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Invitrogen
MUNC18 Recombinant Rabbit Monoclonal Antibody (1N7U1)
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FIGURE: 1 / 7
MUNC18 Antibody (MA5-35796) in ICC/IF
Immunofluorescence of MUNC18 was performed using U-87 MG WT and MUNC18 KO cells that were labeled with a green or a far-red fluorescent dye, respectively. Post-labeling, WT and KO cells were mixed and plated to a 1:1 ratio in a 96-well plate with an optically clear flat bottom as a mosaic and incubated for 24 hrs. Cells were fixed in 4% PFA (in PBS) for 15 min at RT; cells were permeabilized with 0.1% Triton X-100 for 10 min at RT and blocked with PBS containing 5% BSA, 5% goat serum, and 0.01% Triton X-100 for 30 min at RT. Cells were sta... View More
Product Details
MA5-35796
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
1N7U1
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human STXBP1 (P61764)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849696
Product Specific Information
Immunogen sequence: STYDKIRIIL LYIFLKNGIT EENLNKLIQH AQIPPEDSEI ITNMAHLGVP IVTDSTLRRR SKPERKERIS EQTYQLSRWT PIIKDIMEDT IEDKLDTKHY P
Target Information
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EIEE4; FLJ37475; hUNC18; MGC146482; minisatellite 10g detected by probe MMS10; munc-18c; MUNC18-1; N-Sec1; neuronal SEC1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; rbSec1; rop; RP11-56D16.3; Syntaxin-binding protein 1; UNC-18 homolog; unc-18-1; Unc-18A; Unc18-1
Gene Aliases: AI317162; AI326233; ANC18HA; MMS10-G; Ms10g; Munc-18a; MUNC18-1; N-sec1; NSEC1; NSEC1A; P67; Rb-sec1; RBSEC1; rbSec1A; rbSec1B; Sec1; STXBP1; Sxtbp1; UNC18; Unc18-1; UNC18A; Unc18h
UniProt ID: (Human) P61764, (Mouse) O08599, (Rat) P61765
Entrez Gene ID: (Human) 6812, (Mouse) 20910, (Rat) 25558
platelet degranulation
transport
exocytosis
vesicle docking involved in exocytosis
neurotransmitter secretion
neuromuscular synaptic transmission
axon target recognition
regulation of synaptic vesicle priming
protein transport
synaptic vesicle maturation
vesicle-mediated transport
synaptic vesicle fusion to presynaptic active zone membrane
negative regulation of synaptic transmission, GABAergic
negative regulation of neuron apoptotic process
positive regulation of exocytosis
positive regulation of calcium ion-dependent exocytosis
protein stabilization
long term synaptic depression
platelet aggregation
protein localization to plasma membrane
glutamate secretion
regulation of synaptic vesicle fusion to presynaptic membrane
regulation of SNARE complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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