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Product Details
PA5-76315
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein of human MTHFD1L.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2720042
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
One-carbon substituted forms of tetrahydrofolate (THF) are involved in the de novo synthesis of purines and thymidylate and support cellular methylation reactions through the regeneration of methionine from homocysteine. MTHFD1L is an enzyme involved in THF synthesis in mitochondria (Christensen et al., 2005 [PubMed 15611115]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 10-formyl-THF synthetase; Formyltetrahydrofolate synthetase; formyltetrahydrofolate synthetase domain containing 1; Monofunctional C1-tetrahydrofolate synthase, mitochondrial
Gene Aliases: 2410004L15Rik; AI647056; dJ292B18.2; FTHFSDC1; MTC1THFS; MTHFD1L
UniProt ID: (Human) Q6UB35, (Mouse) Q3V3R1
Entrez Gene ID: (Human) 25902, (Rat) 361472, (Mouse) 270685
one-carbon metabolic process
folic acid-containing compound metabolic process
biological_process
folic acid-containing compound biosynthetic process
formate metabolic process
tetrahydrofolate metabolic process
oxidation-reduction process
10-formyltetrahydrofolate biosynthetic process
neural tube closure
tetrahydrofolate interconversion
folic acid metabolic process
embryonic neurocranium morphogenesis
embryonic viscerocranium morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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