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Proteintech
MYBBP1A Polyclonal Antibody
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Product Details
14524-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MYBBP1A Fusion Protein Ag6008 (979-1328 aa encoded by BC050546)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: STALSSFLT KRNSPLTVPM FLSLFSRHPV LCQSLLPILV QHITGPVRPR RQACLLLQKT LSMREVRSCF EDPEWKQLMG QVLAKVTENL RVLGEAQTKA QHQQALSSLE LLNVLFRTCK HEKLTLDLTV LLGVLQGQQQ SLQQGAHSTG SSRLHDLYWQ AMKTLGVQRP KLEKKDAKEI PSATQSPISK KRKKKGFLPE TKKRKKRKSE DGTPAEDGTP AATGGSQPPS MGRKKRNRTK AKVPAQANGT PTTKSPAPGA PTRSPSTPAK SPKLQKKNQK PSQVNGAPGS PTEPAGQKQH QKALPKKGVL GKSPLSALAR KKARLSLVIR SPSLLQSGAK KKAQVRKAGK P (979-1328 aa encoded by BC050546)
Target Information
The Myb family of transcription factors, which includes the structurally related A-, B-, and c-Myb genes, regulate differentiation, cellular growth and transactivating gene expression. c-Myb plays an essential role in controlling the proliferation and differentiation of hematopoietic cells, cellular levels of c-Myb decreasing as cells reach terminal differentiation. Myb-binding protein 1A (MYBBP1A) is a novel nuclear protein localized predominantly, but not exclusively, in nucleoli. Although initially isolated as a c-Myb-interacting protein, MYBBP1A is expressed ubiquitously, and associates with a number of different transcription factors. MYBBP1A associates with the aromatic hydrocarbon receptor (AhR), enhancing transactivation and increasing AhR-dependent gene expression. MYBBP1A is a powerful negative regulator of PPAR gamma coactivator 1 alpha (PGC-1 alpha) by p38 MAPK and also acts as a nucleocytoplasmic shuttling protein that utilizes CRM1-dependent and independent nuclear export pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MYB binding protein (P160) 1a; Myb-binding protein 1A; p53-activated protein-2
Gene Aliases: MYBBP1A; P160; PAP2
UniProt ID: (Human) Q9BQG0
Entrez Gene ID: (Human) 10514
osteoblast differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
nucleocytoplasmic transport
respiratory electron transport chain
circadian regulation of gene expression
cellular response to glucose starvation
positive regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
positive regulation of cell cycle arrest
DNA biosynthetic process
intrinsic apoptotic signaling pathway by p53 class mediator
positive regulation of anoikis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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