Invitrogen

MTMR6 Polyclonal Antibody

View all (6) MTMR6 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-90399

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 382-621 of human MTMR6 (NP_0046763)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.03 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2806051

Product Specific Information

Immunogen sequence: RCGQLDGDPK EVSPVFTQFL ECVWHLTEQF PQAFEFSEAF LLQIHEHIHS CQFGNFLGNC QKEREELKLK EKTYSLWPFL LEDQKKYLNP LYSSESHRFT VLEPNTVSFN FKFWRNMYHQ FDRTLHPRQS VFNIIMNMNE QNKQLEKDIK DLESKIKQRK NKQTDGILTK ELLHSVHPES PNLKTSLCFK EQTLLPVNDA LRTIEGSSPA DNRYSEYAEE FSKSEPAVVS LEYGVARMTC; Positive Samples: HepG2, HeLa, 293T, Mouse heart, Mouse brain, Mouse lung, Mouse spleen, Mouse testis, Rat heart; Cellular Location: Nucleus envelope

Target Information

Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:19038970, PubMed:22647598). Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate (PubMed:19038970, PubMed:22647598) (Probable). Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (PubMed:19038970). Negatively regulates ER-Golgi protein transport. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate (PubMed:15831468). Negatively regulates proliferation of reactivated CD4(+) T-cells (PubMed:16847315). In complex with MTMR9, negatively regulates DNA damage-induced apoptosis (PubMed:19038970, PubMed:22647598). The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (PubMed:19038970). [UniProt]

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: mtmr6; Myotubularin-related protein 6; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6; Phosphatidylinositol-3-phosphate phosphatase

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Gene Aliases: 4022440C11Rik; AI428804; AU041072; MTMR6

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UniProt ID: (Human) Q9Y217, (Mouse) Q8VE11

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Entrez Gene ID: (Human) 9107, (Rat) 305935, (Mouse) 219135

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Function(s)
phosphatidylinositol-3-phosphatase activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein binding calcium-activated potassium channel activity phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity phosphatase activity protein tyrosine/serine/threonine phosphatase activity protein tyrosine/threonine phosphatase activity JUN kinase phosphatase activity phosphohistidine phosphatase activity inositol bisphosphate phosphatase activity hydrolase activity MAP kinase tyrosine/serine/threonine phosphatase activity inositol-1,3,4-trisphosphate 4-phosphatase activity NADP phosphatase activity transmembrane receptor protein phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity inositol-4,5-bisphosphate 5-phosphatase activity 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity phosphatidylinositol-4-phosphate phosphatase activity phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity inositol phosphate phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity inositol-3,4-bisphosphate 4-phosphatase activity inositol-1,3,4-trisphosphate 1-phosphatase activity inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity IDP phosphatase activity
Process(es)
dephosphorylation potassium ion transmembrane transport protein dephosphorylation phosphatidylinositol biosynthetic process peptidyl-tyrosine dephosphorylation phosphatidylinositol dephosphorylation
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