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Invitrogen
MUSK Polyclonal Antibody
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MUSK Antibody (PA5-96178) in WB
Western blot analysis of MUSK in mouse skeletal muscle. Samples were incubated with MUSK Polyclonal antibody (Product # PA5-96178) using a dilution of 1:500, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
PA5-96178
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 424-783 of human MUSK (NP_0011597521)
Conjugate
Form
Liquid
Concentration
4.01 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2807980
Product Specific Information
Immunogen sequence: LTITTLYCCR RRKQWKNKKR ESAAVTLTTL PSELLLDRLH PNPMYQRMPL LLNPKLLSLE YPRNNIEYVR DIGEGAFGRV FQARAPGLLP YEPFTMVAVK MLKEEASADM QADFQREAAL MAEFDNPNIV KLLGVCAVGK PMCLLFEYMA YGDLNEFLRS MSPHTVCSLS HSDLSMRAQV SSPGPPPLSC AEQLCIARQV AAGMAYLSER KFVHRDLATR NCLVGENMVV KIADFGLSRN IYSADYYKAN ENDAIPIRWM PPESIFYNRY TTESDVWAYG VVLWEIFSYG LQPYYGMAHE EVIYYVRDGN ILSCPENCPV ELYNLMRLCW SKLPADRPSF TSIHRILERM CERAEGTVSV; Positive Samples: SW480; Cellular Location: Cell junction, Single-pass type I membrane protein, postsynaptic cell membrane, synapse
Target Information
MUSK plays an important and selective role in many aspects of skeletal muscle development and function through the initial step of postsynaptic differentiation and formation of end-plate bands in cooperation with Rapsyn. Communication between cells is often mediated by receptors on the surface of the target cell that are triggered by specific ligands released by other cells. Receptor tyrosine kinase activity is strictly regulated by the binding of the appropriate ligand to the extracellular active site of the receptor. MuSK has been shown to be part of the agrin signaling complex and plays an important role in the development and architectural maintenance of the neuromuscular junction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC126323; MGC126324; muscle localized kinase 2; muscle, skeletal receptor tyrosine protein kinase; Muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific protein kinase secretory isoform; muscle-specific tyrosine protein kinase receptor; Muscle-specific tyrosine-protein kinase receptor; MuSK; RP23-170A3.1
Gene Aliases: Mdk4; Mlk; Musk; Nsk1; Nsk2; Nsk3
UniProt ID: (Mouse) Q61006
Entrez Gene ID: (Mouse) 18198
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
PDZ domain binding
positive regulation of protein phosphorylation
regulation of transcription, DNA-templated
protein phosphorylation
signal transduction
multicellular organism development
neuromuscular junction development
memory
regulation of synaptic growth at neuromuscular junction
positive regulation of gene expression
negative regulation of gene expression
phosphorylation
peptidyl-tyrosine phosphorylation
cell differentiation
positive regulation of synaptic transmission, cholinergic
receptor clustering
positive regulation of neuron apoptotic process
positive regulation of synaptic growth at neuromuscular junction
protein autophosphorylation
positive regulation of peptidyl-tyrosine phosphorylation
response to electrical stimulus
long-term synaptic potentiation
skeletal muscle acetylcholine-gated channel clustering
positive regulation of protein geranylgeranylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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