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Invitrogen
MTM1 Polyclonal Antibody
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MTM1 Antibody (PA5-116357) in WB
Western Blot analysis of MTM1 using the MTM1 Polyclonal Antibody (Product # PA5-116357) at a 1:2000 dilution. ZF4 whole cell lysates were loaded at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10,000 dilution Predicted band size: 74 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Product Details
PA5-116357
Product Specifications
Species Reactivity
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 451-485 amino acids from the region of DANRE mtm1
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2900991
Target Information
Human MTM1, a 603 amino-acid protein, is mutated in myotubular myopathy. The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-tooth neuropathy. Myotubularin is primarily a lipid phosphatase that acts on hosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI 3-kinase) pathway and membrane trafficking. Wildtype myotubularin can directly dephosphorylate PI 3-P and PI 4-P in vitro. Thus, it decreases PI 3-P levels by down-regulating PI 3-K activity and by facilitating the degradation of PI 3-P.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Gene Aliases: fb19c01; im:6903724; wu:fb19c01; zgc:123266
Entrez Gene ID: (Zebrafish) 560881
skeletal muscle tissue development
somatic muscle development
neuromuscular junction development
locomotory behavior
endosome to lysosome transport
regulation of autophagy
dephosphorylation
chordate embryonic development
regulation of vacuole organization
intermediate filament organization
muscle cell cellular homeostasis
phosphatidylinositol dephosphorylation
mitochondrion distribution
skeletal muscle fiber development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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