Proteintech

MYH7 Polyclonal Antibody

MYH7 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MYH7 Antibody (22280-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using 22280-1-AP (MYH7-specific antibody at dilution of 1:50 (under 40x lens).

MYH7 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

MYH7 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

22280-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:600-1:2,000

View 30 publications 30 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (MISC)

View 3 publications 3 publications

Not applicable (N/A)

View 5 publications 5 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.66 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can specifically recognize endogenous MYH7, not cross-reacting with other MHCs.

Target Information

Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

G9a inhibition promotes the formation of pacemaker-like cells by reducing the enrichment of H3K9me2 in the HCN4 promoter region.

Molecular medicine reports

Xu P,Jin K,Zhou J,Gu J,Gu X,Dong L,Sun X

Wed Feb 01 00:00:00 UTC 2023

Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp.

bioRxiv : the preprint server for biology

Neininger-Castro AC,Hayes JB,Sanchez ZC,Taneja N,Fenix AM,Moparthi S,Vassilopoulos S,Burnette DT

Fri Oct 06 00:00:00 UTC 2023

Identification of circRNA-miRNA-mRNA regulatory network and its role in cardiac hypertrophy.

PloS one

Gong K,Yang K,Xie T,Luo Y,Guo H,Tan Z,Chen J,Wu Q,Gong Y,Wei L,Luo J,Yao Y,Yang Y,Xie L

Mon Mar 27 00:00:00 UTC 2023

Super-enhancer-driven lncRNA Snhg7 aggravates cardiac hypertrophy via Tbx5/GLS2/ferroptosis axis.

European journal of pharmacology

Zhang Q,Song C,Zhang M,Liu Y,Wang L,Xie Y,Qi H,Ba L,Shi P,Cao Y,Sun H

Tue Aug 15 00:00:00 UTC 2023

Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation.

Cell reports

Zou J,Wang W,Lu Y,Ayala J,Dong K,Zhou H,Wang J,Chen W,Weintraub NL,Zhou J,Li J,Su H

Tue Jan 31 00:00:00 UTC 2023

Sodium Butyrate Ameliorates Type 2 Diabetes-Related Sarcopenia Through IL-33-Independent ILC2s/IL-13/STAT3 Signaling Pathway.

Journal of inflammation research

Cao Y,Li Y,Han W,Jia X,Zhu P,Wei B,Cong X,Wang Z

Sat Feb 04 00:00:00 UTC 2023

GLUT4 mediates the protective function of gastrodin against pressure overload-induced cardiac hypertrophy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhang M,Tan Y,Song Y,Zhu M,Zhang B,Chen C,Liu Y,Shi L,Cui J,Shan W,Jia Z,Feng L,Cao G,Yi W,Sun Y

Mon May 01 00:00:00 UTC 2023

Dectin-1 deficiency alleviates diabetic cardiomyopathy by attenuating macrophage-mediated inflammatory response.

Biochimica et biophysica acta. Molecular basis of disease

Yang N,Wang M,Lin K,Wang M,Xu D,Han X,Zhao X,Wang Y,Wu G,Luo W,Liang G,Shan P

Tue Aug 01 00:00:00 UTC 2023

Hgs Deficiency Caused Restrictive Cardiomyopathy via Disrupting Proteostasis.

International journal of biological sciences

Li Z,Wang T,Xin C,Song Y,Kong J,Xu J,Liu Q,Teng Y,Hou N,Cheng X,Yang G,Liu W,Zhou B,Zhang Y,Yang X,Wang J

Fri Dec 23 00:00:00 UTC 2022

An EGFP Knock-in Zebrafish Experimental Model Used in Evaluation of the Amantadine Drug Safety During Early Cardiogenesis.

Frontiers in cardiovascular medicine

Ouyang S,Qin WM,Niu YJ,Ding YH,Deng Y

Sat Jul 16 00:00:00 UTC 2022

ANGPTL8 is a negative regulator in pathological cardiac hypertrophy.

Cell death & disease

Hu L,Wei J,Zhang Y,Wang Z,Tang J,Tang J,Gao Y,Zhang X,Li Y,Liu Y,Ma S,Guo X,Zhang Q

Mon Jul 18 00:00:00 UTC 2022

Functional analysis reveals that Tinagl1 is required for normal muscle development in mice through the activation of ERK signaling.

Biochimica et biophysica acta. Molecular cell research

Sato Y,Kawashima K,Fukui E,Matsumoto H,Yoshizawa F,Sato Y

Thu Sep 01 00:00:00 UTC 2022

Loss of Myostatin Alters Mitochondrial Oxidative Phosphorylation, TCA Cycle Activity, and ATP Production in Skeletal Muscle.

International journal of molecular sciences

Wang X,Wei Z,Gu M,Zhu L,Hai C,Di A,Wu D,Bai C,Su G,Liu X,Yang L,Li G

Sun Dec 11 00:00:00 UTC 2022

Exercise-derived peptide protects against pathological cardiac remodeling.

EBioMedicine

Yin A,Yuan R,Xiao Q,Zhang W,Xu K,Yang X,Yang W,Xu L,Wang X,Zhuang F,Li Y,Cai Z,Sun Z,Zhou B,He B,Shen L

Mon Aug 01 00:00:00 UTC 2022

Changes in nuclear pore numbers control nuclear import and stress response of mouse hearts.

Developmental cell

Han L,Mich-Basso JD,Li Y,Ammanamanchi N,Xu J,Bargaje AP,Liu H,Wu L,Jeong JH,Franks J,Stolz DB,Wu YL,Rajasundaram D,Liu Y,Kühn B

Mon Oct 24 00:00:00 UTC 2022

Engineering of thick human functional myocardium via static stretching and electrical stimulation.

iScience

Pretorius D,Kahn-Krell AM,LaBarge WC,Lou X,Zhang J

Fri Mar 18 00:00:00 UTC 2022

Scutellarein protects against cardiac hypertrophy via suppressing TRAF2/NF-κB signaling pathway.

Molecular biology reports

Shi X,Hu Y,Jiang Y,Wu J,Zhang C,Zhang J,Wu S,Wu Y,Dong W,Li J

Tue Mar 01 00:00:00 UTC 2022

Amelioration of circadian disruption and calcium-handling protein defects by choline alleviates cardiac remodeling in abdominal aorta coarctation rats.

Laboratory investigation; a journal of technical methods and pathology

He X,Yang S,Deng J,Wu Q,Zang WJ

Thu Jul 01 00:00:00 UTC 2021

Amelioration of circadian disruption and calcium-handling protein defects by choline alleviates cardiac remodeling in abdominal aorta coarctation rats.

Laboratory investigation; a journal of technical methods and pathology

He X,Yang S,Deng J,Wu Q,Zang WJ

Thu Jul 01 00:00:00 UTC 2021

YTHDF2 alleviates cardiac hypertrophy via regulating Myh7 mRNA decoy.

Cell & bioscience

Xu H,Wang Z,Chen M,Zhao W,Tao T,Ma L,Ni Y,Li W

Thu Jul 15 00:00:00 UTC 2021

Generation of a homozygous MYH7 gene knockout human embryonic stem cell line (WAe009-A-69) using an episomal vector-based CRISPR/Cas9 system.

Stem cell research

Guo T,Jiang Y,Song Y,Ma S,Chang Y,Zhang S,Wang H,Dong T,Jiang H,Lu W

Wed Dec 01 00:00:00 UTC 2021

Sleeve Gastrectomy Ameliorates Diabetes-Induced Cardiac Hypertrophy Correlates With the MAPK Signaling Pathway.

Frontiers in physiology

Xu Q,Ding H,Li S,Dong S,Li L,Shi B,Zhong M,Zhang G

Sat Dec 04 00:00:00 UTC 2021

TANK Promotes Pressure Overload Induced Cardiac Hypertrophy via Activating AKT Signaling Pathway.

Frontiers in cardiovascular medicine

Pang Y,Ma M,Wang D,Li X,Jiang L

Tue Sep 21 00:00:00 UTC 2021

Comprehensive histological investigation of age-related changes in dermal extracellular matrix and muscle fibers in the upper lip vermilion.

International journal of cosmetic science

Gomi T,Imamura T

Sat Aug 01 00:00:00 UTC 2020

MYH7B variants cause hypertrophic cardiomyopathy by activating the CaMK-signaling pathway.

Science China. Life sciences

Chen P,Li Z,Nie J,Wang H,Yu B,Wen Z,Sun Y,Shi X,Jin L,Wang DW

Tue Sep 01 00:00:00 UTC 2020

LonP1 regulates mitochondrial network remodeling through the PINK1/Parkin pathway during myoblast differentiation.

American journal of physiology. Cell physiology

Huang S,Wang X,Yu J,Tian Y,Yang C,Chen Y,Chen H,Ge H

Tue Dec 01 00:00:00 UTC 2020

An MRTF-A-Sp1-PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy.

Frontiers in cell and developmental biology

Wu T,Wang H,Xin X,Yang J,Hou Y,Fang M,Lu X,Xu Y

Fri Jul 16 00:00:00 UTC 2021

An MRTF-A-Sp1-PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy.

Frontiers in cell and developmental biology

Wu T,Wang H,Xin X,Yang J,Hou Y,Fang M,Lu X,Xu Y

Fri Jul 16 00:00:00 UTC 2021

Hyperglycemia-Driven Inhibition of AMP-Activated Protein Kinase α2 Induces Diabetic Cardiomyopathy by Promoting Mitochondria-Associated Endoplasmic Reticulum Membranes In Vivo.

Circulation

Wu S,Lu Q,Ding Y,Wu Y,Qiu Y,Wang P,Mao X,Huang K,Xie Z,Zou MH

Tue Apr 16 00:00:00 UTC 2019

Effect of Hypoxia on the Muscle Fiber Switching Signal Pathways CnA/NFATc1 and Myostatin in Mouse Myocytes.

Acta histochemica

Lixin L,Juan W,Yun B,Jingwei L,Xiuju Y,Xiaomao L,Zhiwei Z,Xiaoyan H,Yanjun D,Hongquan L,Haidong W

Mon Jul 01 00:00:00 UTC 2019

Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions.

Developmental cell

Chopra A,Kutys ML,Zhang K,Polacheck WJ,Sheng CC,Luu RJ,Eyckmans J,Hinson JT,Seidman JG,Seidman CE,Chen CS

Mon Jan 08 00:00:00 UTC 2018

Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions.

Developmental cell

Chopra A,Kutys ML,Zhang K,Polacheck WJ,Sheng CC,Luu RJ,Eyckmans J,Hinson JT,Seidman JG,Seidman CE,Chen CS

Mon Jan 08 00:00:00 UTC 2018

Sphingosine-1-phosphate ameliorates the cardiac hypertrophic response through inhibiting the activity of histone deacetylase-2.

International journal of molecular medicine

Yan H,Yi S,Zhuang H,Wu L,Wang DW,Jiang J

Thu Mar 01 00:00:00 UTC 2018

Proteomics of acute heart failure in a rat post-myocardial infarction model.

Molecular medicine reports

Guo Y,Cui L,Jiang S,Zhang A,Jiang S

Tue Aug 01 00:00:00 UTC 2017

Proteomics of acute heart failure in a rat post-myocardial infarction model.

Molecular medicine reports

Guo Y,Cui L,Jiang S,Zhang A,Jiang S

Tue Aug 01 00:00:00 UTC 2017

Proteomics of acute heart failure in a rat post-myocardial infarction model.

Molecular medicine reports

Guo Y,Cui L,Jiang S,Zhang A,Jiang S

Tue Aug 01 00:00:00 UTC 2017

Proteomics of acute heart failure in a rat post-myocardial infarction model.

Molecular medicine reports

Guo Y,Cui L,Jiang S,Zhang A,Jiang S

Tue Aug 01 00:00:00 UTC 2017

Roles of Mitogen-Activating Protein Kinase Kinase Kinase Kinase-3 (MAP4K3) in Preterm Skeletal Muscle Satellite Cell Myogenesis and Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Regulation.

Medical science monitor : international medical journal of experimental and clinical research

Guo CY,Yu MX,Dai JM,Pan SN,Lu ZT,Qiu XS,Zhuang SQ

Fri Jul 21 00:00:00 UTC 2017

Medical science monitor : international medical journal of experimental and clinical research

Guo CY,Yu MX,Dai JM,Pan SN,Lu ZT,Qiu XS,Zhuang SQ

Fri Jul 21 00:00:00 UTC 2017

Medical science monitor : international medical journal of experimental and clinical research

Guo CY,Yu MX,Dai JM,Pan SN,Lu ZT,Qiu XS,Zhuang SQ

Fri Jul 21 00:00:00 UTC 2017

Medical science monitor : international medical journal of experimental and clinical research

Guo CY,Yu MX,Dai JM,Pan SN,Lu ZT,Qiu XS,Zhuang SQ

Fri Jul 21 00:00:00 UTC 2017

Oral quercetin administration transiently protects respiratory function in dystrophin-deficient mice.

The Journal of physiology

Selsby JT,Ballmann CG,Spaulding HR,Ross JW,Quindry JC

Sat Oct 15 00:00:00 UTC 2016

Oral quercetin administration transiently protects respiratory function in dystrophin-deficient mice.

The Journal of physiology

Selsby JT,Ballmann CG,Spaulding HR,Ross JW,Quindry JC

Sat Oct 15 00:00:00 UTC 2016

Excess Imidacloprid Exposure Causes the Heart Tube Malformation of Chick Embryos.

Journal of agricultural and food chemistry

Gao LR,Li S,Zhang J,Liang C,Chen EN,Zhang SY,Chuai M,Bao YP,Wang G,Yang X

Wed Nov 30 00:00:00 UTC 2016

Excess Imidacloprid Exposure Causes the Heart Tube Malformation of Chick Embryos.

Journal of agricultural and food chemistry

Gao LR,Li S,Zhang J,Liang C,Chen EN,Zhang SY,Chuai M,Bao YP,Wang G,Yang X

Wed Nov 30 00:00:00 UTC 2016

HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.

Science (New York, N.Y.)

Hinson JT,Chopra A,Nafissi N,Polacheck WJ,Benson CC,Swist S,Gorham J,Yang L,Schafer S,Sheng CC,Haghighi A,Homsy J,Hubner N,Church G,Cook SA,Linke WA,Chen CS,Seidman JG,Seidman CE

Fri Aug 28 00:00:00 UTC 2015

HEART DISEASE. Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy.

Science (New York, N.Y.)

Hinson JT,Chopra A,Nafissi N,Polacheck WJ,Benson CC,Swist S,Gorham J,Yang L,Schafer S,Sheng CC,Haghighi A,Homsy J,Hubner N,Church G,Cook SA,Linke WA,Chen CS,Seidman JG,Seidman CE

Fri Aug 28 00:00:00 UTC 2015

Platelet-derived growth factor regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1.

Biochemical and biophysical research communications

Ha JM,Yun SJ,Kim YW,Jin SY,Lee HS,Song SH,Shin HK,Bae SS

Fri Aug 14 00:00:00 UTC 2015

Platelet-derived growth factor regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1.

Biochemical and biophysical research communications

Ha JM,Yun SJ,Kim YW,Jin SY,Lee HS,Song SH,Shin HK,Bae SS

Fri Aug 14 00:00:00 UTC 2015

MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells.

FEBS letters

Zeng Y,Pan Y,Liu H,Kang K,Wu Y,Hui G,Peng W,Ramchandran R,Raj JU,Gou D

Sat Dec 20 00:00:00 UTC 2014

MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells.

FEBS letters

Zeng Y,Pan Y,Liu H,Kang K,Wu Y,Hui G,Peng W,Ramchandran R,Raj JU,Gou D

Sat Dec 20 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: cardiac muscle myosin heavy chain 7 beta; cardiac myosin heavy chain beta isoform; MYH-beta/slow; MyHC-beta; MyHC-slow; myopathy, distal 1; Myosin heavy chain 7; Myosin heavy chain slow isoform; Myosin heavy chain, cardiac muscle beta isoform; myosin heavy chain, cardiac muscle, fetal; myosin, heavy polypeptide 7, cardiac muscle, beta; Myosin-7; rhabdomyosarcoma antigen MU-RMS-40.7A

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Gene Aliases: B-MHC; beta-MHC; CMD1S; CMH1; MPD1; MYH7; Myhc-b; MyHC-I; MYHCB; SPMD; SPMM

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UniProt ID: (Human) P12883, (Mouse) Q91Z83

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Entrez Gene ID: (Human) 4625, (Mouse) 140781

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Function(s)

microfilament motor activity actin binding protein binding calmodulin binding ATP binding ATPase activity actin-dependent ATPase activity protein homodimerization activity protein heterodimerization activity nucleotide binding motor activity

Process(es)

regulation of the force of heart contraction regulation of heart rate skeletal muscle contraction muscle contraction striated muscle contraction adult heart development metabolic process regulation of the force of skeletal muscle contraction transition between fast and slow fiber muscle filament sliding regulation of slow-twitch skeletal muscle fiber contraction ATP metabolic process ventricular cardiac muscle tissue morphogenesis cardiac muscle contraction

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MYH7 Polyclonal Antibody

MYH7 Antibody (22280-1-AP) in IHC (P)

Product Details

22280-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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