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Invitrogen
MUNC18 Polyclonal Antibody
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MUNC18 Antibody (PA5-148231) in IP
Immunoprecipitation of MUNC18 in various lysates. Samples were incubated with MUNC18 polyclonal antibody (Product # PA5-148231) using a dilution of 1:100 followed by Goat Anti-Rabbit IgG (H+L)/HRP secondary antibody at a dilution of 1:10,000. Lane A: 0.5 mg Jurkat Whole Cell Lysate; Lane B: 0.5 mg shsy5y Whole Cell Lysate. 4 µL anti-HG3C-STXBP1 rabbit polyclonal antibody and 60 μg of Immunomagnetic beads Protein A/G. Developed using the ECL technique. Performed under reducing conditions. Predicted band size: 68 kDa; Observed band size: 68 ... View More
Product Details
PA5-148231
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Munc18-1/STXBP1 Protein (Met1-Ser594)
Conjugate
Form
Liquid
Concentration
100 mg/mL
Purification
Antigen affinity chromatography, Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3247400
Target Information
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EIEE4; FLJ37475; hUNC18; MGC146482; munc-18c; MUNC18-1; N-Sec1; neuronal SEC1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; rop; RP11-56D16.3; Syntaxin-binding protein 1; Unc-18A; Unc18-1
Gene Aliases: MUNC18-1; NSEC1; P67; RBSEC1; STXBP1; UNC18; UNC18A
UniProt ID: (Human) P61764
Entrez Gene ID: (Human) 6812
platelet degranulation
vesicle docking involved in exocytosis
neurotransmitter secretion
neuromuscular synaptic transmission
axon target recognition
regulation of synaptic vesicle priming
glutamate secretion
protein transport
synaptic vesicle maturation
regulation of synaptic vesicle fusion to presynaptic membrane
negative regulation of synaptic transmission, GABAergic
regulation of SNARE complex assembly
negative regulation of neuron apoptotic process
positive regulation of calcium ion-dependent exocytosis
protein stabilization
long term synaptic depression
platelet aggregation
protein localization to plasma membrane
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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