Proteintech

MYL7 Polyclonal Antibody

MYL7 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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MYL7 Antibody (17283-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Mouse heart tissue slide using (Product # 17283-1-AP) MYL7 antibody at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

MYL7 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

MYL7 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

17283-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 10 publications 10 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MYL7 Fusion Protein Ag11058 (1-175 aa encoded by BC027915)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.36 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MASRKAGTR GKVAATKQAQ RGSSNVFSMF EQAQIQEFKE AFSCIDQNRD GIICKADLRE TYSQLGKVSV PEEELDAMLQ EGKGPINFTV FLTLFGEKLN GTDPEEAILS AFRMFDPSGK GVVNKDEFKQ LLLTQADKFS PAEVEQMFAL TPMDLAGNID YKSLCYIITH GDEKEE (1-175 aa encoded by B C027915)

Target Information

Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage.

Development (Cambridge, England)

Tsaytler P,Liu J,Blaess G,Schifferl D,Veenvliet JV,Wittler L,Timmermann B,Herrmann BG,Koch F

Mon May 15 00:00:00 UTC 2023

Neddylation is required for perinatal cardiac development through stimulation of metabolic maturation.

Cell reports

Zou J,Wang W,Lu Y,Ayala J,Dong K,Zhou H,Wang J,Chen W,Weintraub NL,Zhou J,Li J,Su H

Tue Jan 31 00:00:00 UTC 2023

1-Deoxynojirimycin promotes cardiac function and rescues mitochondrial cristae in mitochondrial hypertrophic cardiomyopathy.

The Journal of clinical investigation

Zhuang Q,Guo F,Fu L,Dong Y,Xie S,Ding X,Hu S,Zhou XD,Jiang Y,Zhou H,Qiu Y,Lei Z,Li M,Cai H,Fan M,Sang L,Fu Y,Zhang D,Lin A,Li X,Kunath T,Zhou R,Liang P,Liu Z,Yan Q

Mon Jul 17 00:00:00 UTC 2023

Cellular Phenotypic Transformation in Heart Failure Caused by Coronary Heart Disease and Dilated Cardiomyopathy: Delineating at Single-Cell Level.

Biomedicines

Zhu L,Wang W,Ren C,Wang Y,Zhang G,Liu J,Wang W

Tue Feb 08 00:00:00 UTC 2022

Cellular Phenotypic Transformation in Heart Failure Caused by Coronary Heart Disease and Dilated Cardiomyopathy: Delineating at Single-Cell Level.

Biomedicines

Zhu L,Wang W,Ren C,Wang Y,Zhang G,Liu J,Wang W

Tue Feb 08 00:00:00 UTC 2022

MYOCD is Required for Cardiomyocyte-like Cells Induction from Human Urine Cells and Fibroblasts Through Remodeling Chromatin.

Stem cell reviews and reports

Zhang X,Chen L,Huang X,Chen H,Cai B,Qin Y,Chen Y,Ou S,Li X,Wu Z,Feng Z,Zeng M,Guo W,Li H,Zhou C,Yu S,Pan M,Liu J,Kang K,Cao S,Pei D

Sat Oct 01 00:00:00 UTC 2022

Vasorin deficiency leads to cardiac hypertrophy by targeting MYL7 in young mice.

Journal of cellular and molecular medicine

Sun J,Guo X,Yu P,Liang J,Mo Z,Zhang M,Yang L,Huang X,Hu B,Liu J,Ouyang Y,He M

Sat Jan 01 00:00:00 UTC 2022

Vasorin deficiency leads to cardiac hypertrophy by targeting MYL7 in young mice.

Journal of cellular and molecular medicine

Sun J,Guo X,Yu P,Liang J,Mo Z,Zhang M,Yang L,Huang X,Hu B,Liu J,Ouyang Y,He M

Sat Jan 01 00:00:00 UTC 2022

Induction of Stem-Cell-Derived Cardiomyogenesis by Fibroblast Growth Factor 10 (FGF10) and Its Interplay with Cardiotrophin-1 (CT-1).

Biology

Khosravi F,Ahmadvand N,Wartenberg M,Sauer H

Wed Mar 30 00:00:00 UTC 2022

Appropriate Exogenous Expression Stoichiometry of GATA4 as an Important Factor for Cardiac Reprogramming of Human Dermal Fibroblasts.

Cellular reprogramming

Zhang X,Zhang Q,Chen L,Cai B,Zeng M,Ou S,Chen Y,Feng Z,Chen H,Cao S,Kang K

Sat Oct 01 00:00:00 UTC 2022

HiPS-Endothelial Cells Acquire Cardiac Endothelial Phenotype in Co-culture With hiPS-Cardiomyocytes.

Frontiers in cell and developmental biology

Helle E,Ampuja M,Dainis A,Antola L,Temmes E,Tolvanen E,Mervaala E,Kivelä R

Tue Aug 24 00:00:00 UTC 2021

Thymosin β4 increases cardiac cell proliferation, cell engraftment, and the reparative potency of human induced-pluripotent stem cell-derived cardiomyocytes in a porcine model of acute myocardial infarction.

Theranostics

Tan SH,Loo SJ,Gao Y,Tao ZH,Su LP,Wang CX,Zhang SL,Mu YH,Cui YH,Abdurrachim D,Wang WH,Lalic J,Lim KC,Bu J,Tan RS,Lee TH,Zhang J,Ye L

Mon Aug 23 00:00:00 UTC 2021

Angiopoietin-1 enhanced myocyte mitosis, engraftment, and the reparability of hiPSC-CMs for treatment of myocardial infarction.

Cardiovascular research

Tao Z,Loo S,Su L,Tan S,Tee G,Gan SU,Zhang J,Chen X,Ye L

Tue May 25 00:00:00 UTC 2021

Chamber-Specific Protein Expression during Direct Cardiac Reprogramming.

Cells

Zhang Z,Villalpando J,Zhang W,Nam YJ

Wed Jun 16 00:00:00 UTC 2021

High content analysis identifies unique morphological features of reprogrammed cardiomyocytes.

Scientific reports

Sutcliffe MD,Tan PM,Fernandez-Perez A,Nam YJ,Munshi NV,Saucerman JJ

Fri Jan 19 00:00:00 UTC 2018

High content analysis identifies unique morphological features of reprogrammed cardiomyocytes.

Scientific reports

Sutcliffe MD,Tan PM,Fernandez-Perez A,Nam YJ,Munshi NV,Saucerman JJ

Fri Jan 19 00:00:00 UTC 2018

Mitochondrial Dysfunctions Contribute to Hypertrophic Cardiomyopathy in Patient iPSC-Derived Cardiomyocytes with MT-RNR2 Mutation.

Stem cell reports

Li S,Pan H,Tan C,Sun Y,Song Y,Zhang X,Yang W,Wang X,Li D,Dai Y,Ma Q,Xu C,Zhu X,Kang L,Fu Y,Xu X,Shu J,Zhou N,Han F,Qin D,Huang W,Liu Z,Yan Q

Tue Mar 13 00:00:00 UTC 2018

Mitochondrial Dysfunctions Contribute to Hypertrophic Cardiomyopathy in Patient iPSC-Derived Cardiomyocytes with MT-RNR2 Mutation.

Stem cell reports

Li S,Pan H,Tan C,Sun Y,Song Y,Zhang X,Yang W,Wang X,Li D,Dai Y,Ma Q,Xu C,Zhu X,Kang L,Fu Y,Xu X,Shu J,Zhou N,Han F,Qin D,Huang W,Liu Z,Yan Q

Tue Mar 13 00:00:00 UTC 2018

High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling.

Nature communications

Zhao Y,Londono P,Cao Y,Sharpe EJ,Proenza C,O'Rourke R,Jones KL,Jeong MY,Walker LA,Buttrick PM,McKinsey TA,Song K

Thu Sep 10 00:00:00 UTC 2015

High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling.

Nature communications

Zhao Y,Londono P,Cao Y,Sharpe EJ,Proenza C,O'Rourke R,Jones KL,Jeong MY,Walker LA,Buttrick PM,McKinsey TA,Song K

Thu Sep 10 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: MLC-2a; MLC2a; myosin light chain 2a; myosin light chain, regulatory A; Myosin regulatory light chain 2, atrial isoform; Myosin regulatory light chain 7; myosin, light chain 7, regulatory; myosin, light polypeptide 7, regulatory

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Gene Aliases: MLC-2alpha; MLC2a; MYL2A; MYL7; MYLC2A; RLC-A

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UniProt ID: (Human) Q01449, (Mouse) Q9QVP4

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Entrez Gene ID: (Human) 58498, (Rat) 289759, (Mouse) 17898

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Function(s)

calcium ion binding protein binding metal ion binding

Process(es)

muscle contraction

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MYL7 Polyclonal Antibody

MYL7 Antibody (17283-1-AP) in IHC (P)

Product Details

17283-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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