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The antibody can recognize isoform 1, isoform 2 and isoform 3 of MYO16.
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: myo16; MYO16 variant protein; myosin heavy chain Myr 8; myosin-XVI; neuronal tyrosine phosphorylated adaptor for phosphoinositide 3-kinase adaptor 3; Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3; neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 3; protein phosphatase 1, regulatory subunit 107; Unconventional myosin-16; Unconventional myosin-XVI
Gene Aliases: BM140241; C230040D10Rik; Gm1105; KIAA0865; mKIAA0865; MYAP3; MYO16; MYO16B; MYR8; NYAP3; PPP1R107
UniProt ID: (Human) Q9Y6X6, (Mouse) Q5DU14
Entrez Gene ID: (Human) 23026, (Mouse) 244281
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