Proteintech

MYO18A Polyclonal Antibody

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MYO18A Antibody (14611-1-AP) in WB

Neuro-2a cells were subjected to SDS PAGE followed by western blot with 14611-1-AP (MYO18A Antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

MYO18A Antibody in Immunoprecipitation (IP)

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Product Details

14611-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

Assay-dependent

View 4 publications 4 publications

Flow Cytometry (Flow)

Assay-dependent

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MYO18A Fusion Protein Ag6185 (1601-2002 aa encoded by BC039612)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TLSDQVNRR DFESEKRLRK DLKRTKALLA DAQLMLDHLK NSAPSKREIA QLKNQLEESE FTCAAAVKAR KAMEVEIEDL HLQIDDIAKA KTALEEQLSR LQREKNEIQN RLEEDQEDMN ELMKKHKAAV AQASRDLAQI NDLQAQLEEA NKEKQELQEK LQALQSQVEF LEQSMVDKSL VSRQEAKIRE LETRLEFERT QVKRLESLAS RLKENMEKLT EERDQRIAAE NREKEQNKRL QRQLRDTKEE MGELARKEAE ASRKKHELEM DLESLEAANQ SLQADLKLAF KRIGDLQAAI EDEMESDENE DLINSEGDSD VDSELEDRVD GVKSWLSKNK GPSKAASDDG SLKSSSPTSY WKSLAPDRSD DEHDPLDNTS RPRYSHSYLS DSDTEAKLTE TNA (1601-2002 aa encoded by BC039612)

Target Information

MYO18A may link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

GIPC3 couples to MYO6 and PDZ domain proteins and shapes the hair cell apical region.

bioRxiv : the preprint server for biology

Chatterjee P,Morgan CP,Krey JF,Benson C,Goldsmith J,Bateschell M,Ricci AJ,Barr-Gillespie PG

Wed Mar 01 00:00:00 UTC 2023

GIPC3 couples to MYO6 and PDZ domain proteins, and shapes the hair cell apical region.

Journal of cell science

Chatterjee P,Morgan CP,Krey JF,Benson C,Goldsmith J,Bateschell M,Ricci AJ,Barr-Gillespie PG

Mon May 15 00:00:00 UTC 2023

The Smad4-MYO18A-PP1A complex regulates β-catenin phosphorylation and pemigatinib resistance by inhibiting PAK1 in cholangiocarcinoma.

Cell death and differentiation

Liu J,Ren G,Li K,Liu Z,Wang Y,Chen T,Mu W,Yang X,Li X,Shi A,Zhao W,Xu B,Chang J,Guo S,Pan C,Zhou T,Zhang Z,Xu Y

Fri Apr 01 00:00:00 UTC 2022

The Smad4-MYO18A-PP1A complex regulates β-catenin phosphorylation and pemigatinib resistance by inhibiting PAK1 in cholangiocarcinoma.

Cell death and differentiation

Liu J,Ren G,Li K,Liu Z,Wang Y,Chen T,Mu W,Yang X,Li X,Shi A,Zhao W,Xu B,Chang J,Guo S,Pan C,Zhou T,Zhang Z,Xu Y

Fri Apr 01 00:00:00 UTC 2022

A protumorigenic secretory pathway activated by p53 deficiency in lung adenocarcinoma.

The Journal of clinical investigation

Tan X,Shi L,Banerjee P,Liu X,Guo HF,Yu J,Bota-Rabassedas N,Rodriguez BL,Gibbons DL,Russell WK,Creighton CJ,Kurie JM

Mon Jan 04 00:00:00 UTC 2021

Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages.

Immunobiology

Yau E,Chen Y,Song C,Webb J,Carillo M,Kawasawa YI,Tang Z,Takahashi Y,Umstead TM,Dovat S,Chroneos ZC

Mon Nov 01 00:00:00 UTC 2021

Pushing myelination - developmental regulation of myosin expression drives oligodendrocyte morphological differentiation.

Journal of cell science

Domingues HS,Urbanski MM,Macedo-Ribeiro S,Almaktari A,Irfan A,Hernandez Y,Wang H,Relvas JB,Rubinstein B,Melendez-Vasquez CV,Pinto IM

Wed Aug 05 00:00:00 UTC 2020

Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding.

Diabetes

Tran DT,Pottekat A,Mir SA,Loguercio S,Jang I,Campos AR,Scully KM,Lahmy R,Liu M,Arvan P,Balch WE,Kaufman RJ,Itkin-Ansari P

Sat Aug 01 00:00:00 UTC 2020

APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin.

Cell reports

Uzureau S,Lecordier L,Uzureau P,Hennig D,Graversen JH,Homblé F,Mfutu PE,Oliveira Arcolino F,Ramos AR,La Rovere RM,Luyten T,Vermeersch M,Tebabi P,Dieu M,Cuypers B,Deborggraeve S,Rabant M,Legendre C,Moestrup SK,Levtchenko E,Bultynck G,Erneux C,Pérez-Morga D,Pays E

Tue Mar 17 00:00:00 UTC 2020

A novel isoform of myosin 18A (Myo18Aγ) is an essential sarcomeric protein in mouse heart.

The Journal of biological chemistry

Horsthemke M,Nutter LMJ,Bachg AC,Skryabin BV,Honnert U,Zobel T,Bogdan S,Stoll M,Seidl MD,Müller FU,Ravens U,Unger A,Linke WA,van Gorp PRR,de Vries AAF,Bähler M,Hanley PJ

Fri May 03 00:00:00 UTC 2019

A Portrait of the Human Organelle Proteome In Space and Time during Cytomegalovirus Infection.

Cell systems

Jean Beltran PM,Mathias RA,Cristea IM

Wed Oct 26 00:00:00 UTC 2016

A Portrait of the Human Organelle Proteome In Space and Time during Cytomegalovirus Infection.

Cell systems

Jean Beltran PM,Mathias RA,Cristea IM

Wed Oct 26 00:00:00 UTC 2016

A Portrait of the Human Organelle Proteome In Space and Time during Cytomegalovirus Infection.

Cell systems

Jean Beltran PM,Mathias RA,Cristea IM

Wed Oct 26 00:00:00 UTC 2016

A Portrait of the Human Organelle Proteome In Space and Time during Cytomegalovirus Infection.

Cell systems

Jean Beltran PM,Mathias RA,Cristea IM

Wed Oct 26 00:00:00 UTC 2016

Identification of CD245 as myosin 18A, a receptor for surfactant A: A novel pathway for activating human NK lymphocytes.

Oncoimmunology

De Masson A,Giustiniani J,Marie-Cardine A,Bouaziz JD,Dulphy N,Gossot D,Validire P,Tazi A,Garbar C,Bagot M,Merrouche Y,Bensussan A

Sun May 01 00:00:00 UTC 2016

Identification of CD245 as myosin 18A, a receptor for surfactant A: A novel pathway for activating human NK lymphocytes.

Oncoimmunology

De Masson A,Giustiniani J,Marie-Cardine A,Bouaziz JD,Dulphy N,Gossot D,Validire P,Tazi A,Garbar C,Bagot M,Merrouche Y,Bensussan A

Sun May 01 00:00:00 UTC 2016

GM-CSF modulates pulmonary resistance to influenza A infection.

Antiviral research

Sever-Chroneos Z,Murthy A,Davis J,Florence JM,Kurdowska A,Krupa A,Tichelaar JW,White MR,Hartshorn KL,Kobzik L,Whitsett JA,Chroneos ZC

Tue Nov 01 00:00:00 UTC 2011

GM-CSF modulates pulmonary resistance to influenza A infection.

Antiviral research

Sever-Chroneos Z,Murthy A,Davis J,Florence JM,Kurdowska A,Krupa A,Tichelaar JW,White MR,Hartshorn KL,Kobzik L,Whitsett JA,Chroneos ZC

Tue Nov 01 00:00:00 UTC 2011

Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A.

The Journal of biological chemistry

Sever-Chroneos Z,Krupa A,Davis J,Hasan M,Yang CH,Szeliga J,Herrmann M,Hussain M,Geisbrecht BV,Kobzik L,Chroneos ZC

Fri Feb 11 00:00:00 UTC 2011

The Journal of biological chemistry

Sever-Chroneos Z,Krupa A,Davis J,Hasan M,Yang CH,Szeliga J,Herrmann M,Hussain M,Geisbrecht BV,Kobzik L,Chroneos ZC

Fri Feb 11 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: MAJN; Molecule associated with JAK3 N-terminus; myosin 18A; Myosin containing a PDZ domain; myosin containing PDZ domain; myosin XVIIIb; myosin-XVIIIa; SP-A receptor subunit SP-R210 alphaS; SP-R210; Surfactant protein receptor SP-R210; Unconventional myosin-XVIIIa

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Gene Aliases: CD245; KIAA0216; MAJN; MYO18A; MyoPDZ; MYSPDZ; SPR210; TIAF1

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UniProt ID: (Human) Q92614, (Mouse) Q9JMH9

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Entrez Gene ID: (Human) 399687, (Rat) 360570, (Mouse) 360013

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Function(s)

DNA binding protein binding ATP binding ATPase activity ADP binding poly(A) RNA binding actin filament binding motor activity nucleotide binding

Process(es)

DNA metabolic process Golgi organization cell migration actomyosin structure organization negative regulation of apoptotic process Golgi vesicle budding positive regulation of protein secretion Golgi ribbon formation asymmetric Golgi ribbon formation metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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MYO18A Polyclonal Antibody

MYO18A Antibody (14611-1-AP) in WB

Product Details

14611-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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