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Invitrogen
MTG16 Polyclonal Antibody
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FIGURE: 1 / 1
MTG16 Antibody (PA5-89998) in WB
Western blot analysis of MTG16 in various lysates. Samples were incubated with MTG16 Polyclonal antibody (Product # PA5-89998) using a dilution of 1:400, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
PA5-89998
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 593-653 of human CBFA2T3 (NP_0051784)
Conjugate
Form
Liquid
Concentration
0.85 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2805885
Product Specific Information
Positive Samples: K-562, U-251MG; Cellular Location: Golgi apparatus membrane, Nucleus, nucleolus, nucleoplasm
Immunogen sequence: GQSLQGPTAV VADPVPGPPE AAHSLGPSLP VGAASPSEAG SAGPSRPGSP SPPGPLDTVP R
Target Information
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: core-binding factor, runt domain, alpha subunit 2; translocated to, 3; Eight twenty one protein 2; ETO/MTG8-related protein ETO-2; hMTG16; MTG16HEL; MTG8-related gene 2; MTG8-related protein 2; myeloid translocation gene 8 and 16b; Myeloid translocation gene on chromosome 16 protein; myeloid translocation gene-related protein 2; Protein CBFA2T3; Protein ETO-2; translocated to, 3; Zinc finger MYND domain-containing protein 4
Gene Aliases: A630044F12Rik; AI465270; AW229127; CBFA2T3; Cbfa2t3h; ETO-2; ETO2; MTG16; MTGR2; RUNX1T3; ZMYND4
UniProt ID: (Human) O75081, (Mouse) O54972
Entrez Gene ID: (Human) 863, (Mouse) 12398, (Rat) 361431
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
cell differentiation
granulocyte differentiation
negative regulation of nucleic acid-templated transcription
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to hypoxia
cell proliferation
negative regulation of cell proliferation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of glycolytic process
regulation of aerobic respiration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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