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Invitrogen
MUL1 Polyclonal Antibody
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Product Details
PA5-113767
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human C1orf166
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2884282
Product Specific Information
Immunogen sequence: GMQYYLSSQD FDSLLQRQES SVRLWKVLAL VFGFATCATL FFILRKQYLQ
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%
Target Information
E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 SUMO-protein ligase MUL1; E3 ubiquitin ligase; E3 ubiquitin-protein ligase MUL1; Growth inhibition and death E3 ligase; mitochondria-anchored protein ligase; mitochondrial E3 ubiquitin ligase 1; mitochondrial ubiquitin ligase activator of NF-kB; Mitochondrial ubiquitin ligase activator of NFKB 1; Mitochondrial-anchored protein ligase; Protein Hades; Putative NF-kappa-B-activating protein 266; RING finger protein 218; RING-type E3 ubiquitin transferase NFKB 1; RP11-401M16.2
Gene Aliases: C1orf166; GIDE; MAPL; MUL1; MULAN; RNF218
UniProt ID: (Human) Q969V5
Entrez Gene ID: (Human) 79594
mitochondrial fission
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
activation of JUN kinase activity
negative regulation of mitochondrial fusion
regulation of mitochondrion organization
protein ubiquitination
protein sumoylation
negative regulation of cell growth
protein destabilization
positive regulation of protein sumoylation
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of innate immune response
negative regulation of defense response to virus by host
protein stabilization
mitochondrion localization
regulation of mitochondrial membrane potential
negative regulation of protein kinase B signaling
negative regulation of type I interferon-mediated signaling pathway
cellular response to exogenous dsRNA
negative regulation of chemokine (C-C motif) ligand 5 production
positive regulation of mitochondrial fission
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of dendrite extension
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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