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Invitrogen
MUNC18 Polyclonal Antibody
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MUNC18 Antibody (PA5-18212) in IHC (P)
Immunohistochemistry analysis of MUNC18 in human brain, cortex. Samples were incubated with MUNC18 polyclonal antibody (Product # PA5-18212) using a dilution of 5 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-18212
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (SRVSFEDQAPTME) corresponding to the C-terminus amino acids of STXBP1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10979941
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EIEE4; FLJ37475; hUNC18; MGC146482; munc-18c; MUNC18-1; N-Sec1; neuronal SEC1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; rop; RP11-56D16.3; Syntaxin-binding protein 1; Unc-18A; Unc18-1
Gene Aliases: MUNC18-1; NSEC1; P67; RBSEC1; STXBP1; UNC18; UNC18A
UniProt ID: (Human) P61764
Entrez Gene ID: (Human) 6812
platelet degranulation
vesicle docking involved in exocytosis
neurotransmitter secretion
neuromuscular synaptic transmission
axon target recognition
regulation of synaptic vesicle priming
glutamate secretion
protein transport
synaptic vesicle maturation
regulation of synaptic vesicle fusion to presynaptic membrane
negative regulation of synaptic transmission, GABAergic
regulation of SNARE complex assembly
negative regulation of neuron apoptotic process
positive regulation of calcium ion-dependent exocytosis
protein stabilization
long term synaptic depression
platelet aggregation
protein localization to plasma membrane
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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