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Invitrogen
MTSS1 Polyclonal Antibody
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MTSS1 Antibody (PA5-116535) in WB
Western blot analysis of MTSS1 in extracts of various cell lines. Samples were incubated with MTSS1 Polyclonal antibody (Product # PA5-116535) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
PA5-116535
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 630-730 of human MTSS1 (NP_0555663)
Conjugate
Form
Liquid
Concentration
0.88 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901166
Product Specific Information
Positive Samples: HeLa, HT-29, U-87MG, Mouse liver, Mouse brain, Mouse heart, Rat liver
Immunogen sequence: LPAPPDGPEE RGEHSPESPS VGEGPQGVTS MPSSMWSGQA SVNPPLPGPK PSIPEEHRQA IPESEAEDQE REPPSATVSP GQIPESDPAD LSPRDTPQGE D
Target Information
Metastasis suppressor protein 1 (MTSS1) [MIM, "missing in metastasis"], was first discovered as missing transcripts from metastatic bladder and prostate cancer cells. MTSS1 is a 755 amino acid protein, having multidomain and scaffolding function. It has a proline-rich/SH3 binding region and a serine-rich region with EGF or PDGF/Src consensus sites. It contains anactin-binding Wiskott-Aldrich syndrome protein homology-2 motif (WH2) at the C-terminus while the N-terminal IMD domain (IRSp53-MIM domain) interact with membranes and bundle actin filament. The WH2 domain binds to actin monomers and plays an important role in actin cytoskeleton reorganization. Recently, MIM was found to interact with cortactin via SH3 domains. In addition, MTSS1 enhanced cortactin- and Arp2/3-dependent actin polymerization. It is thus involved in cell motility and morphogenesis and also interacts with sonic hedgehog/Gli signaling in epidermal cells. MTSS1 acts as an important regulator of cell growth and development and is known to express in many tissues, including spleen, thymus, prostate, testis, uterus, colon, and peripheral blood.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: actin monomer-binding protein; Metastasis suppressor protein 1; Metastasis suppressor YGL-1; Missing in metastasis protein; Protein MTSS 1
Gene Aliases: 2310003N14Rik; BC024131; D130001D01Rik; KIAA0429; MIM; MIMA; MIMB; mKIAA0429; MTSS1
UniProt ID: (Human) O43312, (Mouse) Q8R1S4
Entrez Gene ID: (Human) 9788, (Rat) 362918, (Mouse) 211401
in utero embryonic development
plasma membrane organization
actin filament organization
magnesium ion homeostasis
actin filament polymerization
bone mineralization
positive regulation of actin filament bundle assembly
adherens junction maintenance
negative regulation of epithelial cell proliferation
renal tubule morphogenesis
cellular response to fluid shear stress
renal system development
glomerulus morphogenesis
nephron tubule epithelial cell differentiation
epithelial cell proliferation involved in renal tubule morphogenesis
positive regulation of defense response to virus by host
movement of cell or subcellular component
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
microspike assembly
actin cytoskeleton organization
xenophagy
nervous system development
muscle organ development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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