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Product Details
PA5-36985
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 414-459 of human MX2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2553850
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 82 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Members of the Dynamin family include GTPase, microtubule-associated proteins that are involved in cellular trafficking, including microtubule bundling and endocytosis. Mx1, also known as MxA, an interferon (IFN)-induced protein, acquires a high degree of resistance to influenza A virus and the rhabdo-virus vesicular stomatitis virus (VSV), which suggests that Mx1 plays an active role against influenza virus and the rhabdovirus VSV. Mx1 is a cytoplasmic protein that is 63% identical to the Mx2 protein, which lacks antiviral activity. Mx2 is also known as MxB and is localized at the cytoplasmic face of nuclear pores. Mx2 expression is not interferon-dependent and this protein is thought to regulate the efficiency and/or kinetics of nuclear import, a function which may have been usurped by its antiviral relatives.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Interferon-induced GTP-binding protein Mx2; interferon-induced GTP-binding protein Mx3; Interferon-regulated resistance GTP-binding protein MxB; MX dynamin-like GTPase 2; myxovirus (influenza virus) resistance 2; myxovirus (influenza virus) resistance 3; Myxovirus resistance protein 2; myxovirus resistance protein 3; p78-related protein; protein MxB; second interferon-induced protein p78
Gene Aliases: AI528743; Mx-2; MX2; Mx3; MXB
UniProt ID: (Human) P20592, (Mouse) Q9WVP9
Entrez Gene ID: (Human) 4600, (Rat) 286918, (Mouse) 17858
metabolic process
response to virus
response to type I interferon
negative regulation of viral genome replication
innate immune response
defense response to virus
defense response
protein transport
response to interferon-alpha
regulation of nucleocytoplasmic transport
mRNA transport
regulation of cell cycle
type I interferon signaling pathway
immune system process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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