Proteintech

MTF1 Polyclonal Antibody

MTF1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MTF1 Antibody (25383-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver tissue slide using 25383-1-AP ( MTF1 Antibody) at dilution of 1:200 (under 40x lens).

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Product Details

25383-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

ChIP assay (ChIP)

View 3 publications 3 publications

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Fish, Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MTF1 Fusion Protein Ag21848 (404-753 aa encoded by BC014454)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.24 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: VSDVPPSTG NSASLSLPLV LQPGLSEPPQ PLLPASAPSA PPPAPSLGPG SQQAAFGNPP ALLQPPEVPV PHSTQFAANH QEFLPHPQAP QPIVPGLSVV AGASASAAAV ASAVAAPAPP QSTTEPLPAM VQTLPLGANS VLTNNPTITI TPTPNTAILQ SSLVMGEQNL QWILNGATSS PQNQEQIQQA SKVEKVFFTT AVPVASSPGS SVQQIGLSVP VIIIKQEEAC QCQCACRDSA KERASSRRKG CSSPPPPEPS PQAPDGPSLQ LPAQTFSSAP VPGSSSSTLP SSCEQSRQAE TPSDPQTETL SAMDVSEFLS LQSLDTPSNL IPIEALLQGE EEMGLTSSFS K (404-753 aa encoded by BC014454)

Target Information

This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

lncRNA SND1-IT1 delivered via intracerebral hemorrhage-derived exosomes affect the growth of human microglia by regulating the miR-124-3p/MTF1 axis.

Journal of cellular physiology

Wang J,Teng F,Liu S,Pan X,Yang B,Wu W

Wed Feb 01 00:00:00 UTC 2023

Regulatory effects mediated by ulvan oligosaccharide and its zinc complex on lipid metabolism in high-fat diet-fed mice.

Carbohydrate polymers

Chi Y,Wu Z,Du C,Zhang M,Wang X,Xie A,Wang P,Li R

Sun Jan 15 00:00:00 UTC 2023

Bioinformatics-Based Analysis of Key Genes in Steroid-Induced Osteonecrosis of the Femoral Head That Are Associated with Copper Metabolism.

Biomedicines

Qi B,Li C,Cai X,Pu L,Guo M,Tang Z,Bu P,Xu Y

Mon Mar 13 00:00:00 UTC 2023

The biological significance of cuproptosis-key gene MTF1 in pan-cancer and its inhibitory effects on ROS-mediated cell death of liver hepatocellular carcinoma.

Discover oncology

Song L,Zeng R,Yang K,Liu W,Xu Z,Kang F

Wed Jun 28 00:00:00 UTC 2023

Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.

Chemistry & biodiversity

Yang Y,Qian Cai Q,Sheng Fu L,Wei Dong Y,Fan F,Zhong Wu X

Tue Nov 01 00:00:00 UTC 2022

Reduced N6-Methyladenosine Mediated by METTL3 Acetylation Promotes MTF1 Expression and Hepatocellular Carcinoma Cell Growth.

Chemistry & biodiversity

Yang Y,Qian Cai Q,Sheng Fu L,Wei Dong Y,Fan F,Zhong Wu X

Tue Nov 01 00:00:00 UTC 2022

Manganese-Induced Oxidative Stress Contributes to Intestinal Lipid Deposition via the Deacetylation of PPARγ at K339 by SIRT1.

Antioxidants & redox signaling

Lv WH,Zhao T,Pantopoulos K,Chen GH,Wei XL,Zhang DG,Luo Z

Thu Sep 01 00:00:00 UTC 2022

Loss of MBD2 ameliorates LPS-induced alveolar epithelial cell apoptosis and ALI in mice via modulating intracellular zinc homeostasis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Liu J,Yao S,Jia J,Chen Z,Yuan Y,He Y,Wasti B,Duan W,Li D,Wang G,Jia A,Sun W,Qiu S,Ma L,Li J,Liu Y,Zheng J,Xiang X,Zhang X,Liu S,He Z,Peng Z,Zhang H,Zhang D,Xiao B

Tue Feb 01 00:00:00 UTC 2022

Loss of MBD2 ameliorates LPS-induced alveolar epithelial cell apoptosis and ALI in mice via modulating intracellular zinc homeostasis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Liu J,Yao S,Jia J,Chen Z,Yuan Y,He Y,Wasti B,Duan W,Li D,Wang G,Jia A,Sun W,Qiu S,Ma L,Li J,Liu Y,Zheng J,Xiang X,Zhang X,Liu S,He Z,Peng Z,Zhang H,Zhang D,Xiao B

Tue Feb 01 00:00:00 UTC 2022

Mitochondria-Dependent Oxidative Stress Mediates ZnO Nanoparticle (ZnO NP)-Induced Mitophagy and Lipotoxicity in Freshwater Teleost Fish.

Environmental science & technology

Chen GH,Song CC,Zhao T,Hogstrand C,Wei XL,Lv WH,Song YF,Luo Z

Tue Feb 15 00:00:00 UTC 2022

A circuit of COCH neurons encodes social-stress-induced anxiety via MTF1 activation of Cacna1h.

Cell reports

Jing W,Zhang T,Liu J,Huang X,Yu Q,Yu H,Zhang Q,Li H,Deng M,Zhu LQ,Du H,Lu Y

Tue Dec 28 00:00:00 UTC 2021

Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.

Oxidative medicine and cellular longevity

Lu S,Song Y,Luo R,Li S,Li G,Wang K,Liao Z,Wang B,Ke W,Xiang Q,Chen C,Wu X,Zhang Y,Ling L,Yang C

Thu Sep 09 00:00:00 UTC 2021

Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo.

Oxidative medicine and cellular longevity

Lu S,Song Y,Luo R,Li S,Li G,Wang K,Liao Z,Wang B,Ke W,Xiang Q,Chen C,Wu X,Zhang Y,Ling L,Yang C

Thu Sep 09 00:00:00 UTC 2021

Autophagy of the m⁶A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis.

Nature communications

Cui YH,Yang S,Wei J,Shea CR,Zhong W,Wang F,Shah P,Kibriya MG,Cui X,Ahsan H,He C,He YY

Mon Apr 12 00:00:00 UTC 2021

Zn Induces Lipophagy via the Deacetylation of Beclin1 and Alleviates Cu-Induced Lipotoxicity at Their Environmentally Relevant Concentrations.

Environmental science & technology

Wei X,Hogstrand C,Chen G,Lv W,Song Y,Xu Y,Luo Z

Tue Apr 20 00:00:00 UTC 2021

Zn Induces Lipophagy via the Deacetylation of Beclin1 and Alleviates Cu-Induced Lipotoxicity at Their Environmentally Relevant Concentrations.

Environmental science & technology

Wei X,Hogstrand C,Chen G,Lv W,Song Y,Xu Y,Luo Z

Tue Apr 20 00:00:00 UTC 2021

Transcriptional responses of four slc30a/znt family members and their roles in Zn homeostatic modulation in yellow catfish Pelteobagrus fulvidraco.

Biochimica et biophysica acta. Gene regulatory mechanisms

Song CC,Chen GH,Zhong CC,Chen F,Chen SW,Luo Z

Sun Aug 01 00:00:00 UTC 2021

Dietary Nano-ZnO Is Absorbed via Endocytosis and ZIP Pathways, Upregulates Lipogenesis, and Induces Lipotoxicity in the Intestine of Yellow Catfish.

International journal of molecular sciences

Chen SW,Lv WH,Wu K,Chen GH,Chen F,Song CC,Luo Z

Sun Nov 07 00:00:00 UTC 2021

Nano-Zn Increased Zn Accumulation and Triglyceride Content by Up-Regulating Lipogenesis in Freshwater Teleost, Yellow Catfish Pelteobagrus fulvidraco.

International journal of molecular sciences

Ling SC,Zhuo MQ,Zhang DG,Cui HY,Luo Z

Thu Feb 27 00:00:00 UTC 2020

lncRNA LINC00665 Stabilized by TAF15 Impeded the Malignant Biological Behaviors of Glioma Cells via STAU1-Mediated mRNA Degradation.

Molecular therapy. Nucleic acids

Ruan X,Zheng J,Liu X,Liu Y,Liu L,Ma J,He Q,Yang C,Wang D,Cai H,Li Z,Liu J,Xue Y

Fri Jun 05 00:00:00 UTC 2020

Salmonella effector SpvB interferes with intracellular iron homeostasis via regulation of transcription factor NRF2.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Yang S,Deng Q,Sun L,Dong K,Li Y,Wu S,Huang R

Sun Dec 01 00:00:00 UTC 2019

Zinc reduces hepatic lipid deposition and activates lipophagy via Zn²⁺/MTF-1/PPARα and Ca²⁺/CaMKKβ/AMPK pathways.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Wei CC,Luo Z,Hogstrand C,Xu YH,Wu LX,Chen GH,Pan YX,Song YF

Mon Jun 18 00:00:00 UTC 2018

Zinc reduces hepatic lipid deposition and activates lipophagy via Zn²⁺/MTF-1/PPARα and Ca²⁺/CaMKKβ/AMPK pathways.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Wei CC,Luo Z,Hogstrand C,Xu YH,Wu LX,Chen GH,Pan YX,Song YF

Mon Jun 18 00:00:00 UTC 2018

An MTF1 binding site disrupted by a homozygous variant in the promoter of ATP7B likely causes Wilson Disease.

European journal of human genetics : EJHG

Chen HI,Jagadeesh KA,Birgmeier J,Wenger AM,Guturu H,Schelley S,Bernstein JA,Bejerano G

Sat Dec 01 00:00:00 UTC 2018

An MTF1 binding site disrupted by a homozygous variant in the promoter of ATP7B likely causes Wilson Disease.

European journal of human genetics : EJHG

Chen HI,Jagadeesh KA,Birgmeier J,Wenger AM,Guturu H,Schelley S,Bernstein JA,Bejerano G

Sat Dec 01 00:00:00 UTC 2018

LncRNA MT1DP Aggravates Cadmium-Induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with miR-365.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Gao M,Li C,Xu M,Liu Y,Cong M,Liu S

Sun Jul 01 00:00:00 UTC 2018

LncRNA MT1DP Aggravates Cadmium-Induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with miR-365.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Gao M,Li C,Xu M,Liu Y,Cong M,Liu S

Sun Jul 01 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: Metal regulatory transcription factor 1; metal-regulatory transcription factor 1; metal-responsive transcription factor 1; metalloregulatory transcription factor; MRE-binding transcription factor; MRE-binding transcription factor-1; Transcription factor MTF-1; zinc regulatory factor

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Gene Aliases: MTF-1; MTF1; Thyls; ZRF

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UniProt ID: (Human) Q14872, (Mouse) Q07243

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Entrez Gene ID: (Human) 4520, (Mouse) 17764

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription coactivator activity protein binding histone acetyltransferase binding metal ion binding nucleic acid binding

Process(es)

regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter response to oxidative stress response to metal ion positive regulation of transcription from RNA polymerase II promoter response to cadmium ion transcription, DNA-templated regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated transition metal ion homeostasis

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MTF1 Polyclonal Antibody

MTF1 Antibody (25383-1-AP) in IHC (P)

Product Details

25383-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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