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MTMR3 Antibody (PA5-109990) in WB
Western blot analysis of MTMR3 in extracts of various cell lines. Samples were incubated with MTMR3 Polyclonal antibody (Product # PA5-109990) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-109990
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 640-810 of human MTMR3 (NP_066576.1).
Conjugate
Form
Liquid
Concentration
1.64 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2855401
Product Specific Information
Immunogen sequence: KWQEHRRSLE LSSLAGPGED PLSADSLGKP TRVPGGAELS VAAGVAEGQM ENILQEATKE ESGVEEPAHR AGIEIQEGKE DPLLEKESRR KTPEASAIGL HQDPELGDAA LRSHLDMSWP LFSQGISEQQ SGLSVLLSSL QVPPRGEDSL EVPVEQFRIE EIAEGREEAV L
Target Information
This gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition contains a FYVE domain and an N-terminal PH-GRAM domain. The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol(3)-phosphate and phosphatidylinositol(3,5)-bisphosphate in vitro. The encoded protein has been observed to have a perinuclear, possibly membrane-bound, distribution in cells, but it has also been found free in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphatase; FYVE domain-containing dual specificity protein phosphatase 1; FYVE-DSP1; Myotubularin-related protein 3; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3; Phosphatidylinositol-3-phosphate phosphatase; Zinc finger FYVE domain-containing protein 10; zinc finger, FYVE domain containing 10
Gene Aliases: FYVE-DSP1; KIAA0371; MTMR3; ZFYVE10
UniProt ID: (Human) Q13615
Entrez Gene ID: (Human) 8897
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