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Invitrogen
MYH7 Polyclonal Antibody
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MYH7 Antibody (PA5-119294) in IHC (P)
Immunohistochemistry analysis of Cardiac Myosin Heavy Chain in paraffin-embedded Human Cerebrum tissue. Samples were incubated with polyclonal antibody (Product # PA5-119294) at a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.
Product Details
PA5-119294
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein Myosin Heavy Chain 7B, Cardiac Muscle Beta. The antigen corresponds to amino acid range 829-1106 of the target protein.
Conjugate
Form
Liquid
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2903792
Target Information
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta-myosin heavy chain; cardiac muscle myosin heavy chain 7 beta; MyHC-beta; MyHC-slow; myopathy, distal 1; Myosin heavy chain 7; Myosin heavy chain slow isoform; Myosin heavy chain, cardiac muscle beta isoform; myosin, heavy polypeptide 7, cardiac muscle, beta; Myosin-7; rhabdomyosarcoma antigen MU-RMS-40.7A
Gene Aliases: CMD1S; CMH1; MPD1; MYH7; MYHCB; SPMD; SPMM
UniProt ID: (Human) P12883, (Pig) P79293
Entrez Gene ID: (Human) 4625, (Pig) 396860
regulation of the force of heart contraction
regulation of heart rate
skeletal muscle contraction
muscle contraction
striated muscle contraction
adult heart development
regulation of the force of skeletal muscle contraction
transition between fast and slow fiber
muscle filament sliding
regulation of slow-twitch skeletal muscle fiber contraction
ATP metabolic process
ventricular cardiac muscle tissue morphogenesis
cardiac muscle contraction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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