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence.
Cell death and differentiation
Caron M,Auclair M,Donadille B,Béréziat V,Guerci B,Laville M,Narbonne H,Bodemer C,Lascols O,Capeau J,Vigouroux C
A-6404 was used in Western Blotting to study how both LMNA mutations and protease inhibitor treatment result in accumulation of farnesylated prelamin A and oxidative stress, triggering cellular senescence.
Mon Oct 01 00:00:00 UTC 2007
Identification of mouse Prp19p as a lipid droplet-associated protein and its possible involvement in the biogenesis of lipid droplets.
The Journal of biological chemistry
Cho SY,Shin ES,Park PJ,Shin DW,Chang HK,Kim D,Lee HH,Lee JH,Kim SH,Song MJ,Chang IS,Lee OS,Lee TR
A-6404 was used in western blot to show Prp19p complexes with lipid droplet-associated proteins
Fri Jan 26 00:00:00 UTC 2007
Differential expression proteomics of human colon cancer.
American journal of physiology. Gastrointestinal and liver physiology
Mazzanti R,Solazzo M,Fantappié O,Elfering S,Pantaleo P,Bechi P,Cianchi F,Ettl A,Giulivi C
A-6404 was used in western blot study operative pathways in early stages of human colon cancer
Thu Jun 01 00:00:00 UTC 2006
Mcl-1 interacts with truncated Bid and inhibits its induction of cytochrome c release and its role in receptor-mediated apoptosis.
The Journal of biological chemistry
Clohessy JG,Zhuang J,de Boer J,Gil-Gómez G,Brady HJ
A-6404 was used in western blot to show a novel regulation of tBid by Mcl-1 through protein-protein interaction in apoptotic signaling from death receptors to mitochondria
Fri Mar 03 00:00:00 UTC 2006
Coordination of nuclear- and mitochondrial-DNA encoded proteins in cancer and normal colon tissues.
Biochimica et biophysica acta
Mazzanti R,Giulivi C
A-6404 was used in western blot to investigate how oxidative phosphorylation contributes to the coordination between nuclear- and mitochondria-encoded mitochondrial proteins
Fri Sep 29 00:00:00 UTC 2006
Heat shock pretreatment inhibited the release of Smac/DIABLO from mitochondria and apoptosis induced by hydrogen peroxide in cardiomyocytes and C2C12 myogenic cells.
Cell stress & chaperones
Jiang B,Xiao W,Shi Y,Liu M,Xiao X
Published figure using MTCO2 monoclonal antibody (Product # A-6404) in Western Blot
Thu Oct 20 00:00:00 UTC 2005
Tissue-specific cytochrome c oxidase assembly defects due to mutations in SCO2 and SURF1.
The Biochemical journal
Stiburek L,Vesela K,Hansikova H,Pecina P,Tesarova M,Cerna L,Houstek J,Zeman J
Thu Dec 15 00:00:00 UTC 2005
Localization of mitochondrial DNA encoded cytochrome c oxidase subunits I and II in rat pancreatic zymogen granules and pituitary growth hormone granules.
Histochemistry and cell biology
Sadacharan SK,Singh B,Bowes T,Gupta RS
A-6404 was used in immunohistochemistry to determine the subcellular localization of COX I and COX II in rat tissue sections
Tue Nov 01 00:00:00 UTC 2005
Cotreatment with histone deacetylase inhibitor LAQ824 enhances Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells.
Cancer research
Guo F,Sigua C,Tao J,Bali P,George P,Li Y,Wittmann S,Moscinski L,Atadja P,Bhalla K
A-6404 was used in western blot to analyze the enhancement of Apo-2L/tumor necrosis factor-related apoptosis inducing ligand-induced death inducing signaling complex activity and apoptosis of human acute leukemia cells by cotreatment with histone deacety
Thu Apr 01 00:00:00 UTC 2004
Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction.
Cellular and molecular life sciences : CMLS
Cheung NS,Choy MS,Halliwell B,Teo TS,Bay BH,Lee AY,Qi RZ,Koh VH,Whiteman M,Koay ES,Chiu LL,Zhu HJ,Wong KP,Beart PM,Cheng HC
A-6404 was used in western blot to examine the recruitment of PTEN to the plasma membrane
Sun Aug 01 00:00:00 UTC 2004
Oxidative stress and the mitochondrial theory of aging in human skeletal muscle.
Experimental gerontology
Gianni P,Jan KJ,Douglas MJ,Stuart PM,Tarnopolsky MA
A-6404 was used in western blot to report age-related mitochondrial changes in healthy adults
Wed Sep 01 00:00:00 UTC 2004
Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death.
The Journal of biological chemistry
Guo Y,Cheong N,Zhang Z,De Rose R,Deng Y,Farber SA,Fernandes-Alnemri T,Alnemri ES
A-6404 was used in Western Blotting to identify and characterise a novel human mitochondrial inner membrane protein homologous to yeast Tim50.
Fri Jun 04 00:00:00 UTC 2004
Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death.
The Journal of biological chemistry
Guo Y,Cheong N,Zhang Z,De Rose R,Deng Y,Farber SA,Fernandes-Alnemri T,Alnemri ES
A-6404 was used in Western Blotting to identify and characterise a novel human mitochondrial inner membrane protein homologous to yeast Tim50.
Fri Jun 04 00:00:00 UTC 2004
Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells.
American journal of physiology. Endocrinology and metabolism
Chen JQ,Delannoy M,Cooke C,Yager JD
A-6404 was used in Western Blot to characterise the mitochondrial localisation of oestrogen receptors alpha and beta in human MCF7 cells.
Tue Jun 01 00:00:00 UTC 2004
Mitochondrially localized active caspase-9 and caspase-3 result mostly from translocation from the cytosol and partly from caspase-mediated activation in the organelle. Lack of evidence for Apaf-1-mediated procaspase-9 activation in the mitochondria.
The Journal of biological chemistry
Chandra D,Tang DG
A-6404 was used in Western Blotting to show that the mitochondrial active caspases may function as a positive feedback mechanism to further activate residual mitochondrial procaspases, degrade mitochondrial constituents, and disintegrate mitochondrial functions.
Fri May 09 00:00:00 UTC 2003
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.
The Journal of biological chemistry
Guo Y,Srinivasula SM,Druilhe A,Fernandes-Alnemri T,Alnemri ES
A-6404 was used in Western Blotting to suggest that caspase-2 is a direct effector of the mitochondrial apoptotic pathway.
Fri Apr 19 00:00:00 UTC 2002
Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria.
The Journal of biological chemistry
Guo Y,Srinivasula SM,Druilhe A,Fernandes-Alnemri T,Alnemri ES
A-6404 was used in Western Blotting to suggest that caspase-2 is a direct effector of the mitochondrial apoptotic pathway.
Fri Apr 19 00:00:00 UTC 2002
Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis.
The Journal of biological chemistry
Gajate C,An F,Mollinedo F
A-6404 was used in western blot to investigate the cellular effects of ecteinascidin-743 treatment
Fri Nov 01 00:00:00 UTC 2002
Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription.
The Journal of biological chemistry
Rokhlin OW,Glover RA,Taghiyev AF,Guseva NV,Seftor RE,Shyshynova I,Gudkov AV,Cohen MB
A-6404 was used in western blot to analyze facilitation of tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription by bisindolylmaleimide IX
Fri Sep 06 00:00:00 UTC 2002
Early mitochondrial activation and cytochrome c up-regulation during apoptosis.
The Journal of biological chemistry
Chandra D,Liu JW,Tang DG
A-6404 was used in Western Blotting to show that apoptosis induced by multiple stimuli is preceded by an early induction of mitochondrial respiratory chain proteins.
Fri Dec 27 00:00:00 UTC 2002
Bid, a widely expressed proapoptotic protein of the Bcl-2 family, displays lipid transfer activity.
Molecular and cellular biology
Esposti MD,Erler JT,Hickman JA,Dive C
A-6404 was used to elucidate a widely expressed proapoptotic protein of the Bcl-2 family, called Bid, that displays lipid transfer activity
Thu Nov 01 00:00:00 UTC 2001
Role of mitochondria and caspases in vitamin D-mediated apoptosis of MCF-7 breast cancer cells.
The Journal of biological chemistry
Narvaez CJ,Welsh J
A-6404 was used in western blot to investigate the role of caspase activation and mitochondrial disruption in 1alpha,25(OH)(2)D(3)-mediated apoptosis in breast cancer cells
Fri Mar 23 00:00:00 UTC 2001
Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: evidence for a mitochondrial pathway independent of the permeability transition.
Journal of neurochemistry
Rodrigues CM,Stieers CL,Keene CD,Ma X,Kren BT,Low WC,Steer CJ
A-6404 was used in western blot to elucidate the mechanism by which tauroursodeoxycholic acid inhibits 3-nitropropionic acid-induced apoptosis
Fri Dec 01 00:00:00 UTC 2000
The chaperone function of hsp70 is required for protection against stress-induced apoptosis.
Molecular and cellular biology
Mosser DD,Caron AW,Bourget L,Meriin AB,Sherman MY,Morimoto RI,Massie B
Published figure using MTCO2 monoclonal antibody (Product # A-6404) in Western Blot
Sun Oct 01 00:00:00 UTC 2000
TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions.
Proceedings of the National Academy of Sciences of the United States of America
Syken J,De-Medina T,Münger K
Published figure using MTCO2 monoclonal antibody (Product # A-6404) in Western Blot
Tue Jul 20 00:00:00 UTC 1999
Dual targeting property of the N-terminal signal sequence of P4501A1. Targeting of heterologous proteins to endoplasmic reticulum and mitochondria.
The Journal of biological chemistry
Bhagwat SV,Biswas G,Anandatheerthavarada HK,Addya S,Pandak W,Avadhani NG
A-6404 was used in immunocytochemistry to assess the ability of the N-terminal signal sequence of P4501A1 to target heterologous proteins to the endoplasmic reticulum and mitochondria
Fri Aug 20 00:00:00 UTC 1999
Mammalian cytochrome-c oxidase: characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells.
Methods in enzymology
Capaldi RA,Marusich MF,Taanman JW
A-6404 was used in western blot to Mammalian cytochrome-c oxidase: characterization of enzyme and immunological detection of subunits in tissue extracts and whole cells
Mon Apr 01 00:00:00 UTC 1996
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.jpg?time=20250104?time=20250104 "MTCO2 Antibody (A-6404) in WB")
.jpg?time=20250104?time=20250104 "MTCO2 Antibody (A-6404) in WB")
.jpg?time=20250104?time=20250104 "MTCO2 Antibody (A-6404) in WB")
