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Invitrogen
MYO5A Polyclonal Antibody
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FIGURE: 1 / 2
MYO5A Antibody (PA5-19366) in ICC/IF
Immunocytochemistry analysis of MYO5A using MYO5A Polyclonal Antibody (Product # PA5-19366) (1 µg/mL) in Mouse Skeletal Muscle (first panel, and in green in third panel). Alpha-bungaratoxin staining in middle panel and in red in third panel. Detected by Fluorescence. Data kindly provided by Dr. Rüdiger Rudolf, Karlsruhe, Germany.
Product Details
PA5-19366
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (ETKQLELDLN) corresponding to the internal amino acids of MYO5A (aa 1063-1072).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10983601
Product Specific Information
This antibody is predicted to react with bovine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
This gene is one of three myosin V heavy-chain genes, belonging to the myosin gene superfamily. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: dilute lethal-20J protein; Dilute myosin heavy chain, non-muscle; flailer; Myosin heavy chain 12; myosin V; myosin VA (heavy chain 12, myoxin); myosin, heavy polypeptide kinase; Myosin-12; myosin-Va; Myoxin; OTTMUSP00000017756; OTTMUSP00000019176; OTTMUSP00000046608; Unconventional myosin-Va
Gene Aliases: 9630007J19Rik; AI413174; AI661011; d; d-120J; Dbv; Dilute; flail; flr; GS1; MVa; MYH12; MYO5; MYO5A; MyoVA; MYR12; Sev-1
UniProt ID: (Human) Q9Y4I1, (Mouse) Q99104
Entrez Gene ID: (Human) 4644, (Mouse) 17918
microfilament motor activity
actin binding
calcium ion binding
calmodulin binding
ATP binding
Rab GTPase binding
poly(A) RNA binding
SNARE binding
nucleotide binding
motor activity
protein binding
syntaxin-1 binding
ATP-dependent protein binding
protein heterodimerization activity
protein dimerization activity
calcium-dependent protein binding
melanin metabolic process
transport
exocytosis
post-Golgi vesicle-mediated transport
chemical synaptic transmission
visual perception
metabolic process
protein transport
vesicle-mediated transport
regulation of exocytosis
actin filament-based movement
vesicle transport along actin filament
insulin secretion
melanocyte differentiation
regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
locomotion involved in locomotory behavior
secretory granule localization
melanosome localization
melanosome transport
cellular response to insulin stimulus
melanin biosynthetic process
odontogenesis
myelination
anagen
long-chain fatty acid biosynthetic process
pigmentation
developmental pigmentation
synapse organization
neuromuscular process controlling balance
endoplasmic reticulum localization
protein localization to plasma membrane
regulation of Golgi organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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